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Colorectal cancer in Crohn’s disease: a series of 6 cases

BACKGROUND: Colorectal cancer (CRC) is the most malignant complication in patients with Crohn’s disease (CD). We report 6 cases of CD-related CRC treated surgically at our hospital. CASE PRESENTATION: From 2010 to 2016, six CD patients were diagnosed with CRC. All patients were diagnosed with CD at ...

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Autores principales: Ishimaru, Kazuhide, Tominaga, Tetsuro, Nonaka, Takashi, Fukuda, Akiko, Moriyama, Masaaki, Oyama, Shosaburo, Ishii, Mitsutoshi, Sawai, Terumitu, Nagayasu, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8239094/
https://www.ncbi.nlm.nih.gov/pubmed/34181132
http://dx.doi.org/10.1186/s40792-021-01237-0
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author Ishimaru, Kazuhide
Tominaga, Tetsuro
Nonaka, Takashi
Fukuda, Akiko
Moriyama, Masaaki
Oyama, Shosaburo
Ishii, Mitsutoshi
Sawai, Terumitu
Nagayasu, Takeshi
author_facet Ishimaru, Kazuhide
Tominaga, Tetsuro
Nonaka, Takashi
Fukuda, Akiko
Moriyama, Masaaki
Oyama, Shosaburo
Ishii, Mitsutoshi
Sawai, Terumitu
Nagayasu, Takeshi
author_sort Ishimaru, Kazuhide
collection PubMed
description BACKGROUND: Colorectal cancer (CRC) is the most malignant complication in patients with Crohn’s disease (CD). We report 6 cases of CD-related CRC treated surgically at our hospital. CASE PRESENTATION: From 2010 to 2016, six CD patients were diagnosed with CRC. All patients were diagnosed with CD at < 25 years old, and the interval from onset of CD to diagnosis of CRC was > 10 years (range, 15–42 years) in all patients. The histological type of cancer was mucinous carcinoma in two cases, well-differentiated tubular adenocarcinoma in two cases, and moderately differentiated tubular adenocarcinoma in two cases. CRC was detected by screening colonoscopy in three cases (50%), and from clinical symptoms in the remaining three cases (50%). Two cases underwent colonoscopy within 2 months after symptom onset, detecting CRC in the relatively early stage. However, one case was diagnosed with advanced-stage CRC by endoscopy 1 year after symptom onset, and experienced poor prognosis. CONCLUSIONS: Regular surveillance colonoscopy is needed to detect early-stage CRC in CD patients. Clear surveillance methods need to be established based on evidence.
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spelling pubmed-82390942021-07-13 Colorectal cancer in Crohn’s disease: a series of 6 cases Ishimaru, Kazuhide Tominaga, Tetsuro Nonaka, Takashi Fukuda, Akiko Moriyama, Masaaki Oyama, Shosaburo Ishii, Mitsutoshi Sawai, Terumitu Nagayasu, Takeshi Surg Case Rep Case Report BACKGROUND: Colorectal cancer (CRC) is the most malignant complication in patients with Crohn’s disease (CD). We report 6 cases of CD-related CRC treated surgically at our hospital. CASE PRESENTATION: From 2010 to 2016, six CD patients were diagnosed with CRC. All patients were diagnosed with CD at < 25 years old, and the interval from onset of CD to diagnosis of CRC was > 10 years (range, 15–42 years) in all patients. The histological type of cancer was mucinous carcinoma in two cases, well-differentiated tubular adenocarcinoma in two cases, and moderately differentiated tubular adenocarcinoma in two cases. CRC was detected by screening colonoscopy in three cases (50%), and from clinical symptoms in the remaining three cases (50%). Two cases underwent colonoscopy within 2 months after symptom onset, detecting CRC in the relatively early stage. However, one case was diagnosed with advanced-stage CRC by endoscopy 1 year after symptom onset, and experienced poor prognosis. CONCLUSIONS: Regular surveillance colonoscopy is needed to detect early-stage CRC in CD patients. Clear surveillance methods need to be established based on evidence. Springer Berlin Heidelberg 2021-06-28 /pmc/articles/PMC8239094/ /pubmed/34181132 http://dx.doi.org/10.1186/s40792-021-01237-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Case Report
Ishimaru, Kazuhide
Tominaga, Tetsuro
Nonaka, Takashi
Fukuda, Akiko
Moriyama, Masaaki
Oyama, Shosaburo
Ishii, Mitsutoshi
Sawai, Terumitu
Nagayasu, Takeshi
Colorectal cancer in Crohn’s disease: a series of 6 cases
title Colorectal cancer in Crohn’s disease: a series of 6 cases
title_full Colorectal cancer in Crohn’s disease: a series of 6 cases
title_fullStr Colorectal cancer in Crohn’s disease: a series of 6 cases
title_full_unstemmed Colorectal cancer in Crohn’s disease: a series of 6 cases
title_short Colorectal cancer in Crohn’s disease: a series of 6 cases
title_sort colorectal cancer in crohn’s disease: a series of 6 cases
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8239094/
https://www.ncbi.nlm.nih.gov/pubmed/34181132
http://dx.doi.org/10.1186/s40792-021-01237-0
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