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Potassium Channel Protein KCNK6 Promotes Breast Cancer Cell Proliferation, Invasion, and Migration
Breast cancer is the most common malignant tumor in women, and its incidence is increasing each year. To effectively treat breast cancer, it is important to identify genes involved in its occurrence and development and to exploit them as potential drug therapy targets. Here, we found that potassium...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8237943/ https://www.ncbi.nlm.nih.gov/pubmed/34195184 http://dx.doi.org/10.3389/fcell.2021.616784 |
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author | Hou, Xiangchan Tang, Le Li, Xiayu Xiong, Fang Mo, Yongzhen Jiang, Xianjie Deng, Xiangying Peng, Miao Wu, Pan Zhao, Mengyao Ouyang, Jiawei Shi, Lei He, Yi Yan, Qijia Zhang, Shanshan Gong, Zhaojian Li, Guiyuan Zeng, Zhaoyang Wang, Fuyan Guo, Can Xiong, Wei |
author_facet | Hou, Xiangchan Tang, Le Li, Xiayu Xiong, Fang Mo, Yongzhen Jiang, Xianjie Deng, Xiangying Peng, Miao Wu, Pan Zhao, Mengyao Ouyang, Jiawei Shi, Lei He, Yi Yan, Qijia Zhang, Shanshan Gong, Zhaojian Li, Guiyuan Zeng, Zhaoyang Wang, Fuyan Guo, Can Xiong, Wei |
author_sort | Hou, Xiangchan |
collection | PubMed |
description | Breast cancer is the most common malignant tumor in women, and its incidence is increasing each year. To effectively treat breast cancer, it is important to identify genes involved in its occurrence and development and to exploit them as potential drug therapy targets. Here, we found that potassium channel subfamily K member 6 (KCNK6) is significantly overexpressed in breast cancer, however, its function in tumors has not been reported. We further verified that KCNK6 expression is upregulated in breast cancer biopsies. Moreover, overexpressed KCNK6 was found to enhance the proliferation, invasion, and migration ability of breast cancer cells. These effects may occur by weakening cell adhesion and reducing cell hardness, thus affecting the malignant phenotype of breast cancer cells. Our study confirmed, for the first time, that increased KCNK6 expression in breast cancer cells may promote their proliferation, invasion, and migration. Moreover, considering that ion channels serve as therapeutic targets for many small molecular drugs in clinical treatment, targeting KCNK6 may represent a novel strategy for breast cancer therapies. Hence, the results of this study provide a theoretical basis for KCNK6 to become a potential molecular target for breast cancer treatment in the future. |
format | Online Article Text |
id | pubmed-8237943 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82379432021-06-29 Potassium Channel Protein KCNK6 Promotes Breast Cancer Cell Proliferation, Invasion, and Migration Hou, Xiangchan Tang, Le Li, Xiayu Xiong, Fang Mo, Yongzhen Jiang, Xianjie Deng, Xiangying Peng, Miao Wu, Pan Zhao, Mengyao Ouyang, Jiawei Shi, Lei He, Yi Yan, Qijia Zhang, Shanshan Gong, Zhaojian Li, Guiyuan Zeng, Zhaoyang Wang, Fuyan Guo, Can Xiong, Wei Front Cell Dev Biol Cell and Developmental Biology Breast cancer is the most common malignant tumor in women, and its incidence is increasing each year. To effectively treat breast cancer, it is important to identify genes involved in its occurrence and development and to exploit them as potential drug therapy targets. Here, we found that potassium channel subfamily K member 6 (KCNK6) is significantly overexpressed in breast cancer, however, its function in tumors has not been reported. We further verified that KCNK6 expression is upregulated in breast cancer biopsies. Moreover, overexpressed KCNK6 was found to enhance the proliferation, invasion, and migration ability of breast cancer cells. These effects may occur by weakening cell adhesion and reducing cell hardness, thus affecting the malignant phenotype of breast cancer cells. Our study confirmed, for the first time, that increased KCNK6 expression in breast cancer cells may promote their proliferation, invasion, and migration. Moreover, considering that ion channels serve as therapeutic targets for many small molecular drugs in clinical treatment, targeting KCNK6 may represent a novel strategy for breast cancer therapies. Hence, the results of this study provide a theoretical basis for KCNK6 to become a potential molecular target for breast cancer treatment in the future. Frontiers Media S.A. 2021-06-14 /pmc/articles/PMC8237943/ /pubmed/34195184 http://dx.doi.org/10.3389/fcell.2021.616784 Text en Copyright © 2021 Hou, Tang, Li, Xiong, Mo, Jiang, Deng, Peng, Wu, Zhao, Ouyang, Shi, He, Yan, Zhang, Gong, Li, Zeng, Wang, Guo and Xiong. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Hou, Xiangchan Tang, Le Li, Xiayu Xiong, Fang Mo, Yongzhen Jiang, Xianjie Deng, Xiangying Peng, Miao Wu, Pan Zhao, Mengyao Ouyang, Jiawei Shi, Lei He, Yi Yan, Qijia Zhang, Shanshan Gong, Zhaojian Li, Guiyuan Zeng, Zhaoyang Wang, Fuyan Guo, Can Xiong, Wei Potassium Channel Protein KCNK6 Promotes Breast Cancer Cell Proliferation, Invasion, and Migration |
title | Potassium Channel Protein KCNK6 Promotes Breast Cancer Cell Proliferation, Invasion, and Migration |
title_full | Potassium Channel Protein KCNK6 Promotes Breast Cancer Cell Proliferation, Invasion, and Migration |
title_fullStr | Potassium Channel Protein KCNK6 Promotes Breast Cancer Cell Proliferation, Invasion, and Migration |
title_full_unstemmed | Potassium Channel Protein KCNK6 Promotes Breast Cancer Cell Proliferation, Invasion, and Migration |
title_short | Potassium Channel Protein KCNK6 Promotes Breast Cancer Cell Proliferation, Invasion, and Migration |
title_sort | potassium channel protein kcnk6 promotes breast cancer cell proliferation, invasion, and migration |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8237943/ https://www.ncbi.nlm.nih.gov/pubmed/34195184 http://dx.doi.org/10.3389/fcell.2021.616784 |
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