Cargando…

Celastrol Modulates Multiple Signaling Pathways to Inhibit Proliferation of Pancreatic Cancer via DDIT3 and ATF3 Up-Regulation and RRM2 and MCM4 Down-Regulation

BACKGROUND: Pancreatic cancer is one of the most serious and lethal human cancers with a snowballing incidence around the world. The natural product celastrol has also been widely documented as a potent anti-inflammatory, anti-angiogenic, and anti-oxidant. PURPOSE: To elucidate the antitumor effect...

Descripción completa

Detalles Bibliográficos
Autores principales:	Youns, Mahmoud, Askoura, Momen, Abbas, Hisham A, Attia, Gouda H, Khayyat, Ahdab N, Goda, Reham M, Almalki, Ahmad J, Khafagy, El-Sayed, Hegazy, Wael A H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238076/ https://www.ncbi.nlm.nih.gov/pubmed/34194230 http://dx.doi.org/10.2147/OTT.S313933

Ejemplares similares

Secnidazole Is a Promising Imidazole Mitigator of Serratia marcescens Virulence
por: Khayyat, Ahdab N., et al.
Publicado: (2021)

Celastrol mitigates staphyloxanthin biosynthesis and biofilm formation in Staphylococcus aureus via targeting key regulators of virulence; in vitro and in vivo approach
por: Yehia, Fatma Al-zahraa A., et al.
Publicado: (2022)

Correction: Celastrol mitigates staphyloxanthin biosynthesis and biofilm formation in Staphylococcus aureus via targeting key regulators of virulence; in vitro and in vivo approach
por: Yehia, Fatma Al-zahraa A., et al.
Publicado: (2022)

In vitro activity of celastrol in combination with thymol against carbapenem-resistant Klebsiella pneumoniae isolates
por: Abdel-Halim, Mahmoud Saad, et al.
Publicado: (2022)

Knockdown of TBRG4 affects tumorigenesis in human H1299 lung cancer cells by regulating DDIT3, CAV1 and RRM2
por: Wang, Ansheng, et al.
Publicado: (2018)

Alteration of Salmonella enterica Virulence and Host Pathogenesis through Targeting sdiA by Using the CRISPR-Cas9 System
por: Askoura, Momen, et al.
Publicado: (2021)

Xylitol Inhibits Growth and Blocks Virulence in Serratia marcescens
por: Khayyat, Ahdab N., et al.
Publicado: (2021)

Hiring of the Anti-Quorum Sensing Activities of Hypoglycemic Agent Linagliptin to Alleviate the Pseudomonas aeruginosa Pathogenesis
por: Khayat, Maan T., et al.
Publicado: (2022)

Elevated Levels of IL-33, IL-17 and IL-25 Indicate the Progression from Chronicity to Hepatocellular Carcinoma in Hepatitis C Virus Patients
por: Askoura, Momen, et al.
Publicado: (2022)

Anti-Quorum Sensing Activities of Gliptins against Pseudomonas aeruginosa and Staphylococcus aureus
por: Khayat, Maan T., et al.
Publicado: (2022)

Sodium Citrate Alleviates Virulence in Pseudomonas aeruginosa
por: Khayat, Maan T., et al.
Publicado: (2022)

Up‐regulation of DDIT4 predicts poor prognosis in acute myeloid leukaemia
por: Cheng, Zhiheng, et al.
Publicado: (2019)

Long Non-coding Antisense RNA DDIT4-AS1 Regulates Meningitic Escherichia coli-Induced Neuroinflammation by Promoting DDIT4 mRNA Stability
por: Yang, Bo, et al.
Publicado: (2022)

Ultra-performance liquid chromatography-tandem mass spectrometric method for quantitation of the recently Food and Drug Administration approved combination of vaborbactam and meropenem in human plasma
por: Kammoun, Ahmed K., et al.
Publicado: (2020)

Opposite modulation of functional recovery following contusive spinal cord injury in mice with oligodendrocyte-selective deletions of Atf4 and Chop/Ddit3
por: Gao, Yonglin, et al.
Publicado: (2023)

DDIT3 Expression in Liposarcoma Development
por: Kåbjörn Gustafsson, Christina, et al.
Publicado: (2014)

Tackling Virulence of Pseudomonas aeruginosa by the Natural Furanone Sotolon
por: Aldawsari, Mohammed F., et al.
Publicado: (2021)

