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The burden and management of anemia in Greek patients with inflammatory bowel disease: a retrospective, multicenter, observational study

BACKGROUND: Anemia is a common extraintestinal manifestation of Inflammatory Bowel Disease (IBD) affecting negatively the patients’ quality of life. The aim of this study was to determine the frequency and real-life management of anemia in IBD patients in Greece. METHODS: This study was conducted in...

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Autores principales: Foteinogiannopoulou, Kalliopi, Karmiris, Konstantinos, Axiaris, Georgios, Velegraki, Magdalini, Gklavas, Antonios, Kapizioni, Christina, Karageorgos, Charalabos, Kateri, Christina, Katsoula, Anastasia, Kokkotis, Georgios, Koureta, Evgenia, Lamouri, Charikleia, Markopoulos, Panagiotis, Palatianou, Maria, Pastras, Ploutarchos, Fasoulas, Konstantinos, Giouleme, Olga, Zampeli, Evanthia, Theodoropoulou, Aggeliki, Theocharis, Georgios, Thomopoulos, Konstantinos, Karatzas, Pantelis, Katsanos, Konstantinos H., Kapsoritakis, Andreas, Kourikou, Anastasia, Mathou, Nikoleta, Manolakopoulos, Spilios, Michalopoulos, Georgios, Michopoulos, Spyridon, Boubonaris, Alexandros, Bamias, Giorgos, Papadopoulos, Vasileios, Papatheodoridis, George, Papaconstantinou, Ioannis, Pachiadakis, Ioannis, Soufleris, Konstantinos, Tzouvala, Maria, Triantos, Christos, Tsironi, Eftychia, Christodoulou, Dimitrios K., Koutroubakis, Ioannis E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8240305/
https://www.ncbi.nlm.nih.gov/pubmed/34187376
http://dx.doi.org/10.1186/s12876-021-01826-1
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author Foteinogiannopoulou, Kalliopi
Karmiris, Konstantinos
Axiaris, Georgios
Velegraki, Magdalini
Gklavas, Antonios
Kapizioni, Christina
Karageorgos, Charalabos
Kateri, Christina
Katsoula, Anastasia
Kokkotis, Georgios
Koureta, Evgenia
Lamouri, Charikleia
Markopoulos, Panagiotis
Palatianou, Maria
Pastras, Ploutarchos
Fasoulas, Konstantinos
Giouleme, Olga
Zampeli, Evanthia
Theodoropoulou, Aggeliki
Theocharis, Georgios
Thomopoulos, Konstantinos
Karatzas, Pantelis
Katsanos, Konstantinos H.
Kapsoritakis, Andreas
Kourikou, Anastasia
Mathou, Nikoleta
Manolakopoulos, Spilios
Michalopoulos, Georgios
Michopoulos, Spyridon
Boubonaris, Alexandros
Bamias, Giorgos
Papadopoulos, Vasileios
Papatheodoridis, George
Papaconstantinou, Ioannis
Pachiadakis, Ioannis
Soufleris, Konstantinos
Tzouvala, Maria
Triantos, Christos
Tsironi, Eftychia
Christodoulou, Dimitrios K.
Koutroubakis, Ioannis E.
author_facet Foteinogiannopoulou, Kalliopi
Karmiris, Konstantinos
Axiaris, Georgios
Velegraki, Magdalini
Gklavas, Antonios
Kapizioni, Christina
Karageorgos, Charalabos
Kateri, Christina
Katsoula, Anastasia
Kokkotis, Georgios
Koureta, Evgenia
Lamouri, Charikleia
Markopoulos, Panagiotis
Palatianou, Maria
Pastras, Ploutarchos
Fasoulas, Konstantinos
Giouleme, Olga
Zampeli, Evanthia
Theodoropoulou, Aggeliki
Theocharis, Georgios
Thomopoulos, Konstantinos
Karatzas, Pantelis
Katsanos, Konstantinos H.
