Cargando…
Assessing the impact of aging and blood pressure on dermal microvasculature by reactive hyperemia optical coherence tomography angiography
Visualization and quantification of the skin microvasculature are important for studying the health of the human microcirculation. We correlated structural and pathophysiological changes of the dermal capillary-level microvasculature with age and blood pressure by using the reactive hyperemia optica...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238964/ https://www.ncbi.nlm.nih.gov/pubmed/34183707 http://dx.doi.org/10.1038/s41598-021-92712-z |
_version_ | 1783714985515417600 |
---|---|
author | Wang-Evers, Michael Casper, Malte J. Glahn, Joshua Luo, Tuanlian Doyle, Abigail E. Karasik, Daniel Kim, Anne C. Phothong, Weeranut Nathan, Neera R. Heesakker, Tammy Kositratna, Garuna Manstein, Dieter |
author_facet | Wang-Evers, Michael Casper, Malte J. Glahn, Joshua Luo, Tuanlian Doyle, Abigail E. Karasik, Daniel Kim, Anne C. Phothong, Weeranut Nathan, Neera R. Heesakker, Tammy Kositratna, Garuna Manstein, Dieter |
author_sort | Wang-Evers, Michael |
collection | PubMed |
description | Visualization and quantification of the skin microvasculature are important for studying the health of the human microcirculation. We correlated structural and pathophysiological changes of the dermal capillary-level microvasculature with age and blood pressure by using the reactive hyperemia optical coherence tomography angiography (RH-OCT-A) technique and evaluated both conventional OCT-A and the RH-OCT-A method as non-invasive imaging alternatives to histopathology. This observational pilot study acquired OCT-A and RH-OCT-A images of the dermal microvasculature of 13 young and 12 old healthy Caucasian female subjects. Two skin biopsies were collected per subject for histological analysis. The dermal microvasculature in OCT-A, RH-OCT-A, and histological images were automatically quantified and significant indications of vessel rarefaction in both old subjects and subjects with high blood pressure were observed by RH-OCT-A and histopathology. We showed that an increase in dermal microvasculature perfusion in response to reactive hyperemia was significantly lower in high blood pressure subjects compared to normal blood pressure subjects (117% vs. 229%). These results demonstrate that RH-OCT-A imaging holds functional information of the microvasculature with respect to physiological factors such as age and blood pressure that may help to monitor early disease progression and assess overall vascular health. Additionally, our results suggest that RH-OCT-A images may serve as a non-invasive alternative to histopathology for vascular analysis. |
format | Online Article Text |
id | pubmed-8238964 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-82389642021-07-06 Assessing the impact of aging and blood pressure on dermal microvasculature by reactive hyperemia optical coherence tomography angiography Wang-Evers, Michael Casper, Malte J. Glahn, Joshua Luo, Tuanlian Doyle, Abigail E. Karasik, Daniel Kim, Anne C. Phothong, Weeranut Nathan, Neera R. Heesakker, Tammy Kositratna, Garuna Manstein, Dieter Sci Rep Article Visualization and quantification of the skin microvasculature are important for studying the health of the human microcirculation. We correlated structural and pathophysiological changes of the dermal capillary-level microvasculature with age and blood pressure by using the reactive hyperemia optical coherence tomography angiography (RH-OCT-A) technique and evaluated both conventional OCT-A and the RH-OCT-A method as non-invasive imaging alternatives to histopathology. This observational pilot study acquired OCT-A and RH-OCT-A images of the dermal microvasculature of 13 young and 12 old healthy Caucasian female subjects. Two skin biopsies were collected per subject for histological analysis. The dermal microvasculature in OCT-A, RH-OCT-A, and histological images were automatically quantified and significant indications of vessel rarefaction in both old subjects and subjects with high blood pressure were observed by RH-OCT-A and histopathology. We showed that an increase in dermal microvasculature perfusion in response to reactive hyperemia was significantly lower in high blood pressure subjects compared to normal blood pressure subjects (117% vs. 229%). These results demonstrate that RH-OCT-A imaging holds functional information of the microvasculature with respect to physiological factors such as age and blood pressure that may help to monitor early disease progression and assess overall vascular health. Additionally, our results suggest that RH-OCT-A images may serve as a non-invasive alternative to histopathology for vascular analysis. Nature Publishing Group UK 2021-06-28 /pmc/articles/PMC8238964/ /pubmed/34183707 http://dx.doi.org/10.1038/s41598-021-92712-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Wang-Evers, Michael Casper, Malte J. Glahn, Joshua Luo, Tuanlian Doyle, Abigail E. Karasik, Daniel Kim, Anne C. Phothong, Weeranut Nathan, Neera R. Heesakker, Tammy Kositratna, Garuna Manstein, Dieter Assessing the impact of aging and blood pressure on dermal microvasculature by reactive hyperemia optical coherence tomography angiography |
title | Assessing the impact of aging and blood pressure on dermal microvasculature by reactive hyperemia optical coherence tomography angiography |
title_full | Assessing the impact of aging and blood pressure on dermal microvasculature by reactive hyperemia optical coherence tomography angiography |
title_fullStr | Assessing the impact of aging and blood pressure on dermal microvasculature by reactive hyperemia optical coherence tomography angiography |
title_full_unstemmed | Assessing the impact of aging and blood pressure on dermal microvasculature by reactive hyperemia optical coherence tomography angiography |
title_short | Assessing the impact of aging and blood pressure on dermal microvasculature by reactive hyperemia optical coherence tomography angiography |
title_sort | assessing the impact of aging and blood pressure on dermal microvasculature by reactive hyperemia optical coherence tomography angiography |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238964/ https://www.ncbi.nlm.nih.gov/pubmed/34183707 http://dx.doi.org/10.1038/s41598-021-92712-z |
work_keys_str_mv | AT wangeversmichael assessingtheimpactofagingandbloodpressureondermalmicrovasculaturebyreactivehyperemiaopticalcoherencetomographyangiography AT caspermaltej assessingtheimpactofagingandbloodpressureondermalmicrovasculaturebyreactivehyperemiaopticalcoherencetomographyangiography AT glahnjoshua assessingtheimpactofagingandbloodpressureondermalmicrovasculaturebyreactivehyperemiaopticalcoherencetomographyangiography AT luotuanlian assessingtheimpactofagingandbloodpressureondermalmicrovasculaturebyreactivehyperemiaopticalcoherencetomographyangiography AT doyleabigaile assessingtheimpactofagingandbloodpressureondermalmicrovasculaturebyreactivehyperemiaopticalcoherencetomographyangiography AT karasikdaniel assessingtheimpactofagingandbloodpressureondermalmicrovasculaturebyreactivehyperemiaopticalcoherencetomographyangiography AT kimannec assessingtheimpactofagingandbloodpressureondermalmicrovasculaturebyreactivehyperemiaopticalcoherencetomographyangiography AT phothongweeranut assessingtheimpactofagingandbloodpressureondermalmicrovasculaturebyreactivehyperemiaopticalcoherencetomographyangiography AT nathanneerar assessingtheimpactofagingandbloodpressureondermalmicrovasculaturebyreactivehyperemiaopticalcoherencetomographyangiography AT heesakkertammy assessingtheimpactofagingandbloodpressureondermalmicrovasculaturebyreactivehyperemiaopticalcoherencetomographyangiography AT kositratnagaruna assessingtheimpactofagingandbloodpressureondermalmicrovasculaturebyreactivehyperemiaopticalcoherencetomographyangiography AT mansteindieter assessingtheimpactofagingandbloodpressureondermalmicrovasculaturebyreactivehyperemiaopticalcoherencetomographyangiography |