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HIV viral exposure and mortality in a multicenter ambulatory HIV adult cohort, United States, 1995–2016

The aim of this study was to identify viral exposure (VE) measures and their relationship to mortality risk among persons with HIV. Prospective multicenter observational study to compare VE formulae. Eligible participants initiated first combination antiretroviral therapy (cART) between March 1, 199...

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Autores principales: Palella, Frank J., Armon, Carl, Cole, Stephen R., Hart, Rachel, Tedaldi, Ellen, Novak, Richard, Battalora, Linda, Purinton, Stacey, Li, Jun, Buchacz, Kate
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238313/
https://www.ncbi.nlm.nih.gov/pubmed/34160393
http://dx.doi.org/10.1097/MD.0000000000026285
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author Palella, Frank J.
Armon, Carl
Cole, Stephen R.
Hart, Rachel
Tedaldi, Ellen
Novak, Richard
Battalora, Linda
Purinton, Stacey
Li, Jun
Buchacz, Kate
author_facet Palella, Frank J.
Armon, Carl
Cole, Stephen R.
Hart, Rachel
Tedaldi, Ellen
Novak, Richard
Battalora, Linda
Purinton, Stacey
Li, Jun
Buchacz, Kate
author_sort Palella, Frank J.
collection PubMed
description The aim of this study was to identify viral exposure (VE) measures and their relationship to mortality risk among persons with HIV. Prospective multicenter observational study to compare VE formulae. Eligible participants initiated first combination antiretroviral therapy (cART) between March 1, 1995 and June 30, 2015. We included 1645 participants followed for ≥6 months after starting first cART, with cART prescribed ≥75% of time, who underwent ≥2 plasma viral load (VL) and ≥1 CD4+ T-lymphocyte cell (CD4) measurement during observation. We evaluated all-cause mortality from 6 months after cART initiation until June 30, 2016. VE was quantified using 2 time-updated variables: viremia copy-years and percent of person-years (%PY) spent >200 or 50 copies/mL. Cox models were fit to estimate associations between VE and mortality. Participants contributed 10,453 person years [py], with median 14 VLs per patient. Median %PY >200 or >50 were 10% (interquartile range: 1%–47%) and 26% (interquartile range: 6%–72%), respectively. There were 115 deaths, for an overall mortality rate of 1.19 per 100 person years. In univariate models, each measure of VE was significantly associated with mortality risk, as were older age, public insurance, injection drug use HIV risk history, and lower pre-cART CD4. Based on model fit, most recent viral load and %PY >200 copies/mL provided the best combination of VE factors to predict mortality, although all VE combinations evaluated performed well. The combination of most recent VL and %PY >200 copies/mL best predicted mortality, although all evaluated VE measures performed well.
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spelling pubmed-82383132021-07-06 HIV viral exposure and mortality in a multicenter ambulatory HIV adult cohort, United States, 1995–2016 Palella, Frank J. Armon, Carl Cole, Stephen R. Hart, Rachel Tedaldi, Ellen Novak, Richard Battalora, Linda Purinton, Stacey Li, Jun Buchacz, Kate Medicine (Baltimore) 4850 The aim of this study was to identify viral exposure (VE) measures and their relationship to mortality risk among persons with HIV. Prospective multicenter observational study to compare VE formulae. Eligible participants initiated first combination antiretroviral therapy (cART) between March 1, 1995 and June 30, 2015. We included 1645 participants followed for ≥6 months after starting first cART, with cART prescribed ≥75% of time, who underwent ≥2 plasma viral load (VL) and ≥1 CD4+ T-lymphocyte cell (CD4) measurement during observation. We evaluated all-cause mortality from 6 months after cART initiation until June 30, 2016. VE was quantified using 2 time-updated variables: viremia copy-years and percent of person-years (%PY) spent >200 or 50 copies/mL. Cox models were fit to estimate associations between VE and mortality. Participants contributed 10,453 person years [py], with median 14 VLs per patient. Median %PY >200 or >50 were 10% (interquartile range: 1%–47%) and 26% (interquartile range: 6%–72%), respectively. There were 115 deaths, for an overall mortality rate of 1.19 per 100 person years. In univariate models, each measure of VE was significantly associated with mortality risk, as were older age, public insurance, injection drug use HIV risk history, and lower pre-cART CD4. Based on model fit, most recent viral load and %PY >200 copies/mL provided the best combination of VE factors to predict mortality, although all VE combinations evaluated performed well. The combination of most recent VL and %PY >200 copies/mL best predicted mortality, although all evaluated VE measures performed well. Lippincott Williams & Wilkins 2021-06-25 /pmc/articles/PMC8238313/ /pubmed/34160393 http://dx.doi.org/10.1097/MD.0000000000026285 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle 4850
Palella, Frank J.
Armon, Carl
Cole, Stephen R.
Hart, Rachel
Tedaldi, Ellen
Novak, Richard
Battalora, Linda
Purinton, Stacey
Li, Jun
Buchacz, Kate
HIV viral exposure and mortality in a multicenter ambulatory HIV adult cohort, United States, 1995–2016
title HIV viral exposure and mortality in a multicenter ambulatory HIV adult cohort, United States, 1995–2016
title_full HIV viral exposure and mortality in a multicenter ambulatory HIV adult cohort, United States, 1995–2016
title_fullStr HIV viral exposure and mortality in a multicenter ambulatory HIV adult cohort, United States, 1995–2016
title_full_unstemmed HIV viral exposure and mortality in a multicenter ambulatory HIV adult cohort, United States, 1995–2016
title_short HIV viral exposure and mortality in a multicenter ambulatory HIV adult cohort, United States, 1995–2016
title_sort hiv viral exposure and mortality in a multicenter ambulatory hiv adult cohort, united states, 1995–2016
topic 4850
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238313/
https://www.ncbi.nlm.nih.gov/pubmed/34160393
http://dx.doi.org/10.1097/MD.0000000000026285
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