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Changes in White Matter of the Cervical Spinal Cord after a Single Season of Collegiate Football

The involvement of the central nervous system (CNS), specifically the white matter tracts in the cervical spinal cord, was examined with diffusion tensor imaging (DTI) following exposure to repetitive head acceleration events (HAEs) after a single season of collegiate football. Fifteen National Coll...

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Detalles Bibliográficos
Autores principales: Johnson, Brian, Walter, Alexa E., Wilkes, James R., Papa, Linda, Slobounov, Semyon M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8240824/
https://www.ncbi.nlm.nih.gov/pubmed/34223548
http://dx.doi.org/10.1089/neur.2020.0035
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author Johnson, Brian
Walter, Alexa E.
Wilkes, James R.
Papa, Linda
Slobounov, Semyon M.
author_facet Johnson, Brian
Walter, Alexa E.
Wilkes, James R.
Papa, Linda
Slobounov, Semyon M.
author_sort Johnson, Brian
collection PubMed
description The involvement of the central nervous system (CNS), specifically the white matter tracts in the cervical spinal cord, was examined with diffusion tensor imaging (DTI) following exposure to repetitive head acceleration events (HAEs) after a single season of collegiate football. Fifteen National Collegiate Athletic Association (NCAA) Division 1 football players underwent DTI of the cervical spinal cord (vertebral level C1–4) at pre-season (before any contact practices began) and post-season (within 1 week of the last regular season game) intervals. Helmet accelerometer data were also collected in parallel throughout the season. From pre-season to post-season, a significant decrease (p < 0.05) of axial diffusivity was seen within the right spino-olivary tract. In addition, a significant decrease (p < 0.05) in global white matter fractional anisotropy (FA) along with increases (p < 0.05) in global white matter mean diffusivity (MD) and radial diffusivity (RD) were found. These changes in FA from pre-season to post-season were significantly moderated by previous concussion history (p < 0.05) and number of HAEs over 80 g (p < 0.05). Despite the absence of sports-related concussion (SRC), we present measurable changes in the white matter integrity of the cervical spinal cord suggesting injury from repetitive HAEs, or SRC, may include the entirety of the CNS, not just the brain.
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spelling pubmed-82408242021-07-02 Changes in White Matter of the Cervical Spinal Cord after a Single Season of Collegiate Football Johnson, Brian Walter, Alexa E. Wilkes, James R. Papa, Linda Slobounov, Semyon M. Neurotrauma Rep Original Article The involvement of the central nervous system (CNS), specifically the white matter tracts in the cervical spinal cord, was examined with diffusion tensor imaging (DTI) following exposure to repetitive head acceleration events (HAEs) after a single season of collegiate football. Fifteen National Collegiate Athletic Association (NCAA) Division 1 football players underwent DTI of the cervical spinal cord (vertebral level C1–4) at pre-season (before any contact practices began) and post-season (within 1 week of the last regular season game) intervals. Helmet accelerometer data were also collected in parallel throughout the season. From pre-season to post-season, a significant decrease (p < 0.05) of axial diffusivity was seen within the right spino-olivary tract. In addition, a significant decrease (p < 0.05) in global white matter fractional anisotropy (FA) along with increases (p < 0.05) in global white matter mean diffusivity (MD) and radial diffusivity (RD) were found. These changes in FA from pre-season to post-season were significantly moderated by previous concussion history (p < 0.05) and number of HAEs over 80 g (p < 0.05). Despite the absence of sports-related concussion (SRC), we present measurable changes in the white matter integrity of the cervical spinal cord suggesting injury from repetitive HAEs, or SRC, may include the entirety of the CNS, not just the brain. Mary Ann Liebert, Inc., publishers 2021-02-17 /pmc/articles/PMC8240824/ /pubmed/34223548 http://dx.doi.org/10.1089/neur.2020.0035 Text en © Brian Johnson et al., 2021; Published by Mary Ann Liebert, Inc. https://creativecommons.org/licenses/by/4.0/This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
spellingShingle Original Article
Johnson, Brian
Walter, Alexa E.
Wilkes, James R.
Papa, Linda
Slobounov, Semyon M.
Changes in White Matter of the Cervical Spinal Cord after a Single Season of Collegiate Football
title Changes in White Matter of the Cervical Spinal Cord after a Single Season of Collegiate Football
title_full Changes in White Matter of the Cervical Spinal Cord after a Single Season of Collegiate Football
title_fullStr Changes in White Matter of the Cervical Spinal Cord after a Single Season of Collegiate Football
title_full_unstemmed Changes in White Matter of the Cervical Spinal Cord after a Single Season of Collegiate Football
title_short Changes in White Matter of the Cervical Spinal Cord after a Single Season of Collegiate Football
title_sort changes in white matter of the cervical spinal cord after a single season of collegiate football
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8240824/
https://www.ncbi.nlm.nih.gov/pubmed/34223548
http://dx.doi.org/10.1089/neur.2020.0035
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