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Leber's Hereditary Optic Neuropathy Arising From the Synergy Between ND1 3635G>A Mutation and Mitochondrial YARS2 Mutations

PURPOSE: To investigate the mechanism underlying the synergic interaction between Leber's hereditary optic neuropathy (LHON)-associated ND1 and mitochondrial tyrosyl-tRNA synthetase (YARS2) mutations. METHODS: Molecular dynamics simulation and differential scanning fluorimetry were used to eval...

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Detalles Bibliográficos
Autores principales:	Jin, Xiaofen, Zhang, Juanjuan, Yi, Qiuzi, Meng, Feilong, Yu, Jialing, Ji, Yanchun, Mo, Jun Q., Tong, Yi, Jiang, Pingping, Guan, Min-Xin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2021
Materias:	Biochemistry and Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8237128/ https://www.ncbi.nlm.nih.gov/pubmed/34156427 http://dx.doi.org/10.1167/iovs.62.7.22

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