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Treatments of unruptured brain arteriovenous malformations: A systematic review and meta-analysis
BACKGROUND: The best therapeutic option for unruptured brain arteriovenous malformations (bAVMs) patients is disputed. OBJECTIVE: To assess the occurrence of obliteration and complications of patients with unruptured bAVMs after various treatments. METHODS: A systematic literature search was perform...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238300/ https://www.ncbi.nlm.nih.gov/pubmed/34160402 http://dx.doi.org/10.1097/MD.0000000000026352 |
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author | Liu, Renjie Zhan, Yongle Piao, Jianmin Yang, Zhongxi Wei, Yun Liu, Pengcheng Chen, Xuan Jiang, Yu |
author_facet | Liu, Renjie Zhan, Yongle Piao, Jianmin Yang, Zhongxi Wei, Yun Liu, Pengcheng Chen, Xuan Jiang, Yu |
author_sort | Liu, Renjie |
collection | PubMed |
description | BACKGROUND: The best therapeutic option for unruptured brain arteriovenous malformations (bAVMs) patients is disputed. OBJECTIVE: To assess the occurrence of obliteration and complications of patients with unruptured bAVMs after various treatments. METHODS: A systematic literature search was performed in PubMed, EMBASE, Web of Science, and so on to identify studies fulfilling predefined inclusion criteria. Baseline, treatment, and outcomes data were extracted for statistical analysis. RESULTS: We identified 28 eligible studies totaling 5852 patients. The obliteration rates were 98% in microsurgery group (95% confidence interval (CI): 96%–99%, I(2) = 74.5%), 97% in surgery group (95%CI: 95%–99%, I(2) = 18.3%), 87% in endovascular treatment group (95%CI: 80%–93%, I(2) = 0.0%), and 68% in radiosurgery group (95%CI: 66%–69%, I(2) = 92.0%). The stroke or death rates were 1% in microsurgery group (95%CI: 0%–2%, I(2) = 0.0%), 0% in surgery group (95%CI: 0%–1%, I(2) = 0.0%), 4% in endovascular treatment group (95%CI: 0%–8%, I(2) = 85.8%), and 3% in radiosurgery group (95%CI: 3%–4%, I(2) = 82.9%). In addition, the proportions of hemorrhage were 2% in microsurgery group (95%CI: 1%–4%, I(2) = 0.0%), 23% in endovascular treatment group (95%CI: 7%–39%), and 12% in radiosurgery group (95%CI: 12%–13%, I(2) = 99.2%). As to neurological deficit, the occurrence was 9% in microsurgery group (95%CI: 6%–11%, I(2) = 94.1%), 20% in surgery group (95%CI: 13%–27%, I(2) = 0.0%), 14% in endovascular treatment group (95%CI: 10%–18%, I(2) = 64.0%), and 8% in radiosurgery group (95%CI: 7%–9%, I(2) = 66.6%). CONCLUSIONS: We found that microsurgery might provide lasting clinical benefits in some unruptured bAVMs patients for its high obliteration rates and low hemorrhage. These findings are helpful to provide a reference basis for neurosurgeons to choose the treatment of patients with unruptured bAVMs. |
format | Online Article Text |
id | pubmed-8238300 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-82383002021-07-06 Treatments of unruptured brain arteriovenous malformations: A systematic review and meta-analysis Liu, Renjie Zhan, Yongle Piao, Jianmin Yang, Zhongxi Wei, Yun Liu, Pengcheng Chen, Xuan Jiang, Yu Medicine (Baltimore) 7100 BACKGROUND: The best therapeutic option for unruptured brain arteriovenous malformations (bAVMs) patients is disputed. OBJECTIVE: To assess the occurrence of obliteration and complications of patients with unruptured bAVMs after various treatments. METHODS: A systematic literature search was performed in PubMed, EMBASE, Web of Science, and so on to identify studies fulfilling predefined inclusion criteria. Baseline, treatment, and outcomes data were extracted for statistical analysis. RESULTS: We identified 28 eligible studies totaling 5852 patients. The obliteration rates were 98% in microsurgery group (95% confidence interval (CI): 96%–99%, I(2) = 74.5%), 97% in surgery group (95%CI: 95%–99%, I(2) = 18.3%), 87% in endovascular treatment group (95%CI: 80%–93%, I(2) = 0.0%), and 68% in radiosurgery group (95%CI: 66%–69%, I(2) = 92.0%). The stroke or death rates were 1% in microsurgery group (95%CI: 0%–2%, I(2) = 0.0%), 0% in surgery group (95%CI: 0%–1%, I(2) = 0.0%), 4% in endovascular treatment group (95%CI: 0%–8%, I(2) = 85.8%), and 3% in radiosurgery group (95%CI: 3%–4%, I(2) = 82.9%). In addition, the proportions of hemorrhage were 2% in microsurgery group (95%CI: 1%–4%, I(2) = 0.0%), 23% in endovascular treatment group (95%CI: 7%–39%), and 12% in radiosurgery group (95%CI: 12%–13%, I(2) = 99.2%). As to neurological deficit, the occurrence was 9% in microsurgery group (95%CI: 6%–11%, I(2) = 94.1%), 20% in surgery group (95%CI: 13%–27%, I(2) = 0.0%), 14% in endovascular treatment group (95%CI: 10%–18%, I(2) = 64.0%), and 8% in radiosurgery group (95%CI: 7%–9%, I(2) = 66.6%). CONCLUSIONS: We found that microsurgery might provide lasting clinical benefits in some unruptured bAVMs patients for its high obliteration rates and low hemorrhage. These findings are helpful to provide a reference basis for neurosurgeons to choose the treatment of patients with unruptured bAVMs. Lippincott Williams & Wilkins 2021-06-25 /pmc/articles/PMC8238300/ /pubmed/34160402 http://dx.doi.org/10.1097/MD.0000000000026352 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) |
spellingShingle | 7100 Liu, Renjie Zhan, Yongle Piao, Jianmin Yang, Zhongxi Wei, Yun Liu, Pengcheng Chen, Xuan Jiang, Yu Treatments of unruptured brain arteriovenous malformations: A systematic review and meta-analysis |
title | Treatments of unruptured brain arteriovenous malformations: A systematic review and meta-analysis |
title_full | Treatments of unruptured brain arteriovenous malformations: A systematic review and meta-analysis |
title_fullStr | Treatments of unruptured brain arteriovenous malformations: A systematic review and meta-analysis |
title_full_unstemmed | Treatments of unruptured brain arteriovenous malformations: A systematic review and meta-analysis |
title_short | Treatments of unruptured brain arteriovenous malformations: A systematic review and meta-analysis |
title_sort | treatments of unruptured brain arteriovenous malformations: a systematic review and meta-analysis |
topic | 7100 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238300/ https://www.ncbi.nlm.nih.gov/pubmed/34160402 http://dx.doi.org/10.1097/MD.0000000000026352 |
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