Cargando…

Shot-noise limited, supercontinuum-based optical coherence tomography

We present the first demonstration of shot-noise limited supercontinuum-based spectral domain optical coherence tomography (SD-OCT) with an axial resolution of 5.9 μm at a center wavelength of 1370 nm. Current supercontinuum-based SD-OCT systems cannot be operated in the shot-noise limited detection...

Descripción completa

Detalles Bibliográficos
Autores principales: Rao D. S., Shreesha, Jensen, Mikkel, Grüner-Nielsen, Lars, Olsen, Jesper Toft, Heiduschka, Peter, Kemper, Björn, Schnekenburger, Jürgen, Glud, Martin, Mogensen, Mette, Israelsen, Niels Møller, Bang, Ole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8239030/
https://www.ncbi.nlm.nih.gov/pubmed/34183643
http://dx.doi.org/10.1038/s41377-021-00574-x
_version_ 1783714999756128256
author Rao D. S., Shreesha
Jensen, Mikkel
Grüner-Nielsen, Lars
Olsen, Jesper Toft
Heiduschka, Peter
Kemper, Björn
Schnekenburger, Jürgen
Glud, Martin
Mogensen, Mette
Israelsen, Niels Møller
Bang, Ole
author_facet Rao D. S., Shreesha
Jensen, Mikkel
Grüner-Nielsen, Lars
Olsen, Jesper Toft
Heiduschka, Peter
Kemper, Björn
Schnekenburger, Jürgen
Glud, Martin
Mogensen, Mette
Israelsen, Niels Møller
Bang, Ole
author_sort Rao D. S., Shreesha
collection PubMed
description We present the first demonstration of shot-noise limited supercontinuum-based spectral domain optical coherence tomography (SD-OCT) with an axial resolution of 5.9 μm at a center wavelength of 1370 nm. Current supercontinuum-based SD-OCT systems cannot be operated in the shot-noise limited detection regime because of severe pulse-to-pulse relative intensity noise of the supercontinuum source. To overcome this disadvantage, we have developed a low-noise supercontinuum source based on an all-normal dispersion (ANDi) fiber, pumped by a femtosecond laser. The noise performance of our 90 MHz ANDi fiber-based supercontinuum source is compared to that of two commercial sources operating at 80 and 320 MHz repetition rate. We show that the low-noise of the ANDi fiber-based supercontinuum source improves the OCT images significantly in terms of both higher contrast, better sensitivity, and improved penetration. From SD-OCT imaging of skin, retina, and multilayer stacks we conclude that supercontinuum-based SD-OCT can enter the domain of shot-noise limited detection.
format Online
Article
Text
id pubmed-8239030
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-82390302021-07-16 Shot-noise limited, supercontinuum-based optical coherence tomography Rao D. S., Shreesha Jensen, Mikkel Grüner-Nielsen, Lars Olsen, Jesper Toft Heiduschka, Peter Kemper, Björn Schnekenburger, Jürgen Glud, Martin Mogensen, Mette Israelsen, Niels Møller Bang, Ole Light Sci Appl Article We present the first demonstration of shot-noise limited supercontinuum-based spectral domain optical coherence tomography (SD-OCT) with an axial resolution of 5.9 μm at a center wavelength of 1370 nm. Current supercontinuum-based SD-OCT systems cannot be operated in the shot-noise limited detection regime because of severe pulse-to-pulse relative intensity noise of the supercontinuum source. To overcome this disadvantage, we have developed a low-noise supercontinuum source based on an all-normal dispersion (ANDi) fiber, pumped by a femtosecond laser. The noise performance of our 90 MHz ANDi fiber-based supercontinuum source is compared to that of two commercial sources operating at 80 and 320 MHz repetition rate. We show that the low-noise of the ANDi fiber-based supercontinuum source improves the OCT images significantly in terms of both higher contrast, better sensitivity, and improved penetration. From SD-OCT imaging of skin, retina, and multilayer stacks we conclude that supercontinuum-based SD-OCT can enter the domain of shot-noise limited detection. Nature Publishing Group UK 2021-06-28 /pmc/articles/PMC8239030/ /pubmed/34183643 http://dx.doi.org/10.1038/s41377-021-00574-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Rao D. S., Shreesha
Jensen, Mikkel
Grüner-Nielsen, Lars
Olsen, Jesper Toft
Heiduschka, Peter
Kemper, Björn
Schnekenburger, Jürgen
Glud, Martin
Mogensen, Mette
Israelsen, Niels Møller
Bang, Ole
Shot-noise limited, supercontinuum-based optical coherence tomography
title Shot-noise limited, supercontinuum-based optical coherence tomography
title_full Shot-noise limited, supercontinuum-based optical coherence tomography
title_fullStr Shot-noise limited, supercontinuum-based optical coherence tomography
title_full_unstemmed Shot-noise limited, supercontinuum-based optical coherence tomography
title_short Shot-noise limited, supercontinuum-based optical coherence tomography
title_sort shot-noise limited, supercontinuum-based optical coherence tomography
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8239030/
https://www.ncbi.nlm.nih.gov/pubmed/34183643
http://dx.doi.org/10.1038/s41377-021-00574-x
work_keys_str_mv AT raodsshreesha shotnoiselimitedsupercontinuumbasedopticalcoherencetomography
AT jensenmikkel shotnoiselimitedsupercontinuumbasedopticalcoherencetomography
AT grunernielsenlars shotnoiselimitedsupercontinuumbasedopticalcoherencetomography
AT olsenjespertoft shotnoiselimitedsupercontinuumbasedopticalcoherencetomography
AT heiduschkapeter shotnoiselimitedsupercontinuumbasedopticalcoherencetomography
AT kemperbjorn shotnoiselimitedsupercontinuumbasedopticalcoherencetomography
AT schnekenburgerjurgen shotnoiselimitedsupercontinuumbasedopticalcoherencetomography
AT gludmartin shotnoiselimitedsupercontinuumbasedopticalcoherencetomography
AT mogensenmette shotnoiselimitedsupercontinuumbasedopticalcoherencetomography
AT israelsennielsmøller shotnoiselimitedsupercontinuumbasedopticalcoherencetomography
AT bangole shotnoiselimitedsupercontinuumbasedopticalcoherencetomography