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Higher CSF sTNFR1-related proteins associate with better prognosis in very early Alzheimer’s disease
Neuroinflammation is associated with Alzheimer’s disease, but the application of cerebrospinal fluid measures of inflammatory proteins may be limited by overlapping pathways and relationships between them. In this work, we measure 15 cerebrospinal proteins related to microglial and T-cell functions,...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238986/ https://www.ncbi.nlm.nih.gov/pubmed/34183654 http://dx.doi.org/10.1038/s41467-021-24220-7 |
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author | Hu, William T. Ozturk, Tugba Kollhoff, Alexander Wharton, Whitney Christina Howell, J. |
author_facet | Hu, William T. Ozturk, Tugba Kollhoff, Alexander Wharton, Whitney Christina Howell, J. |
author_sort | Hu, William T. |
collection | PubMed |
description | Neuroinflammation is associated with Alzheimer’s disease, but the application of cerebrospinal fluid measures of inflammatory proteins may be limited by overlapping pathways and relationships between them. In this work, we measure 15 cerebrospinal proteins related to microglial and T-cell functions, and show them to reproducibly form functionally-related groups within and across diagnostic categories in 382 participants from the Alzheimer’s Disease Neuro-imaging Initiative as well participants from two independent cohorts. We further show higher levels of proteins related to soluble tumor necrosis factor receptor 1 are associated with reduced risk of conversion to dementia in the multi-centered (p = 0.027) and independent (p = 0.038) cohorts of people with mild cognitive impairment due to predicted Alzheimer’s disease, while higher soluble TREM2 levels associated with slower decline in the dementia stage of Alzheimer’s disease. These inflammatory proteins thus provide prognostic information independent of established Alzheimer’s markers. |
format | Online Article Text |
id | pubmed-8238986 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-82389862021-07-20 Higher CSF sTNFR1-related proteins associate with better prognosis in very early Alzheimer’s disease Hu, William T. Ozturk, Tugba Kollhoff, Alexander Wharton, Whitney Christina Howell, J. Nat Commun Article Neuroinflammation is associated with Alzheimer’s disease, but the application of cerebrospinal fluid measures of inflammatory proteins may be limited by overlapping pathways and relationships between them. In this work, we measure 15 cerebrospinal proteins related to microglial and T-cell functions, and show them to reproducibly form functionally-related groups within and across diagnostic categories in 382 participants from the Alzheimer’s Disease Neuro-imaging Initiative as well participants from two independent cohorts. We further show higher levels of proteins related to soluble tumor necrosis factor receptor 1 are associated with reduced risk of conversion to dementia in the multi-centered (p = 0.027) and independent (p = 0.038) cohorts of people with mild cognitive impairment due to predicted Alzheimer’s disease, while higher soluble TREM2 levels associated with slower decline in the dementia stage of Alzheimer’s disease. These inflammatory proteins thus provide prognostic information independent of established Alzheimer’s markers. Nature Publishing Group UK 2021-06-28 /pmc/articles/PMC8238986/ /pubmed/34183654 http://dx.doi.org/10.1038/s41467-021-24220-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Hu, William T. Ozturk, Tugba Kollhoff, Alexander Wharton, Whitney Christina Howell, J. Higher CSF sTNFR1-related proteins associate with better prognosis in very early Alzheimer’s disease |
title | Higher CSF sTNFR1-related proteins associate with better prognosis in very early Alzheimer’s disease |
title_full | Higher CSF sTNFR1-related proteins associate with better prognosis in very early Alzheimer’s disease |
title_fullStr | Higher CSF sTNFR1-related proteins associate with better prognosis in very early Alzheimer’s disease |
title_full_unstemmed | Higher CSF sTNFR1-related proteins associate with better prognosis in very early Alzheimer’s disease |
title_short | Higher CSF sTNFR1-related proteins associate with better prognosis in very early Alzheimer’s disease |
title_sort | higher csf stnfr1-related proteins associate with better prognosis in very early alzheimer’s disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238986/ https://www.ncbi.nlm.nih.gov/pubmed/34183654 http://dx.doi.org/10.1038/s41467-021-24220-7 |
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