Cargando…
Efficient long-range conduction in cable bacteria through nickel protein wires
Filamentous cable bacteria display long-range electron transport, generating electrical currents over centimeter distances through a highly ordered network of fibers embedded in their cell envelope. The conductivity of these periplasmic wires is exceptionally high for a biological material, but thei...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238962/ https://www.ncbi.nlm.nih.gov/pubmed/34183682 http://dx.doi.org/10.1038/s41467-021-24312-4 |
_version_ | 1783714985051947008 |
---|---|
author | Boschker, Henricus T. S. Cook, Perran L. M. Polerecky, Lubos Eachambadi, Raghavendran Thiruvallur Lozano, Helena Hidalgo-Martinez, Silvia Khalenkow, Dmitry Spampinato, Valentina Claes, Nathalie Kundu, Paromita Wang, Da Bals, Sara Sand, Karina K. Cavezza, Francesca Hauffman, Tom Bjerg, Jesper Tataru Skirtach, Andre G. Kochan, Kamila McKee, Merrilyn Wood, Bayden Bedolla, Diana Gianoncelli, Alessandra Geerlings, Nicole M. J. Van Gerven, Nani Remaut, Han Geelhoed, Jeanine S. Millan-Solsona, Ruben Fumagalli, Laura Nielsen, Lars Peter Franquet, Alexis Manca, Jean V. Gomila, Gabriel Meysman, Filip J. R. |
author_facet | Boschker, Henricus T. S. Cook, Perran L. M. Polerecky, Lubos Eachambadi, Raghavendran Thiruvallur Lozano, Helena Hidalgo-Martinez, Silvia Khalenkow, Dmitry Spampinato, Valentina Claes, Nathalie Kundu, Paromita Wang, Da Bals, Sara Sand, Karina K. Cavezza, Francesca Hauffman, Tom Bjerg, Jesper Tataru Skirtach, Andre G. Kochan, Kamila McKee, Merrilyn Wood, Bayden Bedolla, Diana Gianoncelli, Alessandra Geerlings, Nicole M. J. Van Gerven, Nani Remaut, Han Geelhoed, Jeanine S. Millan-Solsona, Ruben Fumagalli, Laura Nielsen, Lars Peter Franquet, Alexis Manca, Jean V. Gomila, Gabriel Meysman, Filip J. R. |
author_sort | Boschker, Henricus T. S. |
collection | PubMed |
description | Filamentous cable bacteria display long-range electron transport, generating electrical currents over centimeter distances through a highly ordered network of fibers embedded in their cell envelope. The conductivity of these periplasmic wires is exceptionally high for a biological material, but their chemical structure and underlying electron transport mechanism remain unresolved. Here, we combine high-resolution microscopy, spectroscopy, and chemical imaging on individual cable bacterium filaments to demonstrate that the periplasmic wires consist of a conductive protein core surrounded by an insulating protein shell layer. The core proteins contain a sulfur-ligated nickel cofactor, and conductivity decreases when nickel is oxidized or selectively removed. The involvement of nickel as the active metal in biological conduction is remarkable, and suggests a hitherto unknown form of electron transport that enables efficient conduction in centimeter-long protein structures. |
format | Online Article Text |
id | pubmed-8238962 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-82389622021-07-20 Efficient long-range conduction in cable bacteria through nickel protein wires Boschker, Henricus T. S. Cook, Perran L. M. Polerecky, Lubos Eachambadi, Raghavendran Thiruvallur Lozano, Helena Hidalgo-Martinez, Silvia Khalenkow, Dmitry Spampinato, Valentina Claes, Nathalie Kundu, Paromita Wang, Da Bals, Sara Sand, Karina K. Cavezza, Francesca Hauffman, Tom Bjerg, Jesper Tataru Skirtach, Andre G. Kochan, Kamila McKee, Merrilyn Wood, Bayden Bedolla, Diana Gianoncelli, Alessandra Geerlings, Nicole M. J. Van Gerven, Nani Remaut, Han Geelhoed, Jeanine S. Millan-Solsona, Ruben Fumagalli, Laura Nielsen, Lars Peter Franquet, Alexis Manca, Jean V. Gomila, Gabriel Meysman, Filip J. R. Nat Commun Article Filamentous cable bacteria display long-range electron transport, generating electrical currents over centimeter distances through a highly ordered network of fibers embedded in their cell envelope. The conductivity of these periplasmic wires is exceptionally high for a biological material, but their chemical structure and underlying electron transport mechanism remain unresolved. Here, we combine high-resolution microscopy, spectroscopy, and chemical imaging on individual cable bacterium filaments to demonstrate that the periplasmic wires consist of a conductive protein core surrounded by an insulating protein shell layer. The core proteins contain a sulfur-ligated nickel cofactor, and conductivity decreases when nickel is oxidized or selectively removed. The involvement of nickel as the active metal in biological conduction is remarkable, and suggests a hitherto unknown