Cargando…

Potency boost of a Mycobacterium tuberculosis dihydrofolate reductase inhibitor by multienzyme F(420)H(2)-dependent reduction

Triaza-coumarin (TA-C) is a Mycobacterium tuberculosis (Mtb) dihydrofolate reductase (DHFR) inhibitor with an IC(50) (half maximal inhibitory concentration) of ∼1 µM against the enzyme. Despite this moderate target inhibition, TA-C shows exquisite antimycobacterial activity (MIC(50), concentration i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Aragaw, Wassihun Wedajo, Lee, Brendon M., Yang, Xuan, Zimmerman, Matthew D., Gengenbacher, Martin, Dartois, Véronique, Chui, Wai-Keung, Jackson, Colin J., Dick, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2021
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8237569/ https://www.ncbi.nlm.nih.gov/pubmed/34161270 http://dx.doi.org/10.1073/pnas.2025172118

Ejemplares similares

Cyclohexyl-griselimycin Is Active against Mycobacterium abscessus in Mice
por: Aragaw, Wassihun Wedajo, et al.
Publicado: (2022)

Characterization of In Vitro Resistance to Linezolid in Mycobacterium abscessus
por: Negatu, Dereje A., et al.
Publicado: (2023)

Piperidine-4-Carboxamides Target DNA Gyrase in Mycobacterium abscessus
por: Negatu, Dereje Abate, et al.
Publicado: (2021)

Side-by-Side Profiling of Oxazolidinones to Estimate the Therapeutic Window against Mycobacterial Infections
por: Negatu, Dereje A., et al.
Publicado: (2023)

A Mycobacterium tuberculosis NBTI DNA Gyrase Inhibitor Is Active against Mycobacterium abscessus
por: Ganapathy, Uday S., et al.
Publicado: (2021)

In Vitro Resistance against DNA Gyrase Inhibitor SPR719 in Mycobacterium avium and Mycobacterium abscessus
por: Aragaw, Wassihun Wedajo, et al.
Publicado: (2022)

Tales of Dihydrofolate Binding to R67 Dihydrofolate Reductase
por: Duff, Michael R., et al.
Publicado: (2015)

Mycobacterium tuberculosis DprE1 Inhibitor OPC-167832 Is Active against Mycobacterium abscessus In Vitro
por: Sarathy, Jickky Palmae, et al.
Publicado: (2022)

Adaptations for Pressure and Temperature in Dihydrofolate Reductases
por: Penhallurick, Ryan W., et al.
Publicado: (2021)

para-Aminosalicylic acid is a prodrug targeting dihydrofolate reductase in Mycobacterium tuberculosis.
por: Zheng, Jun, et al.
Publicado: (2013)

TBAJ-876, a 3,5-Dialkoxypyridine Analogue of Bedaquiline, Is Active against Mycobacterium abscessus
por: Sarathy, Jickky Palmae, et al.
Publicado: (2020)

Minimization of dynamic effects in the evolution of dihydrofolate reductase
por: Ruiz-Pernía, J. Javier, et al.
Publicado: (2016)

Binding of Natural and Synthetic Polyphenols to Human Dihydrofolate Reductase
por: Sánchez-del-Campo, Luís, et al.
Publicado: (2009)

The Role of Large-Scale Motions in Catalysis by Dihydrofolate Reductase
por: Loveridge, E. Joel, et al.
Publicado: (2011)

Side Chain Conformational Averaging in Human Dihydrofolate Reductase
por: Tuttle, Lisa M., et al.
Publicado: (2014)

Divergent evolution of protein conformational dynamics in dihydrofolate reductase
por: Bhabha, Gira, et al.
Publicado: (2013)

Evolution Alters the Enzymatic Reaction Coordinate of Dihydrofolate Reductase
por: Masterson, Jean E., et al.
Publicado: (2014)

