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Smek1 deficiency exacerbates experimental autoimmune encephalomyelitis by activating proinflammatory microglia and suppressing the IDO1-AhR pathway

BACKGROUND: Experimental autoimmune encephalomyelitis (EAE) is an animal disease model of multiple sclerosis (MS) that involves the immune system and central nervous system (CNS). However, it is unclear how genetic predispositions promote neuroinflammation in MS and EAE. Here, we investigated how pa...

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Detalles Bibliográficos
Autores principales:	Duan, Ruo-Nan, Yang, Chun-Lin, Du, Tong, Liu, Ai, Wang, An-Ran, Sun, Wen-Jie, Li, Xi, Li, Jiang-Xia, Yan, Chuan-Zhu, Liu, Qi-Ji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8237434/ https://www.ncbi.nlm.nih.gov/pubmed/34183017 http://dx.doi.org/10.1186/s12974-021-02193-0

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