form of electron transport that enables efficient conduction in centimeter-long protein structures. Nature Publishing Group UK 2021-06-28 /pmc/articles/PMC8238962/ /pubmed/34183682 http://dx.doi.org/10.1038/s41467-021-24312-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Boschker, Henricus T. S. Cook, Perran L. M. Polerecky, Lubos Eachambadi, Raghavendran Thiruvallur Lozano, Helena Hidalgo-Martinez, Silvia Khalenkow, Dmitry Spampinato, Valentina Claes, Nathalie Kundu, Paromita Wang, Da Bals, Sara Sand, Karina K. Cavezza, Francesca Hauffman, Tom Bjerg, Jesper Tataru Skirtach, Andre G. Kochan, Kamila McKee, Merrilyn Wood, Bayden Bedolla, Diana Gianoncelli, Alessandra Geerlings, Nicole M. J. Van Gerven, Nani Remaut, Han Geelhoed, Jeanine S. Millan-Solsona, Ruben Fumagalli, Laura Nielsen, Lars Peter Franquet, Alexis Manca, Jean V. Gomila, Gabriel Meysman, Filip J. R. Efficient long-range conduction in cable bacteria through nickel protein wires |
title | Efficient long-range conduction in cable bacteria through nickel protein wires |
title_full | Efficient long-range conduction in cable bacteria through nickel protein wires |
title_fullStr | Efficient long-range conduction in cable bacteria through nickel protein wires |
title_full_unstemmed | Efficient long-range conduction in cable bacteria through nickel protein wires |
title_short | Efficient long-range conduction in cable bacteria through nickel protein wires |
title_sort | efficient long-range conduction in cable bacteria through nickel protein wires |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238962/ https://www.ncbi.nlm.nih.gov/pubmed/34183682 http://dx.doi.org/10.1038/s41467-021-24312-4 |
work_keys_str_mv | AT boschkerhenricusts efficientlongrangeconductionincablebacteriathroughnickelproteinwires AT cookperranlm efficientlongrangeconductionincablebacteriathroughnickelproteinwires AT polereckylubos efficientlongrangeconductionincablebacteriathroughnickelproteinwires AT eachambadiraghavendranthiruvallur efficientlongrangeconductionincablebacteriathroughnickelproteinwires AT lozanohelena efficientlongrangeconductionincablebacteriathroughnickelproteinwires AT hidalgomartinezsilvia efficientlongrangeconductionincablebacteriathroughnickelproteinwires AT khalenkowdmitry efficientlongrangeconductionincablebacteriathroughnickelproteinwires AT spampinatovalentina efficientlongrangeconductionincablebacteriathroughnickelproteinwires AT claesnathalie efficientlongrangeconductionincablebacteriathroughnickelproteinwires AT kunduparomita efficientlongrangeconductionincablebacteriathroughnickelproteinwires AT wangda efficientlongrangeconductionincablebacteriathroughnickelproteinwires AT balssara efficientlongrangeconductionincablebacteriathroughnickelproteinwires AT sandkarinak efficientlongrangeconductionincablebacteriathroughnickelproteinwires AT cavezzafrancesca efficientlongrangeconductionincablebacteriathroughnickelproteinwires AT hauffmantom efficientlongrangeconductionincablebacteriathroughnickelproteinwires AT bjergjespertataru efficientlongrangeconductionincablebacteriathroughnickelproteinwires AT skirtachandreg efficientlongrangeconductionincablebacteriathroughnickelproteinwires AT kochankamila efficientlongrangeconductionincablebacteriathroughnickelproteinwires AT mckeemerrilyn efficientlongrangeconductionincablebacteriathroughnickelproteinwires AT woodbayden efficientlongrangeconductionincablebacteriathroughnickelproteinwires AT bedolladiana efficientlongrangeconductionincablebacteriathroughnickelproteinwires AT gianoncellialessandra efficientlongrangeconductionincablebacteriathroughnickelproteinwires AT geerlingsnicolemj efficientlongrangeconductionincablebacteriathroughnickelproteinwires AT vangervennani efficientlongrangeconductionincablebacteriathroughnickelproteinwires AT remauthan efficientlongrangeconductionincablebacteriathroughnickelproteinwires AT geelhoedjeanines efficientlongrangeconductionincablebacteriathroughnickelproteinwires AT millansolsonaruben efficientlongrangeconductionincablebacteriathroughnickelproteinwires AT fumagallilaura efficientlongrangeconductionincablebacteriathroughnickelproteinwires AT nielsenlarspeter efficientlongrangeconductionincablebacteriathroughnickelproteinwires AT franquetalexis efficientlongrangeconductionincablebacteriathroughnickelproteinwires AT mancajeanv efficientlongrangeconductionincablebacteriathroughnickelproteinwires AT gomilagabriel efficientlongrangeconductionincablebacteriathroughnickelproteinwires AT meysmanfilipjr efficientlongrangeconductionincablebacteriathroughnickelproteinwires |