Kapsoritakis, Andreas
Kourikou, Anastasia
Mathou, Nikoleta
Manolakopoulos, Spilios
Michalopoulos, Georgios
Michopoulos, Spyridon
Boubonaris, Alexandros
Bamias, Giorgos
Papadopoulos, Vasileios
Papatheodoridis, George
Papaconstantinou, Ioannis
Pachiadakis, Ioannis
Soufleris, Konstantinos
Tzouvala, Maria
Triantos, Christos
Tsironi, Eftychia
Christodoulou, Dimitrios K.
Koutroubakis, Ioannis E.
author_sort Foteinogiannopoulou, Kalliopi
collection PubMed
description BACKGROUND: Anemia is a common extraintestinal manifestation of Inflammatory Bowel Disease (IBD) affecting negatively the patients’ quality of life. The aim of this study was to determine the frequency and real-life management of anemia in IBD patients in Greece. METHODS: This study was conducted in 17 Greek IBD referral centers. Demographic, clinical, laboratory, IBD and anemia treatment data were collected and analyzed retrospectively. RESULTS: A total of 1394 IBD patients [560 ulcerative colitis (UC), 834 Crohn’s disease (CD)] were enrolled. Anemia at any time was reported in 687 (49.3%) patients of whom 413 (29.6%) had episodic and 274 (19.7%) had recurrent/persistent anemia. Anemia was diagnosed before IBD in 45 (6.5%), along with IBD in 269 (39.2%) and after IBD in 373 (54.3%) patients. In the multivariate analysis the presence of extraintestinal manifestations (p = 0.0008), IBD duration (p = 0.026), IBD related surgeries and hospitalizations (p = 0.026 and p = 0.004 accordingly) were risk factors of recurrent/persistent anemia. Serum ferritin was measured in 839 (60.2%) IBD patients. Among anemic patients, 535 (77.9%) received treatment. Iron supplementation was administered in 485 (90.6%) patients, oral in 142 (29.3%) and intravenous in 393 (81%). CONCLUSIONS: The frequency of anemia in IBD patients, followed at Greek referral centers, is approximately 50%. Development of recurrent/persistent anemia may be observed in 20% of cases and is independently associated with the presence of extraintestinal manifestations, IBD duration, IBD related surgeries and hospitalizations. Anemia treatment is administered in up to [Formula: see text] of anemia IBD patients with the majority of them receiving iron intravenously.
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spelling pubmed-82403052021-06-30 The burden and management of anemia in Greek patients with inflammatory bowel disease: a retrospective, multicenter, observational study Foteinogiannopoulou, Kalliopi Karmiris, Konstantinos Axiaris, Georgios Velegraki, Magdalini Gklavas, Antonios Kapizioni, Christina Karageorgos, Charalabos Kateri, Christina Katsoula, Anastasia Kokkotis, Georgios Koureta, Evgenia Lamouri, Charikleia Markopoulos, Panagiotis Palatianou, Maria Pastras, Ploutarchos Fasoulas, Konstantinos Giouleme, Olga Zampeli, Evanthia Theodoropoulou, Aggeliki Theocharis, Georgios Thomopoulos, Konstantinos Karatzas, Pantelis Katsanos, Konstantinos H. Kapsoritakis, Andreas Kourikou, Anastasia Mathou, Nikoleta Manolakopoulos, Spilios Michalopoulos, Georgios Michopoulos, Spyridon Boubonaris, Alexandros Bamias, Giorgos Papadopoulos, Vasileios Papatheodoridis, George Papaconstantinou, Ioannis Pachiadakis, Ioannis Soufleris, Konstantinos Tzouvala, Maria Triantos, Christos Tsironi, Eftychia Christodoulou, Dimitrios K. Koutroubakis, Ioannis E. BMC Gastroenterol Research Article BACKGROUND: Anemia is a common extraintestinal manifestation of Inflammatory Bowel Disease (IBD) affecting negatively the patients’ quality of life. The aim of this study was to determine the frequency and real-life management of anemia in IBD patients in Greece. METHODS: This study was conducted in 17 Greek IBD referral