Different Dynamical Effects in Mesophilic and Hyperthermophilic Dihydrofolate Reductases
por: Luk, Louis Y. P., et al.
Publicado: (2014)

Rifabutin Is Active against Mycobacterium abscessus in Mice
por: Dick, Thomas, et al.
Publicado: (2020)

Combined gene deletion of dihydrofolate reductase-thymidylate synthase and pteridine reductase in Leishmania infantum
por: Bhattacharya, Arijit, et al.
Publicado: (2021)

Dihydrofolate Reductase Gene Variations in Susceptibility to Disease and Treatment Outcomes
por: Askari, Bahram S., et al.
Publicado: (2010)

Dihydrofolate reductase as a model for studies of enzyme dynamics and catalysis
por: Kohen, Amnon
Publicado: (2015)

A calibration curve for immobilized dihydrofolate reductase activity assay
por: Singh, Priyanka, et al.
Publicado: (2015)

Lausannevirus Encodes a Functional Dihydrofolate Reductase Susceptible to Proguanil
por: Mueller, L., et al.
Publicado: (2017)

Hypermethylation of dihydrofolate reductase promoter increases the risk of hypertension in Chinese
por: Xu, Guodong, et al.
Publicado: (2020)

Metformin sensitises hepatocarcinoma cells to methotrexate by targeting dihydrofolate reductase
por: Wang, Yinghui, et al.
Publicado: (2021)

Computational Development of Inhibitors of Plasmid-Borne Bacterial Dihydrofolate Reductase
por: Silva, Pedro J.
Publicado: (2022)

Indole Propionic Acid, an Unusual Antibiotic Produced by the Gut Microbiota, With Anti-inflammatory and Antioxidant Properties
por: Negatu, Dereje Abate, et al.
Publicado: (2020)

Gut Microbiota Metabolite Indole Propionic Acid Targets Tryptophan Biosynthesis in Mycobacterium tuberculosis
por: Negatu, Dereje Abate, et al.
Publicado: (2019)

Nitrite reductase activity in F(420)-dependent sulphite reductase (Fsr) from Methanocaldococcus jannaschii
por: Heryakusuma, Christian, et al.
Publicado: (2023)

CRISPRi chemical genetics and comparative genomics identify genes mediating drug potency in Mycobacterium tuberculosis
por: Li, Shuqi, et al.
Publicado: (2022)

Development and validation of a cytochrome c-coupled assay for pteridine reductase 1 and dihydrofolate reductase
por: Shanks, Emma J., et al.
Publicado: (2010)

Evidence of Pyrimethamine and Cycloguanil Analogues as Dual Inhibitors of Trypanosoma brucei Pteridine Reductase and Dihydrofolate Reductase
por: Tassone, Giusy, et al.
Publicado: (2021)

Multiple origins of resistance-conferring mutations in Plasmodium vivax dihydrofolate reductase
por: Hawkins, Vivian N, et al.
Publicado: (2008)

Dihydrofolate Reductase I164L Mutation in Plasmodium falciparum, Madagascar
por: Ménard, Didier, et al.
Publicado: (2008)

Computational analysis of binding between malarial dihydrofolate reductases and anti-folates
por: Choowongkomon, Kiattawee, et al.
Publicado: (2010)

Thermal Adaptation of Dihydrofolate Reductase from the Moderate Thermophile Geobacillus stearothermophilus
por: Guo, Jiannan, et al.
Publicado: (2014)

Optimized peptide based inhibitors targeting the dihydrofolate reductase pathway in cancer
por: Singh, Amrinder, et al.
Publicado: (2018)

Molecular Docking Analysis of Pyrimethamine Derivatives with Plasmodium falciparum Dihydrofolate Reductase
por: Singh, Indra Vikram, et al.
Publicado: (2018)

Molecular Characteristics and Serodiagnostic Potential of Dihydrofolate Reductase from Echinococcus granulosus
por: Song, Xingju, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_dhg4ancmf8he2nch0jnq6tieam