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Potassium Channel Protein KCNK6 Promotes Breast Cancer Cell Proliferation, Invasion, and Migration

Breast cancer is the most common malignant tumor in women, and its incidence is increasing each year. To effectively treat breast cancer, it is important to identify genes involved in its occurrence and development and to exploit them as potential drug therapy targets. Here, we found that potassium...

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Autores principales: Hou, Xiangchan, Tang, Le, Li, Xiayu, Xiong, Fang, Mo, Yongzhen, Jiang, Xianjie, Deng, Xiangying, Peng, Miao, Wu, Pan, Zhao, Mengyao, Ouyang, Jiawei, Shi, Lei, He, Yi, Yan, Qijia, Zhang, Shanshan, Gong, Zhaojian, Li, Guiyuan, Zeng, Zhaoyang, Wang, Fuyan, Guo, Can, Xiong, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8237943/
https://www.ncbi.nlm.nih.gov/pubmed/34195184
http://dx.doi.org/10.3389/fcell.2021.616784
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author Hou, Xiangchan
Tang, Le
Li, Xiayu
Xiong, Fang
Mo, Yongzhen
Jiang, Xianjie
Deng, Xiangying
Peng, Miao
Wu, Pan
Zhao, Mengyao
Ouyang, Jiawei
Shi, Lei
He, Yi
Yan, Qijia
Zhang, Shanshan
Gong, Zhaojian
Li, Guiyuan
Zeng, Zhaoyang
Wang, Fuyan
Guo, Can
Xiong, Wei
author_facet Hou, Xiangchan
Tang, Le
Li, Xiayu
Xiong, Fang
Mo, Yongzhen
Jiang, Xianjie
Deng, Xiangying
Peng, Miao
Wu, Pan
Zhao, Mengyao
Ouyang, Jiawei
Shi, Lei
He, Yi
Yan, Qijia
Zhang, Shanshan
Gong, Zhaojian
Li, Guiyuan
Zeng, Zhaoyang
Wang, Fuyan
Guo, Can
Xiong, Wei
author_sort Hou, Xiangchan
collection PubMed
description Breast cancer is the most common malignant tumor in women, and its incidence is increasing each year. To effectively treat breast cancer, it is important to identify genes involved in its occurrence and development and to exploit them as potential drug therapy targets. Here, we found that potassium channel subfamily K member 6 (KCNK6) is significantly overexpressed in breast cancer, however, its function in tumors has not been reported. We further verified that KCNK6 expression is upregulated in breast cancer biopsies. Moreover, overexpressed KCNK6 was found to enhance the proliferation, invasion, and migration ability of breast cancer cells. These effects may occur by weakening cell adhesion and reducing cell hardness, thus affecting the malignant phenotype of breast cancer cells. Our study confirmed, for the first time, that increased KCNK6 expression in breast cancer cells may promote their proliferation, invasion, and migration. Moreover, considering that ion channels serve as therapeutic targets for many small molecular drugs in clinical treatment, targeting KCNK6 may represent a novel strategy for breast cancer therapies. Hence, the results of this study provide a theoretical basis for KCNK6 to become a potential molecular target for breast cancer treatment in the future.
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spelling pubmed-82379432021-06-29 Potassium Channel Protein KCNK6 Promotes Breast Cancer Cell Proliferation, Invasion, and Migration Hou, Xiangchan Tang, Le Li, Xiayu Xiong, Fang Mo, Yongzhen Jiang, Xianjie Deng, Xiangying Peng, Miao Wu, Pan Zhao, Mengyao Ouyang, Jiawei Shi, Lei He, Yi Yan, Qijia Zhang, Shanshan Gong, Zhaojian Li, Guiyuan Zeng, Zhaoyang Wang, Fuyan Guo, Can Xiong, Wei Front Cell Dev Biol Cell and Developmental Biology Breast cancer is the most common malignant tumor in women, and its incidence is increasing each year. To effectively treat breast cancer, it is important to identify genes involved in its occurrence and development and to exploit them as potential drug therapy targets. Here, we found that potassium channel subfamily K member 6 (KCNK6) is significantly overexpressed in breast cancer, however, its function in tumors has not been reported. We further verified that KCNK6 expression is upregulated in breast cancer biopsies. Moreover, overexpressed KCNK6 was found to enhance the proliferation, invasion, and migration ability of breast cancer cells. These effects may occur by weakening cell adhesion and reducing cell hardness, thus affecting the malignant phenotype of breast cancer cells. Our study confirmed, for the first time, that increased KCNK6 expression in breast cancer cells may promote their proliferation, invasion, and migration. Moreover, considering that ion channels serve as therapeutic targets for many small molecular drugs in clinical treatment, targeting KCNK6 may represent a novel strategy for breast cancer therapies. Hence, the results of this study provide a theoretical basis for KCNK6 to become a potential molecular target for breast cancer treatment in the future. Frontiers Media S.A. 2021-06-14 /pmc/articles/PMC8237943/ /pubmed/34195184 http://dx.doi.org/10.3389/fcell.2021.616784 Text en Copyright © 2021 Hou, Tang, Li, Xiong, Mo, Jiang, Deng, Peng, Wu, Zhao, Ouyang, Shi, He, Yan, Zhang, Gong, Li, Zeng, Wang, Guo and Xiong. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Hou, Xiangchan
Tang, Le
Li, Xiayu
Xiong, Fang
Mo, Yongzhen
Jiang, Xianjie
Deng, Xiangying
Peng, Miao
Wu, Pan
Zhao, Mengyao
Ouyang, Jiawei
Shi, Lei
He, Yi
Yan, Qijia
Zhang, Shanshan
Gong, Zhaojian
Li, Guiyuan
Zeng, Zhaoyang
Wang, Fuyan
Guo, Can
Xiong, Wei
Potassium Channel Protein KCNK6 Promotes Breast Cancer Cell Proliferation, Invasion, and Migration
title Potassium Channel Protein KCNK6 Promotes Breast Cancer Cell Proliferation, Invasion, and Migration
title_full Potassium Channel Protein KCNK6 Promotes Breast Cancer Cell Proliferation, Invasion, and Migration
title_fullStr Potassium Channel Protein KCNK6 Promotes Breast Cancer Cell Proliferation, Invasion, and Migration
title_full_unstemmed Potassium Channel Protein KCNK6 Promotes Breast Cancer Cell Proliferation, Invasion, and Migration
title_short Potassium Channel Protein KCNK6 Promotes Breast Cancer Cell Proliferation, Invasion, and Migration
title_sort potassium channel protein kcnk6 promotes breast cancer cell proliferation, invasion, and migration
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8237943/
https://www.ncbi.nlm.nih.gov/pubmed/34195184
http://dx.doi.org/10.3389/fcell.2021.616784
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