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Pyloric gland adenoma with low-grade intraepithelial neoplasia: A case report and literature review

RATIONALE: Pyloric gland adenoma (PGA) is often associated with pyloric gland metaplasia. It has high malignant potential but a low clinical diagnosis rate. Therefore, we reported a case of PGA and reviewed the literature to summarize the clinicopathological features of pyloric adenoma. PATIENT CONC...

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Autores principales: Li, Hai-Long, Wang, Yan, Ren, Yu-Bo, Yang, Xue-Song, Wang, Li, Zhang, Lei, Lin, Xiang-Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238336/
https://www.ncbi.nlm.nih.gov/pubmed/34160413
http://dx.doi.org/10.1097/MD.0000000000026378
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author Li, Hai-Long
Wang, Yan
Ren, Yu-Bo
Yang, Xue-Song
Wang, Li
Zhang, Lei
Lin, Xiang-Chun
author_facet Li, Hai-Long
Wang, Yan
Ren, Yu-Bo
Yang, Xue-Song
Wang, Li
Zhang, Lei
Lin, Xiang-Chun
author_sort Li, Hai-Long
collection PubMed
description RATIONALE: Pyloric gland adenoma (PGA) is often associated with pyloric gland metaplasia. It has high malignant potential but a low clinical diagnosis rate. Therefore, we reported a case of PGA and reviewed the literature to summarize the clinicopathological features of pyloric adenoma. PATIENT CONCERNS: A 62-year-old female underwent gastroscopy due to intermittent acid regurgitation and heartburn, which revealed a 4×6 mm flat, elevated lesion in the greater curvature of the upper gastric body, with depression in the central region and blood scab attachment. DIAGNOSIS AND INTERVENTION: Biopsy revealed gastric adenoma with low-grade intraepithelial neoplasia. The patient was treated with ESD, and pathology showed gastric pyloric gland adenoma with low-grade dysplasia. The cells were positive for MUC6 and MUC5AC immunohistochemically. OUTCOMES: The patient received proton pump inhibitors and gastric mucosal protective agents for one month after ESD. She occasionally presented acid regurgitation and heartburn, with no abdominal pain, abdominal distension, melena, or hematochezia. Follow-up gastroscopy will be reexamined 1 year later. LESSONS: PGA has nonspecific performance under endoscopy, and its diagnosis mainly depends on pathology. Clinicians need to increase their ability to recognize such lesions and treat them in time to improve the prognosis.
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spelling pubmed-82383362021-07-06 Pyloric gland adenoma with low-grade intraepithelial neoplasia: A case report and literature review Li, Hai-Long Wang, Yan Ren, Yu-Bo Yang, Xue-Song Wang, Li Zhang, Lei Lin, Xiang-Chun Medicine (Baltimore) 4500 RATIONALE: Pyloric gland adenoma (PGA) is often associated with pyloric gland metaplasia. It has high malignant potential but a low clinical diagnosis rate. Therefore, we reported a case of PGA and reviewed the literature to summarize the clinicopathological features of pyloric adenoma. PATIENT CONCERNS: A 62-year-old female underwent gastroscopy due to intermittent acid regurgitation and heartburn, which revealed a 4×6 mm flat, elevated lesion in the greater curvature of the upper gastric body, with depression in the central region and blood scab attachment. DIAGNOSIS AND INTERVENTION: Biopsy revealed gastric adenoma with low-grade intraepithelial neoplasia. The patient was treated with ESD, and pathology showed gastric pyloric gland adenoma with low-grade dysplasia. The cells were positive for MUC6 and MUC5AC immunohistochemically. OUTCOMES: The patient received proton pump inhibitors and gastric mucosal protective agents for one month after ESD. She occasionally presented acid regurgitation and heartburn, with no abdominal pain, abdominal distension, melena, or hematochezia. Follow-up gastroscopy will be reexamined 1 year later. LESSONS: PGA has nonspecific performance under endoscopy, and its diagnosis mainly depends on pathology. Clinicians need to increase their ability to recognize such lesions and treat them in time to improve the prognosis. Lippincott Williams & Wilkins 2021-06-25 /pmc/articles/PMC8238336/ /pubmed/34160413 http://dx.doi.org/10.1097/MD.0000000000026378 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/)
spellingShingle 4500
Li, Hai-Long
Wang, Yan
Ren, Yu-Bo
Yang, Xue-Song
Wang, Li
Zhang, Lei
Lin, Xiang-Chun
Pyloric gland adenoma with low-grade intraepithelial neoplasia: A case report and literature review
title Pyloric gland adenoma with low-grade intraepithelial neoplasia: A case report and literature review
title_full Pyloric gland adenoma with low-grade intraepithelial neoplasia: A case report and literature review
title_fullStr Pyloric gland adenoma with low-grade intraepithelial neoplasia: A case report and literature review
title_full_unstemmed Pyloric gland adenoma with low-grade intraepithelial neoplasia: A case report and literature review
title_short Pyloric gland adenoma with low-grade intraepithelial neoplasia: A case report and literature review
title_sort pyloric gland adenoma with low-grade intraepithelial neoplasia: a case report and literature review
topic 4500
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238336/
https://www.ncbi.nlm.nih.gov/pubmed/34160413
http://dx.doi.org/10.1097/MD.0000000000026378
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