Dabigatran mitigates cisplatin-mediated nephrotoxicity through down regulation of thrombin pathway

INTRODUCTION: Cisplatin (CDDP) nephrotoxicity is one of the most significant complications limiting its use in cancer therapy. OBJECTIVES: This study investigated the pivotal role played by thrombin in CDDP-mediated nephrotoxicity. This work also aimed to clarify the possible preventive effect of Da...

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Detalles Bibliográficos
Autores principales: Ewees, Mohamed Gamal El-Din, Abdel-Bakky, Mohamed Sadek, Bayoumi, Asmaa Mostafa Ahmed, Abo-Saif, Ali Ahmed, Altowayan, Waleed Mohammad, Alharbi, Khalid Saad, Messiha, Basim Anwar Shehata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Pharmaceutical Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8240102/
https://www.ncbi.nlm.nih.gov/pubmed/34194837
http://dx.doi.org/10.1016/j.jare.2020.12.014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8240102/
https://www.ncbi.nlm.nih.gov/pubmed/34194837
http://dx.doi.org/10.1016/j.jare.2020.12.014

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