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Safety and Success of Lumbar Puncture in Young Infants: A Prospective Observational Study

Objective: This study aims to evaluate safety and success rates of lumbar puncture (LP) and to identify factors associated with adverse events or failure of LP in infants. Methods: This two-center prospective observational study investigated infants younger than 90 days of age who underwent LP. Need...

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Autores principales: Bedetti, Luca, Lugli, Licia, Marrozzini, Lucia, Baraldi, Alessandro, Leone, Federica, Baroni, Lorenza, Lucaccioni, Laura, Rossi, Cecilia, Roversi, Maria F., D'Amico, Roberto, Iughetti, Lorenzo, Berardi, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8240589/
https://www.ncbi.nlm.nih.gov/pubmed/34211946
http://dx.doi.org/10.3389/fped.2021.692652
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author Bedetti, Luca
Lugli, Licia
Marrozzini, Lucia
Baraldi, Alessandro
Leone, Federica
Baroni, Lorenza
Lucaccioni, Laura
Rossi, Cecilia
Roversi, Maria F.
D'Amico, Roberto
Iughetti, Lorenzo
Berardi, Alberto
author_facet Bedetti, Luca
Lugli, Licia
Marrozzini, Lucia
Baraldi, Alessandro
Leone, Federica
Baroni, Lorenza
Lucaccioni, Laura
Rossi, Cecilia
Roversi, Maria F.
D'Amico, Roberto
Iughetti, Lorenzo
Berardi, Alberto
author_sort Bedetti, Luca
collection PubMed
description Objective: This study aims to evaluate safety and success rates of lumbar puncture (LP) and to identify factors associated with adverse events or failure of LP in infants. Methods: This two-center prospective observational study investigated infants younger than 90 days of age who underwent LP. Need for resuscitation oxygen desaturation (SpO(2) < 90%), bradycardia and intraventricular hemorrhage were considered adverse events. LP failed if cerebrospinal spinal fluid was not collected or had traces of blood. Logistic regression analysis was used to evaluate whether corrected gestational age (GA), body weight at LP, position, and any respiratory support during LP affected SpO(2) desaturation or failure of LP. Results: Among 204 LPs, 134 were performed in full-term and 70 in pre-term born infants. SpO(2) desaturations occurred during 45 (22.4%) LPs. At multivariate analysis, lower GA at LP (p < 0.001), non-invasive respiratory support (p 0.007) and mechanical ventilation (p 0.004) were associated with SpO(2) desaturations. Transient, self-resolving bradycardia occurred in 7 (3.4%) infants. Two infants had intraventricular hemorrhage detected within 72 h of LP. No further adverse events were registered. Failure of LP occurred in 38.2% of cases and was not associated with any of the factors evaluated. Conclusions: LP was safe in most infants. Body weight or GA at LP did not affect LP failure. These data are useful to clinicians, providing information on the safety of the procedure.
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spelling pubmed-82405892021-06-30 Safety and Success of Lumbar Puncture in Young Infants: A Prospective Observational Study Bedetti, Luca Lugli, Licia Marrozzini, Lucia Baraldi, Alessandro Leone, Federica Baroni, Lorenza Lucaccioni, Laura Rossi, Cecilia Roversi, Maria F. D'Amico, Roberto Iughetti, Lorenzo Berardi, Alberto Front Pediatr Pediatrics Objective: This study aims to evaluate safety and success rates of lumbar puncture (LP) and to identify factors associated with adverse events or failure of LP in infants. Methods: This two-center prospective observational study investigated infants younger than 90 days of age who underwent LP. Need for resuscitation oxygen desaturation (SpO(2) < 90%), bradycardia and intraventricular hemorrhage were considered adverse events. LP failed if cerebrospinal spinal fluid was not collected or had traces of blood. Logistic regression analysis was used to evaluate whether corrected gestational age (GA), body weight at LP, position, and any respiratory support during LP affected SpO(2) desaturation or failure of LP. Results: Among 204 LPs, 134 were performed in full-term and 70 in pre-term born infants. SpO(2) desaturations occurred during 45 (22.4%) LPs. At multivariate analysis, lower GA at LP (p < 0.001), non-invasive respiratory support (p 0.007) and mechanical ventilation (p 0.004) were associated with SpO(2) desaturations. Transient, self-resolving bradycardia occurred in 7 (3.4%) infants. Two infants had intraventricular hemorrhage detected within 72 h of LP. No further adverse events were registered. Failure of LP occurred in 38.2% of cases and was not associated with any of the factors evaluated. Conclusions: LP was safe in most infants. Body weight or GA at LP did not affect LP failure. These data are useful to clinicians, providing information on the safety of the procedure. Frontiers Media S.A. 2021-06-14 /pmc/articles/PMC8240589/ /pubmed/34211946 http://dx.doi.org/10.3389/fped.2021.692652 Text en Copyright © 2021 Bedetti, Lugli, Marrozzini, Baraldi, Leone, Baroni, Lucaccioni, Rossi, Roversi, D'Amico, Iughetti and Berardi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Bedetti, Luca
Lugli, Licia
Marrozzini, Lucia
Baraldi, Alessandro
Leone, Federica
Baroni, Lorenza
Lucaccioni, Laura
Rossi, Cecilia
Roversi, Maria F.
D'Amico, Roberto
Iughetti, Lorenzo
Berardi, Alberto
Safety and Success of Lumbar Puncture in Young Infants: A Prospective Observational Study
title Safety and Success of Lumbar Puncture in Young Infants: A Prospective Observational Study
title_full Safety and Success of Lumbar Puncture in Young Infants: A Prospective Observational Study
title_fullStr Safety and Success of Lumbar Puncture in Young Infants: A Prospective Observational Study
title_full_unstemmed Safety and Success of Lumbar Puncture in Young Infants: A Prospective Observational Study
title_short Safety and Success of Lumbar Puncture in Young Infants: A Prospective Observational Study
title_sort safety and success of lumbar puncture in young infants: a prospective observational study
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8240589/
https://www.ncbi.nlm.nih.gov/pubmed/34211946
http://dx.doi.org/10.3389/fped.2021.692652
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