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A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids
Here we examine the association between DNA methylation in circulating leukocytes and blood lipids in a multi-ethnic sample of 16,265 subjects. We identify 148, 35, and 4 novel associations among Europeans, African Americans, and Hispanics, respectively, and an additional 186 novel associations thro...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238961/ https://www.ncbi.nlm.nih.gov/pubmed/34183656 http://dx.doi.org/10.1038/s41467-021-23899-y |
| _version_ | 1783714984816017408 |
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| author | Jhun, Min-A Mendelson, Michael Wilson, Rory Gondalia, Rahul Joehanes, Roby Salfati, Elias Zhao, Xiaoping Braun, Kim Valeska Emilie Do, Anh Nguyet Hedman, Åsa K. Zhang, Tao Carnero-Montoro, Elena Shen, Jincheng Bartz, Traci M. Brody, Jennifer A. Montasser, May E. O’Connell, Jeff R. Yao, Chen Xia, Rui Boerwinkle, Eric Grove, Megan Guan, Weihua Liliane, Pfeiffer Singmann, Paula Müller-Nurasyid, Martina Meitinger, Thomas Gieger, Christian Peters, Annette Zhao, Wei Ware, Erin B. Smith, Jennifer A. Dhana, Klodian van Meurs, Joyce Uitterlinden, Andre Ikram, Mohammad Arfan Ghanbari, Mohsen Zhi, Deugi Gustafsson, Stefan Lind, Lars Li, Shengxu Sun, Dianjianyi Spector, Tim D. Chen, Yii-der Ida Damcott, Coleen Shuldiner, Alan R. Absher, Devin M. Horvath, Steve Tsao, Philip S. Kardia, Sharon Psaty, Bruce M. Sotoodehnia, Nona Bell, Jordana T. Ingelsson, Erik Chen, Wei Dehghan, Abbas Arnett, Donna K. Waldenberger, Melanie Hou, Lifang Whitsel, Eric A. Baccarelli, Andrea Levy, Daniel Fornage, Myriam Irvin, Marguerite R. Assimes, Themistocles L. |
| author_facet | Jhun, Min-A Mendelson, Michael Wilson, Rory Gondalia, Rahul Joehanes, Roby Salfati, Elias Zhao, Xiaoping Braun, Kim Valeska Emilie Do, Anh Nguyet Hedman, Åsa K. Zhang, Tao Carnero-Montoro, Elena Shen, Jincheng Bartz, Traci M. Brody, Jennifer A. Montasser, May E. O’Connell, Jeff R. Yao, Chen Xia, Rui Boerwinkle, Eric Grove, Megan Guan, Weihua Liliane, Pfeiffer Singmann, Paula Müller-Nurasyid, Martina Meitinger, Thomas Gieger, Christian Peters, Annette Zhao, Wei Ware, Erin B. Smith, Jennifer A. Dhana, Klodian van Meurs, Joyce Uitterlinden, Andre Ikram, Mohammad Arfan Ghanbari, Mohsen Zhi, Deugi Gustafsson, Stefan Lind, Lars Li, Shengxu Sun, Dianjianyi Spector, Tim D. Chen, Yii-der Ida Damcott, Coleen Shuldiner, Alan R. Absher, Devin M. Horvath, Steve Tsao, Philip S. Kardia, Sharon Psaty, Bruce M. Sotoodehnia, Nona Bell, Jordana T. Ingelsson, Erik Chen, Wei Dehghan, Abbas Arnett, Donna K. Waldenberger, Melanie Hou, Lifang Whitsel, Eric A. Baccarelli, Andrea Levy, Daniel Fornage, Myriam Irvin, Marguerite R. Assimes, Themistocles L. |
| author_sort | Jhun, Min-A |
| collection | PubMed |
| description | Here we examine the association between DNA methylation in circulating leukocytes and blood lipids in a multi-ethnic sample of 16,265 subjects. We identify 148, 35, and 4 novel associations among Europeans, African Americans, and Hispanics, respectively, and an additional 186 novel associations through a trans-ethnic meta-analysis. We observe a high concordance in the direction of effects across racial/ethnic groups, a high correlation of effect sizes between high-density lipoprotein and triglycerides, a modest overlap of associations with epigenome-wide association studies of other cardio-metabolic traits, and a largely non-overlap with lipid loci identified to date through genome-wide association studies. Thirty CpGs reached significance in at least 2 racial/ethnic groups including 7 that showed association with the expression of an annotated gene. CpGs annotated to CPT1A showed evidence of being influenced by triglycerides levels. DNA methylation levels of circulating leukocytes show robust and consistent association with blood lipid levels across multiple racial/ethnic groups. |
| format | Online Article Text |
