SARS-CoV-2 under an elimination strategy in Hong Kong

Hong Kong utilized an elimination strategy with intermittent use of public health and social measures and increasingly stringent travel regulations to control SARS-CoV-2 transmission. By analyzing >1700 genome sequences representing 17% of confirmed cases from 23-January-2020 to 26-January-2021,...

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Detalles Bibliográficos
Autores principales: Gu, Haogao, Xie, Ruopeng, Adam, Dillon C., Tsui, Joseph L.-H., Chu, Daniel K., Chang, Lydia D.J., Cheuk, Sammi S.Y., Gurung, Shreya, Krishnan, Pavithra, Ng, Daisy Y.M., Liu, Gigi Y.Z., Wan, Carrie K.C., Edwards, Kimberly M., Leung, Kathy S.M., Wu, Joseph T., Tsang, Dominic N.C., Leung, Gabriel M., Cowling, Benjamin J., Peiris, Malik, Lam, Tommy T.Y., Dhanasekaran, Vijaykrishna, Poon, Leo L.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8240692/
https://www.ncbi.nlm.nih.gov/pubmed/34189537
http://dx.doi.org/10.1101/2021.06.19.21259169
Descripción
Sumario:Hong Kong utilized an elimination strategy with intermittent use of public health and social measures and increasingly stringent travel regulations to control SARS-CoV-2 transmission. By analyzing >1700 genome sequences representing 17% of confirmed cases from 23-January-2020 to 26-January-2021, we reveal the effects of fluctuating control measures on the evolution and epidemiology of SARS-CoV-2 lineages in Hong Kong. Despite numerous importations, only three introductions were responsible for 90% of locally-acquired cases, two of which circulated cryptically for weeks while less stringent measures were in place. We found that SARS-CoV-2 within-host diversity was most similar among transmission pairs and epidemiological clusters due to a strong transmission bottleneck through which similar genetic background generates similar within-host diversity.

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