Cargando…

Case Report: Extragonadal Yolk Sac Tumors Originating From the Endometrium and the Broad Ligament: A Case Series and Literature Review

Yolk sac tumors (YSTs) of the endometrium and the broad ligament are very rare, with only 29 cases and one case of each other reported before in the English literature. Due to lack of standard guidelines, the treatment strategies of these diseases are controversial. Here, we share two cases of YSTs...

Descripción completa

Detalles Bibliográficos
Autores principales: Cheng, Xianzhong, Zhao, Qian, Xu, Xia, Guo, Wenwen, Gu, Hongyuan, Zhou, Rui, Chen, Chen, Ma, Dawei, Wu, Yinan, Ni, Jing, Chen, Xiaoxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8240588/
https://www.ncbi.nlm.nih.gov/pubmed/34211846
http://dx.doi.org/10.3389/fonc.2021.672434
_version_ 1783715241732866048
author Cheng, Xianzhong
Zhao, Qian
Xu, Xia
Guo, Wenwen
Gu, Hongyuan
Zhou, Rui
Chen, Chen
Ma, Dawei
Wu, Yinan
Ni, Jing
Chen, Xiaoxiang
author_facet Cheng, Xianzhong
Zhao, Qian
Xu, Xia
Guo, Wenwen
Gu, Hongyuan
Zhou, Rui
Chen, Chen
Ma, Dawei
Wu, Yinan
Ni, Jing
Chen, Xiaoxiang
author_sort Cheng, Xianzhong
collection PubMed
description Yolk sac tumors (YSTs) of the endometrium and the broad ligament are very rare, with only 29 cases and one case of each other reported before in the English literature. Due to lack of standard guidelines, the treatment strategies of these diseases are controversial. Here, we share two cases of YSTs originating from the endometrium and the broad ligament respectively and review related literature. A 35-year-old woman was diagnosed with endometrial YST in our center and underwent surgery followed by chemotherapy with BEP (bleomycin, cisplatin and etoposide) regimen for six courses. After follow-up for 21 months, there is still no evidence of relapse. Another 36-year-old woman was admitted to our department with YST of the broad ligament. She was treated with surgery followed by chemotherapy with BEP regimen and was lost to follow-up after completing therapy. The case of endometrial YST we shared was similar to cases reported before, while the case with YST of the broad ligament we shared was the second case reported worldwide. Both of these two cases were treated with surgery combined with chemotherapy with BEP regimen.
format Online
Article
Text
id pubmed-8240588
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-82405882021-06-30 Case Report: Extragonadal Yolk Sac Tumors Originating From the Endometrium and the Broad Ligament: A Case Series and Literature Review Cheng, Xianzhong Zhao, Qian Xu, Xia Guo, Wenwen Gu, Hongyuan Zhou, Rui Chen, Chen Ma, Dawei Wu, Yinan Ni, Jing Chen, Xiaoxiang Front Oncol Oncology Yolk sac tumors (YSTs) of the endometrium and the broad ligament are very rare, with only 29 cases and one case of each other reported before in the English literature. Due to lack of standard guidelines, the treatment strategies of these diseases are controversial. Here, we share two cases of YSTs originating from the endometrium and the broad ligament respectively and review related literature. A 35-year-old woman was diagnosed with endometrial YST in our center and underwent surgery followed by chemotherapy with BEP (bleomycin, cisplatin and etoposide) regimen for six courses. After follow-up for 21 months, there is still no evidence of relapse. Another 36-year-old woman was admitted to our department with YST of the broad ligament. She was treated with surgery followed by chemotherapy with BEP regimen and was lost to follow-up after completing therapy. The case of endometrial YST we shared was similar to cases reported before, while the case with YST of the broad ligament we shared was the second case reported worldwide. Both of these two cases were treated with surgery combined with chemotherapy with BEP regimen. Frontiers Media S.A. 2021-06-11 /pmc/articles/PMC8240588/ /pubmed/34211846 http://dx.doi.org/10.3389/fonc.2021.672434 Text en Copyright © 2021 Cheng, Zhao, Xu, Guo, Gu, Zhou, Chen, Ma, Wu, Ni and Chen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Cheng, Xianzhong
Zhao, Qian
Xu, Xia
Guo, Wenwen
Gu, Hongyuan
Zhou, Rui
Chen, Chen
Ma, Dawei
Wu, Yinan
Ni, Jing
Chen, Xiaoxiang
Case Report: Extragonadal Yolk Sac Tumors Originating From the Endometrium and the Broad Ligament: A Case Series and Literature Review
title Case Report: Extragonadal Yolk Sac Tumors Originating From the Endometrium and the Broad Ligament: A Case Series and Literature Review
title_full Case Report: Extragonadal Yolk Sac Tumors Originating From the Endometrium and the Broad Ligament: A Case Series and Literature Review
title_fullStr Case Report: Extragonadal Yolk Sac Tumors Originating From the Endometrium and the Broad Ligament: A Case Series and Literature Review
title_full_unstemmed Case Report: Extragonadal Yolk Sac Tumors Originating From the Endometrium and the Broad Ligament: A Case Series and Literature Review
title_short Case Report: Extragonadal Yolk Sac Tumors Originating From the Endometrium and the Broad Ligament: A Case Series and Literature Review
title_sort case report: extragonadal yolk sac tumors originating from the endometrium and the broad ligament: a case series and literature review
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8240588/
https://www.ncbi.nlm.nih.gov/pubmed/34211846
http://dx.doi.org/10.3389/fonc.2021.672434
work_keys_str_mv AT chengxianzhong casereportextragonadalyolksactumorsoriginatingfromtheendometriumandthebroadligamentacaseseriesandliteraturereview
AT zhaoqian casereportextragonadalyolksactumorsoriginatingfromtheendometriumandthebroadligamentacaseseriesandliteraturereview
AT xuxia casereportextragonadalyolksactumorsoriginatingfromtheendometriumandthebroadligamentacaseseriesandliteraturereview
AT guowenwen casereportextragonadalyolksactumorsoriginatingfromtheendometriumandthebroadligamentacaseseriesandliteraturereview
AT guhongyuan casereportextragonadalyolksactumorsoriginatingfromtheendometriumandthebroadligamentacaseseriesandliteraturereview
AT zhourui casereportextragonadalyolksactumorsoriginatingfromtheendometriumandthebroadligamentacaseseriesandliteraturereview
AT chenchen casereportextragonadalyolksactumorsoriginatingfromtheendometriumandthebroadligamentacaseseriesandliteraturereview
AT madawei casereportextragonadalyolksactumorsoriginatingfromtheendometriumandthebroadligamentacaseseriesandliteraturereview
AT wuyinan casereportextragonadalyolksactumorsoriginatingfromtheendometriumandthebroadligamentacaseseriesandliteraturereview
AT nijing casereportextragonadalyolksactumorsoriginatingfromtheendometriumandthebroadligamentacaseseriesandliteraturereview
AT chenxiaoxiang casereportextragonadalyolksactumorsoriginatingfromtheendometriumandthebroadligamentacaseseriesandliteraturereview