Cardiac effects and clinical applications of MG53

Heart disease remains the leading cause of mortality globally, so further investigation is required to identify its underlying mechanisms and potential targets for treatment and prevention. Mitsugumin 53 (MG53), also known as TRIM72, is a TRIM family protein that was found to be involved in cell mem...

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Autores principales: Zhong, Weina, Benissan-Messan, Dathe Z., Ma, Jianjie, Cai, Chuanxi, Lee, Peter H. U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8240287/
https://www.ncbi.nlm.nih.gov/pubmed/34183055
http://dx.doi.org/10.1186/s13578-021-00629-x
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author Zhong, Weina
Benissan-Messan, Dathe Z.
Ma, Jianjie
Cai, Chuanxi
Lee, Peter H. U.
author_facet Zhong, Weina
Benissan-Messan, Dathe Z.
Ma, Jianjie
Cai, Chuanxi
Lee, Peter H. U.
author_sort Zhong, Weina
collection PubMed
description Heart disease remains the leading cause of mortality globally, so further investigation is required to identify its underlying mechanisms and potential targets for treatment and prevention. Mitsugumin 53 (MG53), also known as TRIM72, is a TRIM family protein that was found to be involved in cell membrane repair and primarily found in striated muscle. Its role in skeletal muscle regeneration and myogenesis has been well documented. However, accumulating evidence suggests that MG53 has a potentially protective role in heart tissue, including in ischemia/reperfusion injury of the heart, cardiomyocyte membrane injury repair, and atrial fibrosis. This review summarizes the regulatory role of MG53 in cardiac tissues, current debates regarding MG53 in diabetes and diabetic cardiomyopathy, as well as highlights potential clinical applications of MG53 in treating cardiac pathologies.
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spelling pubmed-82402872021-06-30 Cardiac effects and clinical applications of MG53 Zhong, Weina Benissan-Messan, Dathe Z. Ma, Jianjie Cai, Chuanxi Lee, Peter H. U. Cell Biosci Review Heart disease remains the leading cause of mortality globally, so further investigation is required to identify its underlying mechanisms and potential targets for treatment and prevention. Mitsugumin 53 (MG53), also known as TRIM72, is a TRIM family protein that was found to be involved in cell membrane repair and primarily found in striated muscle. Its role in skeletal muscle regeneration and myogenesis has been well documented. However, accumulating evidence suggests that MG53 has a potentially protective role in heart tissue, including in ischemia/reperfusion injury of the heart, cardiomyocyte membrane injury repair, and atrial fibrosis. This review summarizes the regulatory role of MG53 in cardiac tissues, current debates regarding MG53 in diabetes and diabetic cardiomyopathy, as well as highlights potential clinical applications of MG53 in treating cardiac pathologies. BioMed Central 2021-06-28 /pmc/articles/PMC8240287/ /pubmed/34183055 http://dx.doi.org/10.1186/s13578-021-00629-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Zhong, Weina
Benissan-Messan, Dathe Z.
Ma, Jianjie
Cai, Chuanxi
Lee, Peter H. U.
Cardiac effects and clinical applications of MG53
title Cardiac effects and clinical applications of MG53
title_full Cardiac effects and clinical applications of MG53
title_fullStr Cardiac effects and clinical applications of MG53
title_full_unstemmed Cardiac effects and clinical applications of MG53
title_short Cardiac effects and clinical applications of MG53
title_sort cardiac effects and clinical applications of mg53
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8240287/
https://www.ncbi.nlm.nih.gov/pubmed/34183055
http://dx.doi.org/10.1186/s13578-021-00629-x
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