Sequence and Structure Characteristics of 22 Deletion Breakpoints in Intron 44 of the DMD Gene Based on Long-Read Sequencing

Purpose: Exon deletions make up to 80% of mutations in the DMD gene, which cause Duchenne and Becker muscular dystrophy. Exon 45-55 regions were reported as deletion hotspots and intron 44 harbored more than 25% of deletion start points. We aimed to investigate the fine structures of breakpoints in...

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Detalles Bibliográficos
Autores principales: Geng, Chang, Tong, Yuanren, Zhang, Siwen, Ling, Chao, Wu, Xin, Wang, Depeng, Dai, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8240811/
https://www.ncbi.nlm.nih.gov/pubmed/34211494
http://dx.doi.org/10.3389/fgene.2021.638220

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8240811/
https://www.ncbi.nlm.nih.gov/pubmed/34211494
http://dx.doi.org/10.3389/fgene.2021.638220

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