Animal models of SARS-CoV-2 transmission

SARS-CoV-2 emerged in China as a zoonotic virus in December 2019. The virus proved to be human-to-human transmissible and its global spread resulted in the ongoing COVID-19 pandemic, associated with high morbidity and mortality. Vaccines were developed at an unprecedented speed and proved to be effi...

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Autores principales: de Vries, Rory D, Rockx, Barry, Haagmans, Bart L, Herfst, Sander, Koopmans, Marion PG, de Swart, Rik L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier B.V. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238653/
https://www.ncbi.nlm.nih.gov/pubmed/34256352
http://dx.doi.org/10.1016/j.coviro.2021.06.007
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author de Vries, Rory D
Rockx, Barry
Haagmans, Bart L
Herfst, Sander
Koopmans, Marion PG
de Swart, Rik L
author_facet de Vries, Rory D
Rockx, Barry
Haagmans, Bart L
Herfst, Sander
Koopmans, Marion PG
de Swart, Rik L
author_sort de Vries, Rory D
collection PubMed
description SARS-CoV-2 emerged in China as a zoonotic virus in December 2019. The virus proved to be human-to-human transmissible and its global spread resulted in the ongoing COVID-19 pandemic, associated with high morbidity and mortality. Vaccines were developed at an unprecedented speed and proved to be efficacious in preventing disease, but it remains to be determined if vaccines are able to interrupt transmission. Moreover, virus variants of concern continue to emerge that appear more transmissible and/or less sensitive to virus-specific immune responses. Here, we briefly review the role of animal models in assessing prophylactic and therapeutic options to interrupt SARS-CoV-2 transmission.
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spelling pubmed-82386532021-06-29 Animal models of SARS-CoV-2 transmission de Vries, Rory D Rockx, Barry Haagmans, Bart L Herfst, Sander Koopmans, Marion PG de Swart, Rik L Curr Opin Virol Article SARS-CoV-2 emerged in China as a zoonotic virus in December 2019. The virus proved to be human-to-human transmissible and its global spread resulted in the ongoing COVID-19 pandemic, associated with high morbidity and mortality. Vaccines were developed at an unprecedented speed and proved to be efficacious in preventing disease, but it remains to be determined if vaccines are able to interrupt transmission. Moreover, virus variants of concern continue to emerge that appear more transmissible and/or less sensitive to virus-specific immune responses. Here, we briefly review the role of animal models in assessing prophylactic and therapeutic options to interrupt SARS-CoV-2 transmission. The Author(s). Published by Elsevier B.V. 2021-10 2021-06-29 /pmc/articles/PMC8238653/ /pubmed/34256352 http://dx.doi.org/10.1016/j.coviro.2021.06.007 Text en © 2021 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
de Vries, Rory D
Rockx, Barry
Haagmans, Bart L
Herfst, Sander
Koopmans, Marion PG
de Swart, Rik L
Animal models of SARS-CoV-2 transmission
title Animal models of SARS-CoV-2 transmission
title_full Animal models of SARS-CoV-2 transmission
title_fullStr Animal models of SARS-CoV-2 transmission
title_full_unstemmed Animal models of SARS-CoV-2 transmission
title_short Animal models of SARS-CoV-2 transmission
title_sort animal models of sars-cov-2 transmission
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238653/
https://www.ncbi.nlm.nih.gov/pubmed/34256352
http://dx.doi.org/10.1016/j.coviro.2021.06.007
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