centers. Demographic, clinical, laboratory, IBD and anemia treatment data were collected and analyzed retrospectively. RESULTS: A total of 1394 IBD patients [560 ulcerative colitis (UC), 834 Crohn’s disease (CD)] were enrolled. Anemia at any time was reported in 687 (49.3%) patients of whom 413 (29.6%) had episodic and 274 (19.7%) had recurrent/persistent anemia. Anemia was diagnosed before IBD in 45 (6.5%), along with IBD in 269 (39.2%) and after IBD in 373 (54.3%) patients. In the multivariate analysis the presence of extraintestinal manifestations (p = 0.0008), IBD duration (p = 0.026), IBD related surgeries and hospitalizations (p = 0.026 and p = 0.004 accordingly) were risk factors of recurrent/persistent anemia. Serum ferritin was measured in 839 (60.2%) IBD patients. Among anemic patients, 535 (77.9%) received treatment. Iron supplementation was administered in 485 (90.6%) patients, oral in 142 (29.3%) and intravenous in 393 (81%). CONCLUSIONS: The frequency of anemia in IBD patients, followed at Greek referral centers, is approximately 50%. Development of recurrent/persistent anemia may be observed in 20% of cases and is independently associated with the presence of extraintestinal manifestations, IBD duration, IBD related surgeries and hospitalizations. Anemia treatment is administered in up to [Formula: see text] of anemia IBD patients with the majority of them receiving iron intravenously. BioMed Central 2021-06-29 /pmc/articles/PMC8240305/ /pubmed/34187376 http://dx.doi.org/10.1186/s12876-021-01826-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Foteinogiannopoulou, Kalliopi
Karmiris, Konstantinos
Axiaris, Georgios
Velegraki, Magdalini
Gklavas, Antonios
Kapizioni, Christina
Karageorgos, Charalabos
Kateri, Christina
Katsoula, Anastasia
Kokkotis, Georgios
Koureta, Evgenia
Lamouri, Charikleia
Markopoulos, Panagiotis
Palatianou, Maria
Pastras, Ploutarchos
Fasoulas, Konstantinos
Giouleme, Olga
Zampeli, Evanthia
Theodoropoulou, Aggeliki
Theocharis, Georgios
Thomopoulos, Konstantinos
Karatzas, Pantelis
Katsanos, Konstantinos H.
Kapsoritakis, Andreas
Kourikou, Anastasia
Mathou, Nikoleta
Manolakopoulos, Spilios
Michalopoulos, Georgios
Michopoulos, Spyridon
Boubonaris, Alexandros
Bamias, Giorgos
Papadopoulos, Vasileios
Papatheodoridis, George
Papaconstantinou, Ioannis
Pachiadakis, Ioannis
Soufleris, Konstantinos
Tzouvala, Maria
Triantos, Christos
Tsironi, Eftychia
Christodoulou, Dimitrios K.
Koutroubakis, Ioannis E.
The burden and management of anemia in Greek patients with inflammatory bowel disease: a retrospective, multicenter, observational study
title The burden and management of anemia in Greek patients with inflammatory bowel disease: a retrospective, multicenter, observational study
title_full The burden and management of anemia in Greek patients with inflammatory bowel disease: a retrospective, multicenter, observational study
title_fullStr The burden and management of anemia in Greek patients with inflammatory bowel disease: a retrospective, multicenter, observational study
title_full_unstemmed The burden and management of anemia in Greek patients with inflammatory bowel disease: a retrospective, multicenter, observational study
title_short The burden and management of anemia in Greek patients with inflammatory bowel disease: a retrospective, multicenter, observational study
title_sort burden and management of anemia in greek patients with inflammatory bowel disease: a retrospective, multicenter, observational study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8240305/
https://www.ncbi.nlm.nih.gov/pubmed/34187376
http://dx.doi.org/10.1186/s12876-021-01826-1
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