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Acceptability of a Mobile Phone Support Tool (Call for Life Uganda) for Promoting Adherence to Antiretroviral Therapy Among Young Adults in a Randomized Controlled Trial: Exploratory Qualitative Study

BACKGROUND: Adherence to treatment is critical for successful treatment outcomes. Although factors influencing antiretroviral therapy (ART) adherence vary, young adults are less likely to adhere owing to psychosocial issues such as stigma, ART-related side effects, and a lack of access to treatment....

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Autores principales: Twimukye, Adelline, Bwanika Naggirinya, Agnes, Parkes-Ratanshi, Rosalind, Kasirye, Ronnie, Kiragga, Agnes, Castelnuovo, Barbara, Wasswa, Jacob, Nabaggala, Maria Sarah, Katabira, Elly, Lamorde, Mohammed, King, Rachel Lisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JMIR Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8240800/
https://www.ncbi.nlm.nih.gov/pubmed/34121665
http://dx.doi.org/10.2196/17418
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author Twimukye, Adelline
Bwanika Naggirinya, Agnes
Parkes-Ratanshi, Rosalind
Kasirye, Ronnie
Kiragga, Agnes
Castelnuovo, Barbara
Wasswa, Jacob
Nabaggala, Maria Sarah
Katabira, Elly
Lamorde, Mohammed
King, Rachel Lisa
author_facet Twimukye, Adelline
Bwanika Naggirinya, Agnes
Parkes-Ratanshi, Rosalind
Kasirye, Ronnie
Kiragga, Agnes
Castelnuovo, Barbara
Wasswa, Jacob
Nabaggala, Maria Sarah
Katabira, Elly
Lamorde, Mohammed
King, Rachel Lisa
author_sort Twimukye, Adelline
collection PubMed
description BACKGROUND: Adherence to treatment is critical for successful treatment outcomes. Although factors influencing antiretroviral therapy (ART) adherence vary, young adults are less likely to adhere owing to psychosocial issues such as stigma, ART-related side effects, and a lack of access to treatment. The Call for Life Uganda (CFLU) mobile health (mHealth) tool is a mobile phone–based technology that provides text messages or interactive voice response functionalities through a web interface and offers 4 modules of support. OBJECTIVE: This study aims to describe the acceptability and feasibility of a mobile phone support tool to promote adherence to ART among young adults in a randomized controlled trial. METHODS: An exploratory qualitative design with a phenomenological approach at 2 study sites was used. A total of 17 purposively selected young adults with HIV infection who had used the mHealth tool CFLU from 2 clinics were included. In total, 11 in-depth interviews and 1 focus group discussion were conducted to examine the following topics: experience with the CFLU tool (benefits and challenges), components of the tool, the efficiency of the system (level of comfort, ease, or difficulty in using the system), how CFLU resolved adherence challenges, and suggestions to improve CFLU. Participants belonged to 4 categories of interest: young adults on ART for the prevention of mother-to-child transmission, young adults switching to or on the second-line ART, positive partners in an HIV-discordant relationship, and young adults initiating the first-line ART. All young adults had 12 months of daily experience using the tool. Data were analyzed using NVivo version 11 software (QSR International Limited) based on a thematic approach. RESULTS: The CFLU mHealth tool was perceived as an acceptable intervention; young adults reported improvement in medication adherence, strengthened clinician-patient relationships, and increased health knowledge from health tips. Appointment reminders and symptom reporting were singled out as beneficial and helped to address the problems of forgetfulness and stigma-related issues. HIV-related stigma was reported by a few young people. Participants requested extra support for scaling up CFLU to make it more youth friendly. Improving the tool to reduce technical issues, including network outages and a period of software failure, was suggested. They suggested that in addition to digital solutions, other support, including the promotion of peer support meetings and the establishment of a designated space and staff members for youth, was also important. CONCLUSIONS: This mHealth tool was an acceptable and feasible strategy for improving ART adherence and retention among young adults in resource-limited settings. TRIAL REGISTRATION: ClinicalTrials.gov NCT02953080; https://clinicaltrials.gov/ct2/show/NCT02953080
