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The Epidemiology of Primary Biliary Cholangitis in European Countries: A Systematic Review and Meta-Analysis

BACKGROUND: Primary biliary cholangitis (PBC) is a chronic autoimmune cholestatic liver disease with wide ranges of reported incidence and prevalence. AIM: To map the incidence and prevalence of PBC in European countries from 2000 through 2020. METHODS: Following PRISMA recommendations, we searched...

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Detalles Bibliográficos
Autores principales: Gazda, Jakub, Drazilova, Sylvia, Janicko, Martin, Jarcuska, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238597/
https://www.ncbi.nlm.nih.gov/pubmed/34239845
http://dx.doi.org/10.1155/2021/9151525
Descripción
Sumario:BACKGROUND: Primary biliary cholangitis (PBC) is a chronic autoimmune cholestatic liver disease with wide ranges of reported incidence and prevalence. AIM: To map the incidence and prevalence of PBC in European countries from 2000 through 2020. METHODS: Following PRISMA recommendations, we searched the Medline and Scopus databases for studies with information on either the incidence or prevalence of PBC. After data extraction, we used a random-effects model to estimate both the pooled annual incidence rate and pooled point-prevalence rate and performed subgroup analyses to identify components contributing to between-study heterogeneity. RESULTS: We performed a qualitative and quantitative analysis of 18 studies. The pooled point-prevalence rate was 22.27 cases per 100,000 inhabitants (95% CI: 17.98–27.01), and the pooled annual incidence rate was 1.87 new cases per 100,000 inhabitants (95% CI: 1.46–2.34). In the subgroup analyses, we proved that a small part of the between-study heterogeneity is significantly associated with a history of being part of the Eastern Bloc.