Comprehensive Breast Cancer Risk Assessment for CHEK2 and ATM Pathogenic Variant Carriers Incorporating a Polygenic Risk Score and the Tyrer-Cuzick Model

PURPOSE: Breast cancer risks for CHEK2 and ATM pathogenic variant (PV) carriers are modified by an 86-single nucleotide polymorphism polygenic risk score (PRS) and individual clinical factors. Here, we describe comprehensive risk prediction models for women of European ancestry combining PV status,...

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Detalles Bibliográficos
Autores principales: Gallagher, Shannon, Hughes, Elisha, Kurian, Allison W., Domchek, Susan M., Garber, Judy, Probst, Braden, Morris, Brian, Tshiaba, Placede, Meek, Stephanie, Rosenthal, Eric, Roa, Benjamin, Slavin, Thomas P., Wagner, Susanne, Weitzel, Jeffrey, Gutin, Alexander, Lanchbury, Jerry S., Robson, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2021
Materias:
ORIGINAL REPORTS
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238281/
https://www.ncbi.nlm.nih.gov/pubmed/34322652
http://dx.doi.org/10.1200/PO.20.00484

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238281/
https://www.ncbi.nlm.nih.gov/pubmed/34322652
http://dx.doi.org/10.1200/PO.20.00484

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