Cargando…

Diagnostic yields and clinical features of ocular myasthenia gravis

To investigate clinical features and diagnosis process of ocular myasthenia gravis (OMG) in ophthalmology department. A total of 36 patients with ptosis or diplopia who had follow-up for at least 3 months between March 2016 and December 2019 were included in this study. Clinical symptoms of patients...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Hyuna, Oh, Shin Yeop
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238339/
https://www.ncbi.nlm.nih.gov/pubmed/34160444
http://dx.doi.org/10.1097/MD.0000000000026457
_version_ 1783714885066031104
author Kim, Hyuna
Oh, Shin Yeop
author_facet Kim, Hyuna
Oh, Shin Yeop
author_sort Kim, Hyuna
collection PubMed
description To investigate clinical features and diagnosis process of ocular myasthenia gravis (OMG) in ophthalmology department. A total of 36 patients with ptosis or diplopia who had follow-up for at least 3 months between March 2016 and December 2019 were included in this study. Clinical symptoms of patients and the test results were analyzed. According to the positivity of serologic test, these patients were divided into 2 groups (confirmed OMG and possible OMG with relief of symptoms after antimyasthenic treatment) for comparison. Ptosis was present in 12 (33.33%) patients, diplopia was present in 14 (38.89%) patients, and both ptosis and diplopia were present in 10 (27.78%) patients. Acetylcholine receptor auto-antibody (AchR Ab) was positive in 14 (38.89%) of 36 patients and ice test was positive in 15 (71.43%) of 21 patients with ptosis. Unequivocal response to pyridostigmine was observed in 31 (86.11%) patients. For seropositive cases, AchR Ab titer was significantly higher in the group with 2 clinical symptoms than that in the 1 clinical symptom (P = .011). This study presents the usefulness and diagnostic validity of antimyasthenic treatment for OMG, especially seronegative OMG, with detailed symptom analysis.
format Online
Article
Text
id pubmed-8238339
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Lippincott Williams & Wilkins
record_format MEDLINE/PubMed
spelling pubmed-82383392021-07-06 Diagnostic yields and clinical features of ocular myasthenia gravis Kim, Hyuna Oh, Shin Yeop Medicine (Baltimore) 5800 To investigate clinical features and diagnosis process of ocular myasthenia gravis (OMG) in ophthalmology department. A total of 36 patients with ptosis or diplopia who had follow-up for at least 3 months between March 2016 and December 2019 were included in this study. Clinical symptoms of patients and the test results were analyzed. According to the positivity of serologic test, these patients were divided into 2 groups (confirmed OMG and possible OMG with relief of symptoms after antimyasthenic treatment) for comparison. Ptosis was present in 12 (33.33%) patients, diplopia was present in 14 (38.89%) patients, and both ptosis and diplopia were present in 10 (27.78%) patients. Acetylcholine receptor auto-antibody (AchR Ab) was positive in 14 (38.89%) of 36 patients and ice test was positive in 15 (71.43%) of 21 patients with ptosis. Unequivocal response to pyridostigmine was observed in 31 (86.11%) patients. For seropositive cases, AchR Ab titer was significantly higher in the group with 2 clinical symptoms than that in the 1 clinical symptom (P = .011). This study presents the usefulness and diagnostic validity of antimyasthenic treatment for OMG, especially seronegative OMG, with detailed symptom analysis. Lippincott Williams & Wilkins 2021-06-25 /pmc/articles/PMC8238339/ /pubmed/34160444 http://dx.doi.org/10.1097/MD.0000000000026457 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle 5800
Kim, Hyuna
Oh, Shin Yeop
Diagnostic yields and clinical features of ocular myasthenia gravis
title Diagnostic yields and clinical features of ocular myasthenia gravis
title_full Diagnostic yields and clinical features of ocular myasthenia gravis
title_fullStr Diagnostic yields and clinical features of ocular myasthenia gravis
title_full_unstemmed Diagnostic yields and clinical features of ocular myasthenia gravis
title_short Diagnostic yields and clinical features of ocular myasthenia gravis
title_sort diagnostic yields and clinical features of ocular myasthenia gravis
topic 5800
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238339/
https://www.ncbi.nlm.nih.gov/pubmed/34160444
http://dx.doi.org/10.1097/MD.0000000000026457
work_keys_str_mv AT kimhyuna diagnosticyieldsandclinicalfeaturesofocularmyastheniagravis
AT ohshinyeop diagnosticyieldsandclinicalfeaturesofocularmyastheniagravis