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spelling pubmed-82408002021-07-09 Acceptability of a Mobile Phone Support Tool (Call for Life Uganda) for Promoting Adherence to Antiretroviral Therapy Among Young Adults in a Randomized Controlled Trial: Exploratory Qualitative Study Twimukye, Adelline Bwanika Naggirinya, Agnes Parkes-Ratanshi, Rosalind Kasirye, Ronnie Kiragga, Agnes Castelnuovo, Barbara Wasswa, Jacob Nabaggala, Maria Sarah Katabira, Elly Lamorde, Mohammed King, Rachel Lisa JMIR Mhealth Uhealth Original Paper BACKGROUND: Adherence to treatment is critical for successful treatment outcomes. Although factors influencing antiretroviral therapy (ART) adherence vary, young adults are less likely to adhere owing to psychosocial issues such as stigma, ART-related side effects, and a lack of access to treatment. The Call for Life Uganda (CFLU) mobile health (mHealth) tool is a mobile phone–based technology that provides text messages or interactive voice response functionalities through a web interface and offers 4 modules of support. OBJECTIVE: This study aims to describe the acceptability and feasibility of a mobile phone support tool to promote adherence to ART among young adults in a randomized controlled trial. METHODS: An exploratory qualitative design with a phenomenological approach at 2 study sites was used. A total of 17 purposively selected young adults with HIV infection who had used the mHealth tool CFLU from 2 clinics were included. In total, 11 in-depth interviews and 1 focus group discussion were conducted to examine the following topics: experience with the CFLU tool (benefits and challenges), components of the tool, the efficiency of the system (level of comfort, ease, or difficulty in using the system), how CFLU resolved adherence challenges, and suggestions to improve CFLU. Participants belonged to 4 categories of interest: young adults on ART for the prevention of mother-to-child transmission, young adults switching to or on the second-line ART, positive partners in an HIV-discordant relationship, and young adults initiating the first-line ART. All young adults had 12 months of daily experience using the tool. Data were analyzed using NVivo version 11 software (QSR International Limited) based on a thematic approach. RESULTS: The CFLU mHealth tool was perceived as an acceptable intervention; young adults reported improvement in medication adherence, strengthened clinician-patient relationships, and increased health knowledge from health tips. Appointment reminders and symptom reporting were singled out as beneficial and helped to address the problems of forgetfulness and stigma-related issues. HIV-related stigma was reported by a few young people. Participants requested extra support for scaling up CFLU to make it more youth friendly. Improving the tool to reduce technical issues, including network outages and a period of software failure, was suggested. They suggested that in addition to digital solutions, other support, including the promotion of peer support meetings and the establishment of a designated space and staff members for youth, was also important. CONCLUSIONS: This mHealth tool was an acceptable and feasible strategy for improving ART adherence and retention among young adults in resource-limited settings. TRIAL REGISTRATION: ClinicalTrials.gov NCT02953080; https://clinicaltrials.gov/ct2/show/NCT02953080 JMIR Publications 2021-06-14 /pmc/articles/PMC8240800/ /pubmed/34121665 http://dx.doi.org/10.2196/17418 Text en ©Adelline Twimukye, Agnes Bwanika Naggirinya, Rosalind Parkes-Ratanshi, Ronnie Kasirye, Agnes Kiragga, Barbara Castelnuovo, Jacob Wasswa, Maria Sarah Nabaggala, Elly Katabira, Mohammed Lamorde, Rachel Lisa King. Originally published in JMIR mHealth and uHealth (https://mhealth.jmir.org), 14.06.2021. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR mHealth and uHealth, is properly cited. The complete bibliographic information, a link to the original publication on https://mhealth.jmir.org/, as well as this copyright and license information must be included.
spellingShingle Original Paper
Twimukye, Adelline
Bwanika Naggirinya, Agnes
Parkes-Ratanshi, Rosalind
Kasirye, Ronnie
Kiragga, Agnes
Castelnuovo, Barbara
Wasswa, Jacob
Nabaggala, Maria Sarah
Katabira, Elly
Lamorde, Mohammed
King, Rachel Lisa
Acceptability of a Mobile Phone Support Tool (Call for Life Uganda) for Promoting Adherence to Antiretroviral Therapy Among Young Adults in a Randomized Controlled Trial: Exploratory Qualitative Study
title Acceptability of a Mobile Phone Support Tool (Call for Life Uganda) for Promoting Adherence to Antiretroviral Therapy Among Young Adults in a Randomized Controlled Trial: Exploratory Qualitative Study
title_full Acceptability of a Mobile Phone Support Tool (Call for Life Uganda) for Promoting Adherence to Antiretroviral Therapy Among Young Adults in a Randomized Controlled Trial: Exploratory Qualitative Study
title_fullStr Acceptability of a Mobile Phone Support Tool (Call for Life Uganda) for Promoting Adherence to Antiretroviral Therapy Among Young Adults in a Randomized Controlled Trial: Exploratory Qualitative Study
title_full_unstemmed Acceptability of a Mobile Phone Support Tool (Call for Life Uganda) for Promoting Adherence to Antiretroviral Therapy Among Young Adults in a Randomized Controlled Trial: Exploratory Qualitative Study
title_short Acceptability of a Mobile Phone Support Tool (Call for Life Uganda) for Promoting Adherence to Antiretroviral Therapy Among Young Adults in a Randomized Controlled Trial: Exploratory Qualitative Study
title_sort acceptability of a mobile phone support tool (call for life uganda) for promoting adherence to antiretroviral therapy among young adults in a randomized controlled trial: exploratory qualitative study
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8240800/
https://www.ncbi.nlm.nih.gov/pubmed/34121665
http://dx.doi.org/10.2196/17418
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