Cargando…

The Role of Notch3 Signaling in Cancer Stemness and Chemoresistance: Molecular Mechanisms and Targeting Strategies

Aberrant Notch signaling profoundly affects cancer progression. Especially the Notch3 receptor was found to be dysregulated in cancer, where its expression is correlated with worse clinicopathological features and poor prognosis. The activation of Notch3 signaling is closely related to the activatio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xiu, Mengxi, Wang, Yongbo, Li, Baoli, Wang, Xifeng, Xiao, Fan, Chen, Shoulin, Zhang, Lieliang, Zhou, Bin, Hua, Fuzhou
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8237348/ https://www.ncbi.nlm.nih.gov/pubmed/34195229 http://dx.doi.org/10.3389/fmolb.2021.694141

Ejemplares similares

The Role of Notch Signaling Pathway in Non-Alcoholic Fatty Liver Disease
por: Xu, Hao, et al.
Publicado: (2021)

Overcoming Chemoresistance via Extracellular Vesicle Inhibition
por: Hayatudin, Raeesah, et al.
Publicado: (2021)

Molecular Chaperone BRICHOS Inhibits CADASIL-Mutated NOTCH3 Aggregation In Vitro
por: Oliveira, Daniel V., et al.
Publicado: (2022)

Extracellular Vesicle-Mediated Chemoresistance in Oral Squamous Cell Carcinoma
por: Law, Zhu-Jun, et al.
Publicado: (2021)

Overcome Chemoresistance: Biophysical and Structural Analysis of Synthetic FHIT-Derived Peptides
por: Scala, Maria Carmina, et al.
Publicado: (2021)

TRPV4 is a Prognostic Biomarker that Correlates with the Immunosuppressive Microenvironment and Chemoresistance of Anti-Cancer Drugs
por: Wang, Kai, et al.
Publicado: (2021)

Corrigendum: Overcome Chemoresistance: Biophysical and Structural Analysis of Synthetic FHIT-Derived Peptides
por: Scala, Maria Carmina, et al.
Publicado: (2022)

Nrf2 Modulates the Hybrid Epithelial/Mesenchymal Phenotype and Notch Signaling During Collective Cancer Migration
por: Vilchez Mercedes, Samuel A., et al.
Publicado: (2022)

Regulation of myeloid and lymphoid cell development by O-glycans on Notch
por: Stanley, Pamela, et al.
Publicado: (2022)

Dual roles of interleukin-33 in cognitive function by regulating central nervous system inflammation
por: Rao, Xiuqin, et al.
Publicado: (2022)

Molecular Strategies to Target Protein Aggregation in Huntington’s Disease
por: Jarosińska, Olga D., et al.
Publicado: (2021)

Mutations in NOTCH3 Gene may Promote the Clinical Presentation of Spinocerebellar Ataxia Type 37 Caused by Mutations in DAB1 Gene
por: Wang, Zhao-Wei, et al.
Publicado: (2021)

Delivery of Anti-miRNA-221 for Colorectal Carcinoma Therapy Using Modified Cord Blood Mesenchymal Stem Cells-Derived Exosomes
por: Han, Siqi, et al.
Publicado: (2021)

Lung Adenocarcinoma Cells Promote Self-Migration and Self-Invasion by Activating Neutrophils to Upregulate Notch3 Expression of Cancer Cells
por: Peng, Weidong, et al.
Publicado: (2022)

Molecular Pathogenesis, Immunopathogenesis and Novel Therapeutic Strategy Against COVID-19
por: Chatterjee, Swapan K., et al.
Publicado: (2020)

Cross-regulation between SOX9 and the canonical Wnt signalling pathway in stem cells
por: Wang, Jiajia, et al.
Publicado: (2023)

From Prokaryotes to Eukaryotes: Insights Into the Molecular Structure of Glycogen Particles
por: Liu, Qing-Hua, et al.
Publicado: (2021)

Proteomic Study of Aqueous Humor and Its Application in the Treatment of Neovascular Glaucoma
por: Yu, Mengxi, et al.
Publicado: (2020)

