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Spermidine Inhibits Joints Inflammation and Macrophage Activation in Mice with Collagen-Induced Arthritis

PURPOSE: Spermidine (SPD) is a naturally occurring polyamine. In this study, we examined the role and possible mechanism of SPD in collagen-induced arthritis (CIA) mice. MATERIALS AND METHODS: CIA mice were intraperitoneally injected with SPD (2 and 50 mg/kg), dexamethasone (0.5 mg/kg), or saline da...

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Detalles Bibliográficos
Autores principales:	Yuan, Hao, Wu, Si-Xian, Zhou, Yi-Feng, Peng, Fang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238551/ https://www.ncbi.nlm.nih.gov/pubmed/34194234 http://dx.doi.org/10.2147/JIR.S313179

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