Single-Cell Network Analysis Identifies DDIT3 as a Nodal Lineage Regulator in Hematopoiesis
por: Pina, Cristina, et al.
Publicado: (2015)

A review of the mechanism of DDIT4 serve as a mitochondrial related protein in tumor regulation
por: Ding, Fadian, et al.
Publicado: (2021)

Celastrol promotes chondrocyte autophagy by regulating mTOR expression
por: Dai, Siming, et al.
Publicado: (2022)

Regulating mitochondrial homeostasis and inhibiting inflammatory responses through Celastrol
por: Tao, Zhenyu, et al.
Publicado: (2022)

Histone chaperones and the Rrm3p helicase regulate flocculation in S. cerevisiae
por: Rowlands, Hollie, et al.
Publicado: (2019)

HPLC Determination of Imidazoles with Variant Anti-Infective Activity in Their Dosage Forms and Human Plasma
por: Ali, Oday T., et al.
Publicado: (2020)

The FUS-DDIT3 Interactome in Myxoid Liposarcoma()
por: Yu, Jamie S.E., et al.
Publicado: (2019)

DDIT4 Novel Mutations in Pancreatic Cancer
por: Ding, Fadian, et al.
Publicado: (2021)

DDIT3/CHOP and the sarcoma fusion oncoprotein FUS-DDIT3/TLS-CHOP bind cyclin-dependent kinase 2
por: Bento, Christoffer, et al.
Publicado: (2009)

Functional insights into the interplay between DNA interaction and metal coordination in ferric uptake regulators
por: Sarvan, Sabina, et al.
Publicado: (2018)

Synergistic Benefits: Exploring the Anti-Virulence Effects of Metformin/Vildagliptin Antidiabetic Combination against Pseudomonas aeruginosa via Controlling Quorum Sensing Systems
por: Khayat, Maan T., et al.
Publicado: (2023)

A Cytoplasmic Negative Regulator Isoform of ATF7 Impairs ATF7 and ATF2 Phosphorylation and Transcriptional Activity
por: Diring, Jessica, et al.
Publicado: (2011)

DDIT3 antagonizes innate immune response to promote bovine alphaherpesvirus 1 replication via the DDIT3-SQSTM1-STING pathway
por: Wang, Song, et al.
Publicado: (2022)

Zinc oxide nanoparticles reduce biofilm formation, synergize antibiotics action and attenuate Staphylococcus aureus virulence in host; an important message to clinicians
por: Abdelghafar, Aliaa, et al.
Publicado: (2022)

RRM1 *151A>T, RRM1 ‐756T>C, and RRM1 ‐585T>Gis associated with increased susceptibility of lung cancer in Chinese patients
por: Xu, Xiao‐Ling, et al.
Publicado: (2016)

Antiviral zinc oxide nanoparticles mediated by hesperidin and in silico comparison study between antiviral phenolics as anti-SARS-CoV-2
por: Attia, Gouda H., et al.
Publicado: (2021)

Differential Interactions of the Autonomous Pathway RRM Proteins and Chromatin Regulators in the Silencing of Arabidopsis Targets
por: Bäurle, Isabel, et al.
Publicado: (2008)

RRM2B-Mediated Regulation of Mitochondrial Activity and Inflammation under Oxidative Stress
por: Cho, Er-Chieh, et al.
Publicado: (2015)

Direct inhibition of c-Myc-Max heterodimers by celastrol and celastrol-inspired triterpenoids
por: Wang, Huabo, et al.
Publicado: (2015)

Systematic identification of Celastrol-binding proteins reveals that Shoc2 is inhibited by Celastrol
por: Xiao-pei, Huang, et al.
Publicado: (2018)

Zinc oxide nanoparticles inhibits quorum sensing and virulence in Pseudomonas aeruginosa
por: Saleh, Moustafa M, et al.
Publicado: (2019)

DDIT4 regulates mesenchymal stem cell fate by mediating between HIF1α and mTOR signalling
por: Gharibi, Borzo, et al.
Publicado: (2016)

An integrative transcriptome study reveals Ddit4/Redd1 as a key regulator of cancer cachexia in rodent models
por: Niu, Mengyuan, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_m9m5jd6dgbp3jvpafntudo23ka