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An IRF1-IRF4 Toggle-Switch Controls Tolerogenic and Immunogenic Transcriptional Programming in Human Langerhans Cells

Langerhans cells (LCs) reside in the epidermis as a dense network of immune system sentinels, coordinating both immunogenic and tolerogenic immune responses. To determine molecular switches directing induction of LC immune activation, we performed mathematical modelling of gene regulatory networks i...

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Detalles Bibliográficos
Autores principales:	Davies, James, Vallejo, Andres F., Sirvent, Sofia, Porter, Gemma, Clayton, Kalum, Qumbelo, Yamkela, Stumpf, Patrick, West, Jonathan, Gray, Clive M., Chigorimbo-Murefu, Nyaradzo T. L., MacArthur, Ben, Polak, Marta E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8239435/ https://www.ncbi.nlm.nih.gov/pubmed/34211464 http://dx.doi.org/10.3389/fimmu.2021.665312

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