Lipid metabolism and storage in neuroglia: role in brain development and neurodegenerative diseases
por: Yang, Danying, et al.
Publicado: (2022)

ZEB1 Mediates Bone Marrow Mesenchymal Stem Cell Osteogenic Differentiation Partly via Wnt/β-Catenin Signaling
por: Xu, Cuidi, et al.
Publicado: (2021)

Lateral Mesoderm-Derived Mesenchymal Stem Cells With Robust Osteochondrogenic Potential and Hematopoiesis-Supporting Ability
por: Wei, Yili, et al.
Publicado: (2022)

Graphene Oxide Nanoparticle–Loaded Ginsenoside Rg3 Improves Photodynamic Therapy in Inhibiting Malignant Progression and Stemness of Osteosarcoma
por: Lu, Shou-Liang, et al.
Publicado: (2021)

Pan-Cancer Prognostic, Immunity, Stemness, and Anticancer Drug Sensitivity Characterization of N6-Methyladenosine RNA Modification Regulators in Human Cancers
por: Li, Rui, et al.
Publicado: (2021)

Predicting Metabolite-Disease Associations Based on Spy Strategy and ABC Algorithm
por: Lei, Xiujuan, et al.
Publicado: (2020)

Molecular and Clinical Characteristics of Primary Pulmonary Lymphoepithelioma-Like Carcinoma
por: Fan, Ying, et al.
Publicado: (2021)

Temporal Control of the WNT Signaling Pathway During Cardiac Differentiation Impacts Upon the Maturation State of Human Pluripotent Stem Cell Derived Cardiomyocytes
por: Tsoi, Chantelle, et al.
Publicado: (2022)

mRNA Translation Is Dynamically Regulated to Instruct Stem Cell Fate
por: Wang, Ruoxu, et al.
Publicado: (2022)

Structure and Molecular Mechanism of ER Stress Signaling by the Unfolded Protein Response Signal Activator IRE1
por: Adams, Christopher J., et al.
Publicado: (2019)

Editorial: Novel Molecular Mechanisms and Innovative Therapeutic Approaches for Age-Associated Diseases
por: Sun, Leming, et al.
Publicado: (2022)

The Integrative Analysis Identifies Three Cancer Subtypes and Stemness Features in Cutaneous Melanoma
por: Wang, Xiaoran, et al.
Publicado: (2021)

Molecular Dissection of Pro-Fibrotic IL11 Signaling in Cardiac and Pulmonary Fibroblasts
por: Widjaja, Anissa A., et al.
Publicado: (2021)

Identification of the Core MicroRNAs and Potential Molecular Mechanismsin Sarcoidosis Using Bioinformatics Analysis
por: Cao, Yuan, et al.
Publicado: (2021)

Understanding Thermostability Factors of Barley Limit Dextrinase by Molecular Dynamics Simulations
por: Du, Juan, et al.
Publicado: (2020)

On the energy components governing molecular recognition in the framework of continuum approaches
por: Li, Lin, et al.
Publicado: (2015)

TRP Channels as Molecular Targets to Relieve Endocrine-Related Diseases
por: Liu, Yusheng, et al.
Publicado: (2022)

Molecular Basis of S100A1 Activation and Target Regulation Within Physiological Cytosolic Ca(2+) Levels
por: Sun, Bin, et al.
Publicado: (2020)

A Species-Specific Strategy for the Identification of Hemocoagulase Agkistrodon halys pallas Based on LC-MS/MS-MRM
por: Xian, Ruiqing, et al.
Publicado: (2022)

Characteristic Analysis of Featured Genes Associated With Stemness Indices in Colorectal Cancer
por: Lu, Yongqu, et al.
Publicado: (2020)

Validated Impacts of N6-Methyladenosine Methylated mRNAs on Apoptosis and Angiogenesis in Myocardial Infarction Based on MeRIP-Seq Analysis
por: Zhang, Yingjie, et al.
Publicado: (2022)

Unveiling the molecular structure and role of RBBP4/7: implications for epigenetic regulation and cancer research
por: Cai, Lize, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_rqts69o61kg4v6lqsohicv0h0r