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Fel d1 Blocking Antibodies: A Novel Method to Reduce IgE-Mediated Allergy to Cats
Fel d1 is an important allergen produced by cats that causes IgE reactions in up to 95% of cat-allergic adults. Immunotherapy to reduce human allergy to cats has demonstrated that people have the capacity to produce allergen-specific neutralizing antibodies that block IgE-mediated allergic responses...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238577/ https://www.ncbi.nlm.nih.gov/pubmed/34250096 http://dx.doi.org/10.1155/2021/5545173 |
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author | Satyaraj, Ebenezer Sun, Peichuan Sherrill, Scott |
author_facet | Satyaraj, Ebenezer Sun, Peichuan Sherrill, Scott |
author_sort | Satyaraj, Ebenezer |
collection | PubMed |
description | Fel d1 is an important allergen produced by cats that causes IgE reactions in up to 95% of cat-allergic adults. Immunotherapy to reduce human allergy to cats has demonstrated that people have the capacity to produce allergen-specific neutralizing antibodies that block IgE-mediated allergic responses. We wished to determine if “blocking” antibodies could be used to reduce the IgE binding ability of cat allergens prior to their exposure to humans. Here, we describe the characterization of Fel d1-specific antibodies. We demonstrated the efficacy of a rabbit polyclonal and an allergen-specific chicken IgY to bind to Fel d1 in cat saliva and block Fel d1-IgE binding and IgE-mediated basophil degranulation. Fel d1 blocking antibodies offer a new and exciting approach to the neutralization of cat allergens. |
format | Online Article Text |
id | pubmed-8238577 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-82385772021-07-08 Fel d1 Blocking Antibodies: A Novel Method to Reduce IgE-Mediated Allergy to Cats Satyaraj, Ebenezer Sun, Peichuan Sherrill, Scott J Immunol Res Research Article Fel d1 is an important allergen produced by cats that causes IgE reactions in up to 95% of cat-allergic adults. Immunotherapy to reduce human allergy to cats has demonstrated that people have the capacity to produce allergen-specific neutralizing antibodies that block IgE-mediated allergic responses. We wished to determine if “blocking” antibodies could be used to reduce the IgE binding ability of cat allergens prior to their exposure to humans. Here, we describe the characterization of Fel d1-specific antibodies. We demonstrated the efficacy of a rabbit polyclonal and an allergen-specific chicken IgY to bind to Fel d1 in cat saliva and block Fel d1-IgE binding and IgE-mediated basophil degranulation. Fel d1 blocking antibodies offer a new and exciting approach to the neutralization of cat allergens. Hindawi 2021-06-19 /pmc/articles/PMC8238577/ /pubmed/34250096 http://dx.doi.org/10.1155/2021/5545173 Text en Copyright © 2021 Ebenezer Satyaraj et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Satyaraj, Ebenezer Sun, Peichuan Sherrill, Scott Fel d1 Blocking Antibodies: A Novel Method to Reduce IgE-Mediated Allergy to Cats |
title | Fel d1 Blocking Antibodies: A Novel Method to Reduce IgE-Mediated Allergy to Cats |
title_full | Fel d1 Blocking Antibodies: A Novel Method to Reduce IgE-Mediated Allergy to Cats |
title_fullStr | Fel d1 Blocking Antibodies: A Novel Method to Reduce IgE-Mediated Allergy to Cats |
title_full_unstemmed | Fel d1 Blocking Antibodies: A Novel Method to Reduce IgE-Mediated Allergy to Cats |
title_short | Fel d1 Blocking Antibodies: A Novel Method to Reduce IgE-Mediated Allergy to Cats |
title_sort | fel d1 blocking antibodies: a novel method to reduce ige-mediated allergy to cats |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238577/ https://www.ncbi.nlm.nih.gov/pubmed/34250096 http://dx.doi.org/10.1155/2021/5545173 |
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