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Comparison of Oxidant Stress Levels among Healthy, Chronic Periodontitis, and Ischemic Heart Disease Subjects with Presence or Absence of Chronic Periodontitis

OBJECTIVE: To investigate the total oxidant levels in healthy, chronic periodontitis (CP), and ischemic heart disease (IHD) and to check for any correlation among them. MATERIALS AND METHODS: A sample of 80 were split into four groups of healthy subjects (Group I), CP subjects (Group II), IHD subjec...

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Autores principales: Pampani, Priyanka, Shenoy, Santhosh, Punj, Anahita, Kamath, Vinayak B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8237816/
https://www.ncbi.nlm.nih.gov/pubmed/34220156
http://dx.doi.org/10.4103/ccd.ccd_192_20
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author Pampani, Priyanka
Shenoy, Santhosh
Punj, Anahita
Kamath, Vinayak B
author_facet Pampani, Priyanka
Shenoy, Santhosh
Punj, Anahita
Kamath, Vinayak B
author_sort Pampani, Priyanka
collection PubMed
description OBJECTIVE: To investigate the total oxidant levels in healthy, chronic periodontitis (CP), and ischemic heart disease (IHD) and to check for any correlation among them. MATERIALS AND METHODS: A sample of 80 were split into four groups of healthy subjects (Group I), CP subjects (Group II), IHD subjects (Group III), and IHD subjects having periodontitis (Group IV). The serum and saliva samples collected were analyzed for levels of hydrogen peroxide (H(2)O(2)), hydroxyl radical (OH(-)), nitric oxide (NO), and superoxide radical (O(2)(-)). RESULTS: There were significant (P < 0.05) variances in the mean serum and salivary levels of hydrogen peroxide, hydroxyl radical, NO, and superoxide within the 4 groups. Oxidant levels of both serum and saliva were lower in disease groups of Group II, III, and IV as compared to healthy controls, with different patterns. CONCLUSION: The oxidant levels (H(2)O(2), OH(-), NO, and O(2)(-)) are significantly hampered in periodontitis and IHD subjects as compared to healthy subjects. The oxidants, whether serum or salivary, did not always show the proportional change as a result of change in oxidant stress due to disease as positive correlation was observed only in the serum H(2)O(2) and salivary NO radical levels and between serum superoxide dismutase radical and salivary H(2)O(2) in Group I. In Group III, there was a positive correlation between serum NO radical and salivary H(2)O(2).
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spelling pubmed-82378162021-07-02 Comparison of Oxidant Stress Levels among Healthy, Chronic Periodontitis, and Ischemic Heart Disease Subjects with Presence or Absence of Chronic Periodontitis Pampani, Priyanka Shenoy, Santhosh Punj, Anahita Kamath, Vinayak B Contemp Clin Dent Original Article OBJECTIVE: To investigate the total oxidant levels in healthy, chronic periodontitis (CP), and ischemic heart disease (IHD) and to check for any correlation among them. MATERIALS AND METHODS: A sample of 80 were split into four groups of healthy subjects (Group I), CP subjects (Group II), IHD subjects (Group III), and IHD subjects having periodontitis (Group IV). The serum and saliva samples collected were analyzed for levels of hydrogen peroxide (H(2)O(2)), hydroxyl radical (OH(-)), nitric oxide (NO), and superoxide radical (O(2)(-)). RESULTS: There were significant (P < 0.05) variances in the mean serum and salivary levels of hydrogen peroxide, hydroxyl radical, NO, and superoxide within the 4 groups. Oxidant levels of both serum and saliva were lower in disease groups of Group II, III, and IV as compared to healthy controls, with different patterns. CONCLUSION: The oxidant levels (H(2)O(2), OH(-), NO, and O(2)(-)) are significantly hampered in periodontitis and IHD subjects as compared to healthy subjects. The oxidants, whether serum or salivary, did not always show the proportional change as a result of change in oxidant stress due to disease as positive correlation was observed only in the serum H(2)O(2) and salivary NO radical levels and between serum superoxide dismutase radical and salivary H(2)O(2) in Group I. In Group III, there was a positive correlation between serum NO radical and salivary H(2)O(2). Wolters Kluwer - Medknow 2021 2021-06-14 /pmc/articles/PMC8237816/ /pubmed/34220156 http://dx.doi.org/10.4103/ccd.ccd_192_20 Text en Copyright: © 2021 Contemporary Clinical Dentistry https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Pampani, Priyanka
Shenoy, Santhosh
Punj, Anahita
Kamath, Vinayak B
Comparison of Oxidant Stress Levels among Healthy, Chronic Periodontitis, and Ischemic Heart Disease Subjects with Presence or Absence of Chronic Periodontitis
title Comparison of Oxidant Stress Levels among Healthy, Chronic Periodontitis, and Ischemic Heart Disease Subjects with Presence or Absence of Chronic Periodontitis
title_full Comparison of Oxidant Stress Levels among Healthy, Chronic Periodontitis, and Ischemic Heart Disease Subjects with Presence or Absence of Chronic Periodontitis
title_fullStr Comparison of Oxidant Stress Levels among Healthy, Chronic Periodontitis, and Ischemic Heart Disease Subjects with Presence or Absence of Chronic Periodontitis
title_full_unstemmed Comparison of Oxidant Stress Levels among Healthy, Chronic Periodontitis, and Ischemic Heart Disease Subjects with Presence or Absence of Chronic Periodontitis
title_short Comparison of Oxidant Stress Levels among Healthy, Chronic Periodontitis, and Ischemic Heart Disease Subjects with Presence or Absence of Chronic Periodontitis
title_sort comparison of oxidant stress levels among healthy, chronic periodontitis, and ischemic heart disease subjects with presence or absence of chronic periodontitis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8237816/
https://www.ncbi.nlm.nih.gov/pubmed/34220156
http://dx.doi.org/10.4103/ccd.ccd_192_20
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