RNA N (6)-Methyladenosine in Cancer Metastasis: Roles, Mechanisms, and Applications

Cancer metastasis is a symptom of adverse prognosis, a prime origin of therapy failure, and a lethal challenge for cancer patients. N (6)-methyladenosine (m(6)A), the most prevailing modification in messenger RNAs (mRNAs) and non-coding RNAs (ncRNAs) of higher eukaryotes, has attracted increasing at...

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Autores principales: Dang, Qin, Shao, Bo, Zhou, Quanbo, Chen, Chen, Guo, Yaxin, Wang, Guixian, Liu, Jinbo, Kan, Quancheng, Yuan, Weitang, Sun, Zhenqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8239292/
https://www.ncbi.nlm.nih.gov/pubmed/34211849
http://dx.doi.org/10.3389/fonc.2021.681781
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author Dang, Qin
Shao, Bo
Zhou, Quanbo
Chen, Chen
Guo, Yaxin
Wang, Guixian
Liu, Jinbo
Kan, Quancheng
Yuan, Weitang
Sun, Zhenqiang
author_facet Dang, Qin
Shao, Bo
Zhou, Quanbo
Chen, Chen
Guo, Yaxin
Wang, Guixian
Liu, Jinbo
Kan, Quancheng
Yuan, Weitang
Sun, Zhenqiang
author_sort Dang, Qin
collection PubMed
description Cancer metastasis is a symptom of adverse prognosis, a prime origin of therapy failure, and a lethal challenge for cancer patients. N (6)-methyladenosine (m(6)A), the most prevailing modification in messenger RNAs (mRNAs) and non-coding RNAs (ncRNAs) of higher eukaryotes, has attracted increasing attention. Growing studies have verified the pivotal roles of m(6)A methylation in controlling mRNAs and ncRNAs in diverse physiological processes. Remarkably, recent findings have showed that aberrant methylation of m(6)A-related RNAs could influence cancer metastasis. In this review, we illuminate how m(6)A modifiers act on mRNAs and ncRNAs and modulate metastasis in several cancers, and put forward the clinical application prospects of m(6)A methylation.
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spelling pubmed-82392922021-06-30 RNA N (6)-Methyladenosine in Cancer Metastasis: Roles, Mechanisms, and Applications Dang, Qin Shao, Bo Zhou, Quanbo Chen, Chen Guo, Yaxin Wang, Guixian Liu, Jinbo Kan, Quancheng Yuan, Weitang Sun, Zhenqiang Front Oncol Oncology Cancer metastasis is a symptom of adverse prognosis, a prime origin of therapy failure, and a lethal challenge for cancer patients. N (6)-methyladenosine (m(6)A), the most prevailing modification in messenger RNAs (mRNAs) and non-coding RNAs (ncRNAs) of higher eukaryotes, has attracted increasing attention. Growing studies have verified the pivotal roles of m(6)A methylation in controlling mRNAs and ncRNAs in diverse physiological processes. Remarkably, recent findings have showed that aberrant methylation of m(6)A-related RNAs could influence cancer metastasis. In this review, we illuminate how m(6)A modifiers act on mRNAs and ncRNAs and modulate metastasis in several cancers, and put forward the clinical application prospects of m(6)A methylation. Frontiers Media S.A. 2021-06-15 /pmc/articles/PMC8239292/ /pubmed/34211849 http://dx.doi.org/10.3389/fonc.2021.681781 Text en Copyright © 2021 Dang, Shao, Zhou, Chen, Guo, Wang, Liu, Kan, Yuan and Sun https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Dang, Qin
Shao, Bo
Zhou, Quanbo
Chen, Chen
Guo, Yaxin
Wang, Guixian
Liu, Jinbo
Kan, Quancheng
Yuan, Weitang
Sun, Zhenqiang
RNA N (6)-Methyladenosine in Cancer Metastasis: Roles, Mechanisms, and Applications
title RNA N (6)-Methyladenosine in Cancer Metastasis: Roles, Mechanisms, and Applications
title_full RNA N (6)-Methyladenosine in Cancer Metastasis: Roles, Mechanisms, and Applications
title_fullStr RNA N (6)-Methyladenosine in Cancer Metastasis: Roles, Mechanisms, and Applications
title_full_unstemmed RNA N (6)-Methyladenosine in Cancer Metastasis: Roles, Mechanisms, and Applications
title_short RNA N (6)-Methyladenosine in Cancer Metastasis: Roles, Mechanisms, and Applications
title_sort rna n (6)-methyladenosine in cancer metastasis: roles, mechanisms, and applications
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8239292/
https://www.ncbi.nlm.nih.gov/pubmed/34211849
http://dx.doi.org/10.3389/fonc.2021.681781
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