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The Mechanism of Stimulating and Mobilizing the Immune System Enhancing the Anti-Tumor Immunity

Cancer immunotherapy is a kind of therapy that can control and eliminate tumors by restarting and maintaining the tumor-immune cycle and restoring the body’s normal anti-tumor immune response. Although immunotherapy has great potential, it is currently only applicable to patients with certain types...

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Detalles Bibliográficos
Autores principales: Wu, Zhengguo, Li, Shang, Zhu, Xiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8237941/
https://www.ncbi.nlm.nih.gov/pubmed/34194437
http://dx.doi.org/10.3389/fimmu.2021.682435
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author Wu, Zhengguo
Li, Shang
Zhu, Xiao
author_facet Wu, Zhengguo
Li, Shang
Zhu, Xiao
author_sort Wu, Zhengguo
collection PubMed
description Cancer immunotherapy is a kind of therapy that can control and eliminate tumors by restarting and maintaining the tumor-immune cycle and restoring the body’s normal anti-tumor immune response. Although immunotherapy has great potential, it is currently only applicable to patients with certain types of tumors, such as melanoma, lung cancer, and cancer with high mutation load and microsatellite instability, and even in these types of tumors, immunotherapy is not effective for all patients. In order to enhance the effectiveness of tumor immunotherapy, this article reviews the research progress of tumor microenvironment immunotherapy, and studies the mechanism of stimulating and mobilizing immune system to enhance anti-tumor immunity. In this review, we focused on immunotherapy against tumor microenvironment (TME) and discussed the important research progress. TME is the environment for the survival and development of tumor cells, which is composed of cell components and non-cell components; immunotherapy for TME by stimulating or mobilizing the immune system of the body, enhancing the anti-tumor immunity. The checkpoint inhibitors can effectively block the inhibitory immunoregulation, indirectly strengthen the anti-tumor immune response and improve the effect of immunotherapy. We also found the checkpoint inhibitors have brought great changes to the treatment model of advanced tumors, but the clinical treatment results show great individual differences. Based on the close attention to the future development trend of immunotherapy, this study summarized the latest progress of immunotherapy and pointed out a new direction. To study the mechanism of stimulating and mobilizing the immune system to enhance anti-tumor immunity can provide new opportunities for cancer treatment, expand the clinical application scope and effective population of cancer immunotherapy, and improve the survival rate of cancer patients.
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spelling pubmed-82379412021-06-29 The Mechanism of Stimulating and Mobilizing the Immune System Enhancing the Anti-Tumor Immunity Wu, Zhengguo Li, Shang Zhu, Xiao Front Immunol Immunology Cancer immunotherapy is a kind of therapy that can control and eliminate tumors by restarting and maintaining the tumor-immune cycle and restoring the body’s normal anti-tumor immune response. Although immunotherapy has great potential, it is currently only applicable to patients with certain types of tumors, such as melanoma, lung cancer, and cancer with high mutation load and microsatellite instability, and even in these types of tumors, immunotherapy is not effective for all patients. In order to enhance the effectiveness of tumor immunotherapy, this article reviews the research progress of tumor microenvironment immunotherapy, and studies the mechanism of stimulating and mobilizing immune system to enhance anti-tumor immunity. In this review, we focused on immunotherapy against tumor microenvironment (TME) and discussed the important research progress. TME is the environment for the survival and development of tumor cells, which is composed of cell components and non-cell components; immunotherapy for TME by stimulating or mobilizing the immune system of the body, enhancing the anti-tumor immunity. The checkpoint inhibitors can effectively block the inhibitory immunoregulation, indirectly strengthen the anti-tumor immune response and improve the effect of immunotherapy. We also found the checkpoint inhibitors have brought great changes to the treatment model of advanced tumors, but the clinical treatment results show great individual differences. Based on the close attention to the future development trend of immunotherapy, this study summarized the latest progress of immunotherapy and pointed out a new direction. To study the mechanism of stimulating and mobilizing the immune system to enhance anti-tumor immunity can provide new opportunities for cancer treatment, expand the clinical application scope and effective population of cancer immunotherapy, and improve the survival rate of cancer patients. Frontiers Media S.A. 2021-06-10 /pmc/articles/PMC8237941/ /pubmed/34194437 http://dx.doi.org/10.3389/fimmu.2021.682435 Text en Copyright © 2021 Wu, Li and Zhu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Wu, Zhengguo
Li, Shang
Zhu, Xiao
The Mechanism of Stimulating and Mobilizing the Immune System Enhancing the Anti-Tumor Immunity
title The Mechanism of Stimulating and Mobilizing the Immune System Enhancing the Anti-Tumor Immunity
title_full The Mechanism of Stimulating and Mobilizing the Immune System Enhancing the Anti-Tumor Immunity
title_fullStr The Mechanism of Stimulating and Mobilizing the Immune System Enhancing the Anti-Tumor Immunity
title_full_unstemmed The Mechanism of Stimulating and Mobilizing the Immune System Enhancing the Anti-Tumor Immunity
title_short The Mechanism of Stimulating and Mobilizing the Immune System Enhancing the Anti-Tumor Immunity
title_sort mechanism of stimulating and mobilizing the immune system enhancing the anti-tumor immunity
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8237941/
https://www.ncbi.nlm.nih.gov/pubmed/34194437
http://dx.doi.org/10.3389/fimmu.2021.682435
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