| id | pubmed-8238961 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-82389612021-07-23 A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids Jhun, Min-A Mendelson, Michael Wilson, Rory Gondalia, Rahul Joehanes, Roby Salfati, Elias Zhao, Xiaoping Braun, Kim Valeska Emilie Do, Anh Nguyet Hedman, Åsa K. Zhang, Tao Carnero-Montoro, Elena Shen, Jincheng Bartz, Traci M. Brody, Jennifer A. Montasser, May E. O’Connell, Jeff R. Yao, Chen Xia, Rui Boerwinkle, Eric Grove, Megan Guan, Weihua Liliane, Pfeiffer Singmann, Paula Müller-Nurasyid, Martina Meitinger, Thomas Gieger, Christian Peters, Annette Zhao, Wei Ware, Erin B. Smith, Jennifer A. Dhana, Klodian van Meurs, Joyce Uitterlinden, Andre Ikram, Mohammad Arfan Ghanbari, Mohsen Zhi, Deugi Gustafsson, Stefan Lind, Lars Li, Shengxu Sun, Dianjianyi Spector, Tim D. Chen, Yii-der Ida Damcott, Coleen Shuldiner, Alan R. Absher, Devin M. Horvath, Steve Tsao, Philip S. Kardia, Sharon Psaty, Bruce M. Sotoodehnia, Nona Bell, Jordana T. Ingelsson, Erik Chen, Wei Dehghan, Abbas Arnett, Donna K. Waldenberger, Melanie Hou, Lifang Whitsel, Eric A. Baccarelli, Andrea Levy, Daniel Fornage, Myriam Irvin, Marguerite R. Assimes, Themistocles L. Nat Commun Article Here we examine the association between DNA methylation in circulating leukocytes and blood lipids in a multi-ethnic sample of 16,265 subjects. We identify 148, 35, and 4 novel associations among Europeans, African Americans, and Hispanics, respectively, and an additional 186 novel associations through a trans-ethnic meta-analysis. We observe a high concordance in the direction of effects across racial/ethnic groups, a high correlation of effect sizes between high-density lipoprotein and triglycerides, a modest overlap of associations with epigenome-wide association studies of other cardio-metabolic traits, and a largely non-overlap with lipid loci identified to date through genome-wide association studies. Thirty CpGs reached significance in at least 2 racial/ethnic groups including 7 that showed association with the expression of an annotated gene. CpGs annotated to CPT1A showed evidence of being influenced by triglycerides levels. DNA methylation levels of circulating leukocytes show robust and consistent association with blood lipid levels across multiple racial/ethnic groups. Nature Publishing Group UK 2021-06-28 /pmc/articles/PMC8238961/ /pubmed/34183656 http://dx.doi.org/10.1038/s41467-021-23899-y Text en © This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2021, corrected publication 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Article Jhun, Min-A Mendelson, Michael Wilson, Rory Gondalia, Rahul Joehanes, Roby Salfati, Elias Zhao, Xiaoping Braun, Kim Valeska Emilie Do, Anh Nguyet Hedman, Åsa K. Zhang, Tao Carnero-Montoro, Elena Shen, Jincheng Bartz, Traci M. Brody, Jennifer A. Montasser, May E. O’Connell, Jeff R. Yao, Chen Xia, Rui Boerwinkle, Eric Grove, Megan Guan, Weihua Liliane, Pfeiffer Singmann, Paula Müller-Nurasyid, Martina Meitinger, Thomas Gieger, Christian Peters, Annette Zhao, Wei Ware, Erin B. Smith, Jennifer A. Dhana, Klodian van Meurs, Joyce Uitterlinden, Andre Ikram, Mohammad Arfan Ghanbari, Mohsen Zhi, Deugi Gustafsson, Stefan Lind, Lars Li, Shengxu Sun, Dianjianyi Spector, Tim D. Chen, Yii-der Ida Damcott, Coleen Shuldiner, Alan R. Absher, Devin M. Horvath, Steve Tsao, Philip S. Kardia, Sharon Psaty, Bruce M. Sotoodehnia, Nona Bell, Jordana T. Ingelsson, Erik Chen, Wei Dehghan, Abbas Arnett, Donna K. Waldenberger, Melanie Hou, Lifang Whitsel, Eric A. Baccarelli, Andrea Levy, Daniel Fornage, Myriam Irvin, Marguerite R. Assimes, Themistocles L. A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids |
| title | A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids |
| title_full | A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids |
| title_fullStr | A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids |
| title_full_unstemmed | A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids |
| title_short | A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids |
| title_sort | multi-ethnic epigenome-wide association study of leukocyte dna methylation and blood lipids |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238961/ https://www.ncbi.nlm.nih.gov/pubmed/34183656 http://dx.doi.org/10.1038/s41467-021-23899-y |
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