RNA N (6)-Methyladenosine in Cancer Metastasis: Roles, Mechanisms, and Applications

Cancer metastasis is a symptom of adverse prognosis, a prime origin of therapy failure, and a lethal challenge for cancer patients. N (6)-methyladenosine (m(6)A), the most prevailing modification in messenger RNAs (mRNAs) and non-coding RNAs (ncRNAs) of higher eukaryotes, has attracted increasing at...

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Detalles Bibliográficos
Autores principales: Dang, Qin, Shao, Bo, Zhou, Quanbo, Chen, Chen, Guo, Yaxin, Wang, Guixian, Liu, Jinbo, Kan, Quancheng, Yuan, Weitang, Sun, Zhenqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8239292/
https://www.ncbi.nlm.nih.gov/pubmed/34211849
http://dx.doi.org/10.3389/fonc.2021.681781
Descripción
Sumario:Cancer metastasis is a symptom of adverse prognosis, a prime origin of therapy failure, and a lethal challenge for cancer patients. N (6)-methyladenosine (m(6)A), the most prevailing modification in messenger RNAs (mRNAs) and non-coding RNAs (ncRNAs) of higher eukaryotes, has attracted increasing attention. Growing studies have verified the pivotal roles of m(6)A methylation in controlling mRNAs and ncRNAs in diverse physiological processes. Remarkably, recent findings have showed that aberrant methylation of m(6)A-related RNAs could influence cancer metastasis. In this review, we illuminate how m(6)A modifiers act on mRNAs and ncRNAs and modulate metastasis in several cancers, and put forward the clinical application prospects of m(6)A methylation.

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