Cargando…

Helicobacter pylori’s historical journey through Siberia and the Americas

The gastric bacterium Helicobacter pylori shares a coevolutionary history with humans that predates the out-of-Africa diaspora, and the geographical specificities of H. pylori populations reflect multiple well-known human migrations. We extensively sampled H. pylori from 16 ethnically diverse human...

Descripción completa

Detalles Bibliográficos
Autores principales: Moodley, Yoshan, Brunelli, Andrea, Ghirotto, Silvia, Klyubin, Andrey, Maady, Ayas S., Tyne, William, Muñoz-Ramirez, Zilia Y., Zhou, Zhemin, Manica, Andrea, Linz, Bodo, Achtman, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8237685/
https://www.ncbi.nlm.nih.gov/pubmed/34161258
http://dx.doi.org/10.1073/pnas.2015523118
_version_ 1783714768052289536
author Moodley, Yoshan
Brunelli, Andrea
Ghirotto, Silvia
Klyubin, Andrey
Maady, Ayas S.
Tyne, William
Muñoz-Ramirez, Zilia Y.
Zhou, Zhemin
Manica, Andrea
Linz, Bodo
Achtman, Mark
author_facet Moodley, Yoshan
Brunelli, Andrea
Ghirotto, Silvia
Klyubin, Andrey
Maady, Ayas S.
Tyne, William
Muñoz-Ramirez, Zilia Y.
Zhou, Zhemin
Manica, Andrea
Linz, Bodo
Achtman, Mark
author_sort Moodley, Yoshan
collection PubMed
description The gastric bacterium Helicobacter pylori shares a coevolutionary history with humans that predates the out-of-Africa diaspora, and the geographical specificities of H. pylori populations reflect multiple well-known human migrations. We extensively sampled H. pylori from 16 ethnically diverse human populations across Siberia to help resolve whether ancient northern Eurasian populations persisted at high latitudes through the last glacial maximum and the relationships between present-day Siberians and Native Americans. A total of 556 strains were cultivated and genotyped by multilocus sequence typing, and 54 representative draft genomes were sequenced. The genetic diversity across Eurasia and the Americas was structured into three populations: hpAsia2, hpEastAsia, and hpNorthAsia. hpNorthAsia is closely related to the subpopulation hspIndigenousAmericas from Native Americans. Siberian bacteria were structured into five other subpopulations, two of which evolved through a divergence from hpAsia2 and hpNorthAsia, while three originated though Holocene admixture. The presence of both anciently diverged and recently admixed strains across Siberia support both Pleistocene persistence and Holocene recolonization. We also show that hspIndigenousAmericas is endemic in human populations across northern Eurasia. The evolutionary history of hspIndigenousAmericas was reconstructed using approximate Bayesian computation, which showed that it colonized the New World in a single migration event associated with a severe demographic bottleneck followed by low levels of recent admixture across the Bering Strait.
format Online
Article
Text
id pubmed-8237685
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher National Academy of Sciences
record_format MEDLINE/PubMed
spelling pubmed-82376852021-07-03 Helicobacter pylori’s historical journey through Siberia and the Americas Moodley, Yoshan Brunelli, Andrea Ghirotto, Silvia Klyubin, Andrey Maady, Ayas S. Tyne, William Muñoz-Ramirez, Zilia Y. Zhou, Zhemin Manica, Andrea Linz, Bodo Achtman, Mark Proc Natl Acad Sci U S A Biological Sciences The gastric bacterium Helicobacter pylori shares a coevolutionary history with humans that predates the out-of-Africa diaspora, and the geographical specificities of H. pylori populations reflect multiple well-known human migrations. We extensively sampled H. pylori from 16 ethnically diverse human populations across Siberia to help resolve whether ancient northern Eurasian populations persisted at high latitudes through the last glacial maximum and the relationships between present-day Siberians and Native Americans. A total of 556 strains were cultivated and genotyped by multilocus sequence typing, and 54 representative draft genomes were sequenced. The genetic diversity across Eurasia and the Americas was structured into three populations: hpAsia2, hpEastAsia, and hpNorthAsia. hpNorthAsia is closely related to the subpopulation hspIndigenousAmericas from Native Americans. Siberian bacteria were structured into five other subpopulations, two of which evolved through a divergence from hpAsia2 and hpNorthAsia, while three originated though Holocene admixture. The presence of both anciently diverged and recently admixed strains across Siberia support both Pleistocene persistence and Holocene recolonization. We also show that hspIndigenousAmericas is endemic in human populations across northern Eurasia. The evolutionary history of hspIndigenousAmericas was reconstructed using approximate Bayesian computation, which showed that it colonized the New World in a single migration event associated with a severe demographic bottleneck followed by low levels of recent admixture across the Bering Strait. National Academy of Sciences 2021-06-22 2021-06-14 /pmc/articles/PMC8237685/ /pubmed/34161258 http://dx.doi.org/10.1073/pnas.2015523118 Text en Copyright © 2021 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Biological Sciences
Moodley, Yoshan
Brunelli, Andrea
Ghirotto, Silvia
Klyubin, Andrey
Maady, Ayas S.
Tyne, William
Muñoz-Ramirez, Zilia Y.
Zhou, Zhemin
Manica, Andrea
Linz, Bodo
Achtman, Mark
Helicobacter pylori’s historical journey through Siberia and the Americas
title Helicobacter pylori’s historical journey through Siberia and the Americas
title_full Helicobacter pylori’s historical journey through Siberia and the Americas
title_fullStr Helicobacter pylori’s historical journey through Siberia and the Americas
title_full_unstemmed Helicobacter pylori’s historical journey through Siberia and the Americas
title_short Helicobacter pylori’s historical journey through Siberia and the Americas
title_sort helicobacter pylori’s historical journey through siberia and the americas
topic Biological Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8237685/
https://www.ncbi.nlm.nih.gov/pubmed/34161258
http://dx.doi.org/10.1073/pnas.2015523118
work_keys_str_mv AT moodleyyoshan helicobacterpylorishistoricaljourneythroughsiberiaandtheamericas
AT brunelliandrea helicobacterpylorishistoricaljourneythroughsiberiaandtheamericas
AT ghirottosilvia helicobacterpylorishistoricaljourneythroughsiberiaandtheamericas
AT klyubinandrey helicobacterpylorishistoricaljourneythroughsiberiaandtheamericas
AT maadyayass helicobacterpylorishistoricaljourneythroughsiberiaandtheamericas
AT tynewilliam helicobacterpylorishistoricaljourneythroughsiberiaandtheamericas
AT munozramirezziliay helicobacterpylorishistoricaljourneythroughsiberiaandtheamericas
AT zhouzhemin helicobacterpylorishistoricaljourneythroughsiberiaandtheamericas
AT manicaandrea helicobacterpylorishistoricaljourneythroughsiberiaandtheamericas
AT linzbodo helicobacterpylorishistoricaljourneythroughsiberiaandtheamericas
AT achtmanmark helicobacterpylorishistoricaljourneythroughsiberiaandtheamericas