Recombinant sclerostin inhibits bone formation in vitro and in a mouse model of sclerosteosis

BACKGROUND: Sclerosteosis, a severe autosomal recessive sclerosing skeletal dysplasia characterised by excessive bone formation, is caused by absence of sclerostin, a negative regulator of bone formation that binds LRP5/6 Wnt co-receptors. Current treatment is limited to surgical management of sympt...

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Detalles Bibliográficos
Autores principales: Dreyer, Timothy, Shah, Mittal, Doyle, Carl, Greenslade, Kevin, Penney, Mark, Creeke, Paul, Kotian, Apoorva, Ke, Hua Zhu, Naidoo, Vinny, Holdsworth, Gill
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chinese Speaking Orthopaedic Society 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8239522/
https://www.ncbi.nlm.nih.gov/pubmed/34249611
http://dx.doi.org/10.1016/j.jot.2021.05.005

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