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Early B-cell factors involve in the tumorigenesis and predict the overall survival of gastric cancer
Gastric cancer (GC) is a heavy health burden around the world, which is the fifth most frequent tumor and leads to the third most common cancer-related deaths. It is urgent to identify prognostic markers as the guideline for personalized treatment and follow-up. We accessed the prognostic value of E...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8239495/ https://www.ncbi.nlm.nih.gov/pubmed/34100918 http://dx.doi.org/10.1042/BSR20210055 |
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author | Wang, Qing Liang, Jiahong Hu, Xianyu Gu, Songgang Xu, Qiaodong Yan, Jiang |
author_facet | Wang, Qing Liang, Jiahong Hu, Xianyu Gu, Songgang Xu, Qiaodong Yan, Jiang |
author_sort | Wang, Qing |
collection | PubMed |
description | Gastric cancer (GC) is a heavy health burden around the world, which is the fifth most frequent tumor and leads to the third most common cancer-related deaths. It is urgent to identify prognostic markers as the guideline for personalized treatment and follow-up. We accessed the prognostic value of Early B-cell factors (EBFs) in GC. A total of 415 GC tissues and 34 normal tissues from The Cancer Genome Atlas Stomach Adenocarcinoma (TCGA-STAD) cohort, 616 external patients from GSE15459, GSE22377, GSE51105, GSE62245 were enrolled for analysis. Univariate and multivariate Cox regression analyses were employed to evaluate the sole and integrative prognostic value of EBFs, respectively. Genetic alterations, DNA methylation of EBFs were also evaluated, as well as the involved signaling pathways. We revealed that increased EBFs associated with the poor prognosis of GC patients, the prognostic model was established in TCGA-STAD cohort, and validated in Gene Expression Omnibus (GEO) cohorts, with effectiveness in both HER2 positive and negative patients. DNA methylation was involved in the impact on prognosis. Cell cycle, immune-associated, and MAPK pathways were influenced by EBFs. Anti-CTLA4 immunotherapy is more suitable for EBFs determining high-risk groups, but not anti-PD-1/PD-L1 therapy. 5-Fluorouracil, methotrexate, vorinostat are suitable to inhibit the function of EBFs. Our new findings provide novel insight into the prediction of prognosis and clinical treatment of GC patients based on EBFs. |
format | Online Article Text |
id | pubmed-8239495 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82394952021-07-09 Early B-cell factors involve in the tumorigenesis and predict the overall survival of gastric cancer Wang, Qing Liang, Jiahong Hu, Xianyu Gu, Songgang Xu, Qiaodong Yan, Jiang Biosci Rep Cancer Gastric cancer (GC) is a heavy health burden around the world, which is the fifth most frequent tumor and leads to the third most common cancer-related deaths. It is urgent to identify prognostic markers as the guideline for personalized treatment and follow-up. We accessed the prognostic value of Early B-cell factors (EBFs) in GC. A total of 415 GC tissues and 34 normal tissues from The Cancer Genome Atlas Stomach Adenocarcinoma (TCGA-STAD) cohort, 616 external patients from GSE15459, GSE22377, GSE51105, GSE62245 were enrolled for analysis. Univariate and multivariate Cox regression analyses were employed to evaluate the sole and integrative prognostic value of EBFs, respectively. Genetic alterations, DNA methylation of EBFs were also evaluated, as well as the involved signaling pathways. We revealed that increased EBFs associated with the poor prognosis of GC patients, the prognostic model was established in TCGA-STAD cohort, and validated in Gene Expression Omnibus (GEO) cohorts, with effectiveness in both HER2 positive and negative patients. DNA methylation was involved in the impact on prognosis. Cell cycle, immune-associated, and MAPK pathways were influenced by EBFs. Anti-CTLA4 immunotherapy is more suitable for EBFs determining high-risk groups, but not anti-PD-1/PD-L1 therapy. 5-Fluorouracil, methotrexate, vorinostat are suitable to inhibit the function of EBFs. Our new findings provide novel insight into the prediction of prognosis and clinical treatment of GC patients based on EBFs. Portland Press Ltd. 2021-06-28 /pmc/articles/PMC8239495/ /pubmed/34100918 http://dx.doi.org/10.1042/BSR20210055 Text en © 2021 The Author(s). https://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Cancer Wang, Qing Liang, Jiahong Hu, Xianyu Gu, Songgang Xu, Qiaodong Yan, Jiang Early B-cell factors involve in the tumorigenesis and predict the overall survival of gastric cancer |
title | Early B-cell factors involve in the tumorigenesis and predict the overall survival of gastric cancer |
title_full | Early B-cell factors involve in the tumorigenesis and predict the overall survival of gastric cancer |
title_fullStr | Early B-cell factors involve in the tumorigenesis and predict the overall survival of gastric cancer |
title_full_unstemmed | Early B-cell factors involve in the tumorigenesis and predict the overall survival of gastric cancer |
title_short | Early B-cell factors involve in the tumorigenesis and predict the overall survival of gastric cancer |
title_sort | early b-cell factors involve in the tumorigenesis and predict the overall survival of gastric cancer |
topic | Cancer |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8239495/ https://www.ncbi.nlm.nih.gov/pubmed/34100918 http://dx.doi.org/10.1042/BSR20210055 |
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