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The relationship of pre-corneal to pre-contact lens non-invasive tear breakup time

PURPOSE: To examine the relationship between pre-corneal and pre-contact lens tear film stability (TFS), and to determine whether pre-corneal TFS is a reliable predictor of subsequent pre-lens TFS after a contact lens is placed on the eye. METHODS: 667 records met inclusion criteria and were extract...

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Autores principales: Graham, Andrew D., Lin, Meng C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238214/
https://www.ncbi.nlm.nih.gov/pubmed/34181641
http://dx.doi.org/10.1371/journal.pone.0247877
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author Graham, Andrew D.
Lin, Meng C.
author_facet Graham, Andrew D.
Lin, Meng C.
author_sort Graham, Andrew D.
collection PubMed
description PURPOSE: To examine the relationship between pre-corneal and pre-contact lens tear film stability (TFS), and to determine whether pre-corneal TFS is a reliable predictor of subsequent pre-lens TFS after a contact lens is placed on the eye. METHODS: 667 records met inclusion criteria and were extracted from a soft contact lens multi-study database. Multivariable linear mixed effects models were fit to examine the association between pre-corneal and pre-lens TFS, adjusting for potential confounders and accounting for repeated measures. Receiver Operating Characteristic (ROC) analysis was employed to assess the predictive performance of pre-corneal TFS for subsequent pre-lens TFS. TFS was quantified for this analysis as the non-invasive tear breakup time (NITBUT). RESULTS: Pre-corneal NITBUT was significantly related to the pre-lens NITBUT at both 10 min (p<0.001) and 2–6 hrs (p<0.001) post-lens insertion. However, the sensitivities of pre-corneal NITBUT for predicting symptom-associated thresholds of pre-lens NITBUT ranged from 50–65%, and specificities ranged from 57–72%, suggesting poor-to-moderate diagnostic performance. CONCLUSIONS: Despite the association of pre-corneal and pre-lens TFS, the inherent lability and sensitivity to environmental exposures of the tear film introduce significant variability into NITBUT measurements. Using pre-corneal NITBUT to identify likely successful contact lens candidates prior to fitting is thus not sufficiently accurate to be relied upon in the clinical setting.
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spelling pubmed-82382142021-07-09 The relationship of pre-corneal to pre-contact lens non-invasive tear breakup time Graham, Andrew D. Lin, Meng C. PLoS One Research Article PURPOSE: To examine the relationship between pre-corneal and pre-contact lens tear film stability (TFS), and to determine whether pre-corneal TFS is a reliable predictor of subsequent pre-lens TFS after a contact lens is placed on the eye. METHODS: 667 records met inclusion criteria and were extracted from a soft contact lens multi-study database. Multivariable linear mixed effects models were fit to examine the association between pre-corneal and pre-lens TFS, adjusting for potential confounders and accounting for repeated measures. Receiver Operating Characteristic (ROC) analysis was employed to assess the predictive performance of pre-corneal TFS for subsequent pre-lens TFS. TFS was quantified for this analysis as the non-invasive tear breakup time (NITBUT). RESULTS: Pre-corneal NITBUT was significantly related to the pre-lens NITBUT at both 10 min (p<0.001) and 2–6 hrs (p<0.001) post-lens insertion. However, the sensitivities of pre-corneal NITBUT for predicting symptom-associated thresholds of pre-lens NITBUT ranged from 50–65%, and specificities ranged from 57–72%, suggesting poor-to-moderate diagnostic performance. CONCLUSIONS: Despite the association of pre-corneal and pre-lens TFS, the inherent lability and sensitivity to environmental exposures of the tear film introduce significant variability into NITBUT measurements. Using pre-corneal NITBUT to identify likely successful contact lens candidates prior to fitting is thus not sufficiently accurate to be relied upon in the clinical setting. Public Library of Science 2021-06-28 /pmc/articles/PMC8238214/ /pubmed/34181641 http://dx.doi.org/10.1371/journal.pone.0247877 Text en © 2021 Graham, Lin https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Graham, Andrew D.
Lin, Meng C.
The relationship of pre-corneal to pre-contact lens non-invasive tear breakup time
title The relationship of pre-corneal to pre-contact lens non-invasive tear breakup time
title_full The relationship of pre-corneal to pre-contact lens non-invasive tear breakup time
title_fullStr The relationship of pre-corneal to pre-contact lens non-invasive tear breakup time
title_full_unstemmed The relationship of pre-corneal to pre-contact lens non-invasive tear breakup time
title_short The relationship of pre-corneal to pre-contact lens non-invasive tear breakup time
title_sort relationship of pre-corneal to pre-contact lens non-invasive tear breakup time
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238214/
https://www.ncbi.nlm.nih.gov/pubmed/34181641
http://dx.doi.org/10.1371/journal.pone.0247877
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