Comprehensive Data Integration Approach to Assess Immune Responses and Correlates of RTS,S/AS01-Mediated Protection From Malaria Infection in Controlled Human Malaria Infection Trials

RTS,S/AS01 (GSK) is the world’s first malaria vaccine. However, despite initial efficacy of almost 70% over the first 6 months of follow-up, efficacy waned over time. A deeper understanding of the immune features that contribute to RTS,S/AS01-mediated protection could be beneficial for further vacci...

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Autores principales: Young, William Chad, Carpp, Lindsay N., Chaudhury, Sidhartha, Regules, Jason A., Bergmann-Leitner, Elke S., Ockenhouse, Christian, Wille-Reece, Ulrike, deCamp, Allan C., Hughes, Ellis, Mahoney, Celia, Pallikkuth, Suresh, Pahwa, Savita, Dennison, S. Moses, Mudrak, Sarah V., Alam, S. Munir, Seaton, Kelly E., Spreng, Rachel L., Fallon, Jon, Michell, Ashlin, Ulloa-Montoya, Fernando, Coccia, Margherita, Jongert, Erik, Alter, Galit, Tomaras, Georgia D., Gottardo, Raphael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Big Data
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8239149/
https://www.ncbi.nlm.nih.gov/pubmed/34212134
http://dx.doi.org/10.3389/fdata.2021.672460

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