SARS-CoV-2 Infection Inducing Immune Thrombocytopenic Purpura: Case Series

Background: Immune thrombocytopenic purpura (ITP) refers to immune-mediated destruction of platelets. Viral infections have been proposed as an etiology of ITP; antibodies developed in response to infection may cross-react with normal platelets and result in their destruction. Case Series: We report...

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Autores principales: Guirguis, Nancy, Rehman, Tyler, Shams, Yara, Gordon, Melanie, Mekhaiel, Essam, Rozell, Shaina, Pandya, Mauna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Division of Ochsner Clinic Foundation 2021
Materias:
Case Reports and Clinical Observations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238109/
https://www.ncbi.nlm.nih.gov/pubmed/34239380
http://dx.doi.org/10.31486/toj.20.0100
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author Guirguis, Nancy
Rehman, Tyler
Shams, Yara
Gordon, Melanie
Mekhaiel, Essam
Rozell, Shaina
Pandya, Mauna
author_facet Guirguis, Nancy
Rehman, Tyler
Shams, Yara
Gordon, Melanie
Mekhaiel, Essam
Rozell, Shaina
Pandya, Mauna
author_sort Guirguis, Nancy
collection PubMed
description Background: Immune thrombocytopenic purpura (ITP) refers to immune-mediated destruction of platelets. Viral infections have been proposed as an etiology of ITP; antibodies developed in response to infection may cross-react with normal platelets and result in their destruction. Case Series: We report 2 cases in which coronavirus disease 2019 (COVID-19) likely induced severe ITP. Conclusion: ITP may also play a role in the thrombocytopenia observed in some patients with COVID-19. ITP in this patient population may be more prevalent than currently documented.
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spelling pubmed-82381092021-07-07 SARS-CoV-2 Infection Inducing Immune Thrombocytopenic Purpura: Case Series Guirguis, Nancy Rehman, Tyler Shams, Yara Gordon, Melanie Mekhaiel, Essam Rozell, Shaina Pandya, Mauna Ochsner J Case Reports and Clinical Observations Background: Immune thrombocytopenic purpura (ITP) refers to immune-mediated destruction of platelets. Viral infections have been proposed as an etiology of ITP; antibodies developed in response to infection may cross-react with normal platelets and result in their destruction. Case Series: We report 2 cases in which coronavirus disease 2019 (COVID-19) likely induced severe ITP. Conclusion: ITP may also play a role in the thrombocytopenia observed in some patients with COVID-19. ITP in this patient population may be more prevalent than currently documented. Academic Division of Ochsner Clinic Foundation 2021 2021 /pmc/articles/PMC8238109/ /pubmed/34239380 http://dx.doi.org/10.31486/toj.20.0100 Text en ©2021 by the author(s); Creative Commons Attribution License (CC BY) https://creativecommons.org/licenses/by/4.0/©2021 by the author(s); licensee Ochsner Journal, Ochsner Clinic Foundation, New Orleans, LA. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (creativecommons.org/licenses/by/4.0/legalcode) that permits unrestricted use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Case Reports and Clinical Observations
Guirguis, Nancy
Rehman, Tyler
Shams, Yara
Gordon, Melanie
Mekhaiel, Essam
Rozell, Shaina
Pandya, Mauna
SARS-CoV-2 Infection Inducing Immune Thrombocytopenic Purpura: Case Series
title SARS-CoV-2 Infection Inducing Immune Thrombocytopenic Purpura: Case Series
title_full SARS-CoV-2 Infection Inducing Immune Thrombocytopenic Purpura: Case Series
title_fullStr SARS-CoV-2 Infection Inducing Immune Thrombocytopenic Purpura: Case Series
title_full_unstemmed SARS-CoV-2 Infection Inducing Immune Thrombocytopenic Purpura: Case Series
title_short SARS-CoV-2 Infection Inducing Immune Thrombocytopenic Purpura: Case Series
title_sort sars-cov-2 infection inducing immune thrombocytopenic purpura: case series
topic Case Reports and Clinical Observations
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238109/
https://www.ncbi.nlm.nih.gov/pubmed/34239380
http://dx.doi.org/10.31486/toj.20.0100
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