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Genetic and Functional Evaluation of the Role of FOXO1 in Antituberculosis Drug-Induced Hepatotoxicity

BACKGROUND: The accumulation of the hepatotoxic substance protoporphyrin IX (PPIX) induced by aminolevulinate synthase 1 (ALAS1) activation is one of the important mechanisms of antituberculosis drug-induced hepatotoxicity (ATDH). Forkhead box protein O1 (FOXO1) may activate ALAS1 transcription. How...

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Detalles Bibliográficos
Autores principales:	Zhang, Jingwei, Jiao, Lin, Song, Jiajia, Wu, Tao, Bai, Hao, Liu, Tangyuheng, Zhao, Zhenzhen, Hu, Xuejiao, Ying, Binwu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238576/ https://www.ncbi.nlm.nih.gov/pubmed/34249128 http://dx.doi.org/10.1155/2021/3185874

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