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Shot-noise limited, supercontinuum-based optical coherence tomography
We present the first demonstration of shot-noise limited supercontinuum-based spectral domain optical coherence tomography (SD-OCT) with an axial resolution of 5.9 μm at a center wavelength of 1370 nm. Current supercontinuum-based SD-OCT systems cannot be operated in the shot-noise limited detection...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8239030/ https://www.ncbi.nlm.nih.gov/pubmed/34183643 http://dx.doi.org/10.1038/s41377-021-00574-x |
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author | Rao D. S., Shreesha Jensen, Mikkel Grüner-Nielsen, Lars Olsen, Jesper Toft Heiduschka, Peter Kemper, Björn Schnekenburger, Jürgen Glud, Martin Mogensen, Mette Israelsen, Niels Møller Bang, Ole |
author_facet | Rao D. S., Shreesha Jensen, Mikkel Grüner-Nielsen, Lars Olsen, Jesper Toft Heiduschka, Peter Kemper, Björn Schnekenburger, Jürgen Glud, Martin Mogensen, Mette Israelsen, Niels Møller Bang, Ole |
author_sort | Rao D. S., Shreesha |
collection | PubMed |
description | We present the first demonstration of shot-noise limited supercontinuum-based spectral domain optical coherence tomography (SD-OCT) with an axial resolution of 5.9 μm at a center wavelength of 1370 nm. Current supercontinuum-based SD-OCT systems cannot be operated in the shot-noise limited detection regime because of severe pulse-to-pulse relative intensity noise of the supercontinuum source. To overcome this disadvantage, we have developed a low-noise supercontinuum source based on an all-normal dispersion (ANDi) fiber, pumped by a femtosecond laser. The noise performance of our 90 MHz ANDi fiber-based supercontinuum source is compared to that of two commercial sources operating at 80 and 320 MHz repetition rate. We show that the low-noise of the ANDi fiber-based supercontinuum source improves the OCT images significantly in terms of both higher contrast, better sensitivity, and improved penetration. From SD-OCT imaging of skin, retina, and multilayer stacks we conclude that supercontinuum-based SD-OCT can enter the domain of shot-noise limited detection. |
format | Online Article Text |
id | pubmed-8239030 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-82390302021-07-16 Shot-noise limited, supercontinuum-based optical coherence tomography Rao D. S., Shreesha Jensen, Mikkel Grüner-Nielsen, Lars Olsen, Jesper Toft Heiduschka, Peter Kemper, Björn Schnekenburger, Jürgen Glud, Martin Mogensen, Mette Israelsen, Niels Møller Bang, Ole Light Sci Appl Article We present the first demonstration of shot-noise limited supercontinuum-based spectral domain optical coherence tomography (SD-OCT) with an axial resolution of 5.9 μm at a center wavelength of 1370 nm. Current supercontinuum-based SD-OCT systems cannot be operated in the shot-noise limited detection regime because of severe pulse-to-pulse relative intensity noise of the supercontinuum source. To overcome this disadvantage, we have developed a low-noise supercontinuum source based on an all-normal dispersion (ANDi) fiber, pumped by a femtosecond laser. The noise performance of our 90 MHz ANDi fiber-based supercontinuum source is compared to that of two commercial sources operating at 80 and 320 MHz repetition rate. We show that the low-noise of the ANDi fiber-based supercontinuum source improves the OCT images significantly in terms of both higher contrast, better sensitivity, and improved penetration. From SD-OCT imaging of skin, retina, and multilayer stacks we conclude that supercontinuum-based SD-OCT can enter the domain of shot-noise limited detection. Nature Publishing Group UK 2021-06-28 /pmc/articles/PMC8239030/ /pubmed/34183643 http://dx.doi.org/10.1038/s41377-021-00574-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Rao D. S., Shreesha Jensen, Mikkel Grüner-Nielsen, Lars Olsen, Jesper Toft Heiduschka, Peter Kemper, Björn Schnekenburger, Jürgen Glud, Martin Mogensen, Mette Israelsen, Niels Møller Bang, Ole Shot-noise limited, supercontinuum-based optical coherence tomography |
title | Shot-noise limited, supercontinuum-based optical coherence tomography |
title_full | Shot-noise limited, supercontinuum-based optical coherence tomography |
title_fullStr | Shot-noise limited, supercontinuum-based optical coherence tomography |
title_full_unstemmed | Shot-noise limited, supercontinuum-based optical coherence tomography |
title_short | Shot-noise limited, supercontinuum-based optical coherence tomography |
title_sort | shot-noise limited, supercontinuum-based optical coherence tomography |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8239030/ https://www.ncbi.nlm.nih.gov/pubmed/34183643 http://dx.doi.org/10.1038/s41377-021-00574-x |
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