Cargando…

Oncogenic transformation of NIH/3T3 cells by the overexpression of L-type amino acid transporter 1, a promising anti-cancer target

L-type amino acid transporter 1 (LAT1)/SLC7A5 is the first identified CD98 light chain disulfide linked to the CD98 heavy chain (CD98hc/SLC3A2). LAT1 transports large neutral amino acids, including leucine, which activates mTOR, and is highly expressed in human cancers. We investigated the oncogenic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hayashi, Natsumi, Yamasaki, Akitaka, Ueda, Shiho, Okazaki, Shogo, Ohno, Yoshiya, Tanaka, Toshiyuki, Endo, Yuichi, Tomioka, Yoshihisa, Masuko, Kazue, Masuko, Takashi, Sugiura, Reiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238248/ https://www.ncbi.nlm.nih.gov/pubmed/34194623 http://dx.doi.org/10.18632/oncotarget.27981

Ejemplares similares

Dual‐targeting therapy against HER3/MET in human colorectal cancers
por: Yamasaki, Akitaka, et al.
Publicado: (2023)

Anti‐tumor effects of an antagonistic mAb against the ASCT2 amino acid transporter on KRAS‐mutated human colorectal cancer cells
por: Hara, Yuta, et al.
Publicado: (2019)

Novel functional anti-HER3 monoclonal antibodies with potent anti-cancer effects on various human epithelial cancers
por: Okita, Kouki, et al.
Publicado: (2020)

Inhibition of tumor formation and metastasis by a monoclonal antibody against lymphatic vessel endothelial hyaluronan receptor 1
por: Hara, Yuta, et al.
Publicado: (2018)

Antitumor effects of novel mAbs against cationic amino acid transporter 1 (CAT1) on human CRC with amplified CAT1 gene
por: Okita, Kouki, et al.
Publicado: (2020)

Sip1, an AP-1 Accessory Protein in Fission Yeast, Is Required for Localization of Rho3 GTPase
por: Yu, Yang, et al.
Publicado: (2013)

Experimental Metastasis of Oncogene‐transformed NIH 3T3 Cells in Chick Embryo
por: Endo, Yoshio, et al.
Publicado: (1992)

Anti‐tumor effects of mAb against l‐type amino acid transporter 1 (LAT1) bound to human and monkey LAT1 with dual avidity modes
por: Ueda, Shiho, et al.
Publicado: (2019)

Optimisation of conditions for detection of activated oncogenes by transfection of NIH 3T3 cells.
por: Lemoine, N. R., et al.
Publicado: (1987)

PML suppresses oncogenic transformation of NIH/3T3 cells by activated neu
Publicado: (1995)

Anti-Tumor Effect against Human Cancer Xenografts by a Fully Human Monoclonal Antibody to a Variant 8-Epitope of CD44R1 Expressed on Cancer Stem Cells
por: Masuko, Kazue, et al.
Publicado: (2012)

Selective activation of oncogenic Ha-ras-induced apoptosis in NIH/3T3 cells
Publicado: (1998)

Selective activation of oncogenic Ha-ras-induced apoptosis in NIH/3T3 cells.
por: Liu, H. S., et al.
Publicado: (1998)

The enhanced transfer of drug-resistant genes in NIH-3T3 cells transformed by the EJras oncogene.
por: Wong, D., et al.
Publicado: (1988)

OVA66, a Tumor Associated Protein, Induces Oncogenic Transformation of NIH3T3 Cells
por: Rao, Wei, et al.
Publicado: (2014)

CD44 variant‐dependent redox status regulation in liver fluke‐associated cholangiocarcinoma: A target for cholangiocarcinoma treatment
por: Thanee, Malinee, et al.
Publicado: (2016)

Expression of oncogenic HRAS (G12V) causes defects in control of cell size in NIH 3T3 cells
por: DeWitt, Jerry T., et al.
Publicado: (2023)

Imaging the L-Type Amino Acid Transporter-1 (LAT1) with Zr-89 ImmunoPET
por: Ikotun, Oluwatayo F., et al.
Publicado: (2013)

