Targeting human plasmacytoid dendritic cells through BDCA2 prevents skin inflammation and fibrosis in a novel xenotransplant mouse model of scleroderma

OBJECTIVES: Plasmacytoid dendritic cells (pDC) have been implicated in the pathogenesis of autoimmune diseases, such as scleroderma (SSc). However, this has been derived from indirect evidence using ex vivo human samples or mouse pDC in vivo. We have developed human-specific pDC models to directly i...

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Detalles Bibliográficos
Autores principales: Ross, Rebecca L, Corinaldesi, Clarissa, Migneco, Gemma, Carr, Ian M, Antanaviciute, Agne, Wasson, Christopher W, Carriero, Antonio, Distler, Jörg H W, Holmes, Steve, El-Sherbiny, Yasser M, McKimmie, Clive S, Del Galdo, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Systemic Sclerosis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8237203/
https://www.ncbi.nlm.nih.gov/pubmed/33542104
http://dx.doi.org/10.1136/annrheumdis-2020-218439

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