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Socioeconomic disparities in health: Changes in sleep quality and inflammation during bereavement

Widow(er)s experience significant sleep disruption that may dysregulate immune functioning. This longitudinal study aimed to determine 1) whether changes in sleep quality were associated with changes in pro-inflammatory cytokine production during the first six months of bereavement and 2) whether th...

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Autores principales: Wu, E. Lydia, Brown, Ryan L., Chirinos, Diana A., Chen, Michelle A., de Dios, Marcel A., Taylor, Daniela M., Butner, Jonathan E., Heijnen, Cobi J., Fagundes, Christopher P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238458/
https://www.ncbi.nlm.nih.gov/pubmed/34195688
http://dx.doi.org/10.1016/j.cpnec.2021.100056
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author Wu, E. Lydia
Brown, Ryan L.
Chirinos, Diana A.
Chen, Michelle A.
de Dios, Marcel A.
Taylor, Daniela M.
Butner, Jonathan E.
Heijnen, Cobi J.
Fagundes, Christopher P.
author_facet Wu, E. Lydia
Brown, Ryan L.
Chirinos, Diana A.
Chen, Michelle A.
de Dios, Marcel A.
Taylor, Daniela M.
Butner, Jonathan E.
Heijnen, Cobi J.
Fagundes, Christopher P.
author_sort Wu, E. Lydia
collection PubMed
description Widow(er)s experience significant sleep disruption that may dysregulate immune functioning. This longitudinal study aimed to determine 1) whether changes in sleep quality were associated with changes in pro-inflammatory cytokine production during the first six months of bereavement and 2) whether these relationships depended on objective socioeconomic status (SES) and/or subjective social status. One hundred and six bereaved spouses (M ​= ​68.49 years, SD ​= ​9.35, 69 females) completed the following assessments at approximately three months post-death and six-month post-death: a venous blood draw and self-report questionnaires on sleep quality (Pittsburgh Sleep Quality Index), SES (MacArthur Sociodemographic Questionnaire), health, and demographic information. T-cell stimulated pro-inflammatory cytokines were assessed, including IL-6, TNF-α, IFN-γ, IL-17A, and IL-2. Worsening sleep quality was associated with increased levels of pro-inflammatory activity even after adjusting for confounding variables. The present study also identified SES as an important factor for understanding health following spousal bereavement: individuals with low SES were more susceptible to sleep-related changes in immune function. Compared to more educated widow(er)s, less educated widow(er)s showed greater increases and decreases in inflammation when sleep quality worsened or improved, respectively, over time. Findings provide evidence for a biobehavioral pathway linking bereavement to disease risk, highlight SES disparities in late adulthood, and identify individuals who may require tailored interventions to offset SES-related burden that impedes adaptive grief recovery.
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spelling pubmed-82384582021-08-01 Socioeconomic disparities in health: Changes in sleep quality and inflammation during bereavement Wu, E. Lydia Brown, Ryan L. Chirinos, Diana A. Chen, Michelle A. de Dios, Marcel A. Taylor, Daniela M. Butner, Jonathan E. Heijnen, Cobi J. Fagundes, Christopher P. Compr Psychoneuroendocrinol Clinical Science Widow(er)s experience significant sleep disruption that may dysregulate immune functioning. This longitudinal study aimed to determine 1) whether changes in sleep quality were associated with changes in pro-inflammatory cytokine production during the first six months of bereavement and 2) whether these relationships depended on objective socioeconomic status (SES) and/or subjective social status. One hundred and six bereaved spouses (M ​= ​68.49 years, SD ​= ​9.35, 69 females) completed the following assessments at approximately three months post-death and six-month post-death: a venous blood draw and self-report questionnaires on sleep quality (Pittsburgh Sleep Quality Index), SES (MacArthur Sociodemographic Questionnaire), health, and demographic information. T-cell stimulated pro-inflammatory cytokines were assessed, including IL-6, TNF-α, IFN-γ, IL-17A, and IL-2. Worsening sleep quality was associated with increased levels of pro-inflammatory activity even after adjusting for confounding variables. The present study also identified SES as an important factor for understanding health following spousal bereavement: individuals with low SES were more susceptible to sleep-related changes in immune function. Compared to more educated widow(er)s, less educated widow(er)s showed greater increases and decreases in inflammation when sleep quality worsened or improved, respectively, over time. Findings provide evidence for a biobehavioral pathway linking bereavement to disease risk, highlight SES disparities in late adulthood, and identify individuals who may require tailored interventions to offset SES-related burden that impedes adaptive grief recovery. Elsevier 2021-04-22 /pmc/articles/PMC8238458/ /pubmed/34195688 http://dx.doi.org/10.1016/j.cpnec.2021.100056 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Clinical Science
Wu, E. Lydia
Brown, Ryan L.
Chirinos, Diana A.
Chen, Michelle A.
de Dios, Marcel A.
Taylor, Daniela M.
Butner, Jonathan E.
Heijnen, Cobi J.
Fagundes, Christopher P.
Socioeconomic disparities in health: Changes in sleep quality and inflammation during bereavement
title Socioeconomic disparities in health: Changes in sleep quality and inflammation during bereavement
title_full Socioeconomic disparities in health: Changes in sleep quality and inflammation during bereavement
title_fullStr Socioeconomic disparities in health: Changes in sleep quality and inflammation during bereavement
title_full_unstemmed Socioeconomic disparities in health: Changes in sleep quality and inflammation during bereavement
title_short Socioeconomic disparities in health: Changes in sleep quality and inflammation during bereavement
title_sort socioeconomic disparities in health: changes in sleep quality and inflammation during bereavement
topic Clinical Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238458/
https://www.ncbi.nlm.nih.gov/pubmed/34195688
http://dx.doi.org/10.1016/j.cpnec.2021.100056
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