In vitro Targeting and Cytotoxicity of Adriamycin in Liposomes Bearing Monoclonal Antibody against Rat or Human gp125 Cell Proliferation‐associated Antigen
por: Tanaka, Toshiyuki, et al.
Publicado: (1989)

Midkine induces the transformation of NIH3T3 cells.
por: Kadomatsu, K., et al.
Publicado: (1997)

Heterogeneity of the NIH3T3 Fibroblast Cell Line
por: Rahimi, Amir Mohammad, et al.
Publicado: (2022)

β-Cryptoxanthin Alleviates Diet-Induced Nonalcoholic Steatohepatitis by Suppressing Inflammatory Gene Expression in Mice
por: Kobori, Masuko, et al.
Publicado: (2014)

A Novel Tetracyclic Peptide, Trapoxin, Induces Phenotypic Change from Transformed to Normal in sis‐Oncogene‐transformed NIH3T3 Cells
por: Yoshida, Hiroshi, et al.
Publicado: (1992)

Repeated lipopolysaccharide exposure causes corticosteroid insensitive airway inflammation via activation of phosphoinositide-3-kinase δ pathway
por: Ueda, Keitaro, et al.
Publicado: (2016)

Rheumatoid Cachexia Revisited: A Metabolic Co-Morbidity in Rheumatoid Arthritis
por: Masuko, Kayo
Publicado: (2014)

A Potential Benefit of “Balanced Diet” for Rheumatoid Arthritis
por: Masuko, Kayo
Publicado: (2018)

Glucose as a Potential Key to Fuel Inflammation in Rheumatoid Arthritis
por: Masuko, Kayo
Publicado: (2022)

Fingolimod (FTY720) Stimulates Ca(2+)/Calcineurin Signaling in Fission Yeast
por: Hagihara, Kanako, et al.
Publicado: (2013)

c-Ha-rasVal 12 oncogene-transformed NIH-3T3 fibroblasts display more decondensed nucleosomal organization than normal fibroblasts
Publicado: (1990)

Exposure to airborne PM(2.5) suppresses microRNA expression and deregulates target oncogenes that cause neoplastic transformation in NIH3T3 cells
por: Liu, Chunling, et al.
Publicado: (2015)

Glutaminolysis‐related genes determine sensitivity to xCT‐targeted therapy in head and neck squamous cell carcinoma
por: Okazaki, Shogo, et al.
Publicado: (2019)

Gene Expression Patterns of Hemizygous and Heterozygous KIT Mutations Suggest Distinct Oncogenic Pathways: A Study in NIH3T3 Cell Lines and GIST Samples
por: Bachet, Jean-Baptiste, et al.
Publicado: (2013)

Molecular genetics and targeted therapy of WNT-related human diseases (Review)
por: Katoh, Masuko, et al.
Publicado: (2017)

Precision medicine for human cancers with Notch signaling dysregulation (Review)
por: Katoh, Masuko, et al.
Publicado: (2020)

WNT signaling and cancer stemness
por: Katoh, Masuko, et al.
Publicado: (2022)

Adhesion, Proliferation and Migration of NIH/3T3 Cells on Modified Polyaniline Surfaces
por: Rejmontová, Petra, et al.
Publicado: (2016)

Transformation of NIH3T3 Cells with Synthetic c‐Ha‐ras Genes
por: Kamiya, Hiroyuki, et al.
Publicado: (1989)

Apoptotic Effect of 1800 MHz Electromagnetic Radiation on NIH/3T3 Cells
por: Li, Dan-Yang, et al.
Publicado: (2020)

Continuous intake of quercetin-rich onion powder may improve emotion but not regional cerebral blood flow in subjects with cognitive impairment
por: Hayashi, Yuichi, et al.
Publicado: (2023)

Cross-Talk between NADPH Oxidase and Mitochondria: Role in ROS Signaling and Angiogenesis
por: Fukai, Tohru, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_otd9mv2tik6m0tbktpr2s22o76