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Effect of Weight Class on Regional Brain Volume, Cognition, and Other Neuropsychiatric Outcomes among Professional Fighters

Traumatic brain injury (TBI) is a common source of functional impairment among athletes, military personnel, and the general population. Professional fighters in both boxing and mixed martial arts (MMA) are at particular risk for repetitive TBI and may provide valuable insight into both the pathophy...

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Autores principales: Bray, Michael J.C., Tsai, Jerry, Bryant, Barry R., Narapareddy, Bharat R., Richey, Lisa N., Krieg, Akshay, Tobolowsky, William, Jahed, Sahar, Shan, Guogen, Bernick, Charles B., Peters, Matthew E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8240832/
https://www.ncbi.nlm.nih.gov/pubmed/34223552
http://dx.doi.org/10.1089/neur.2020.0057
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author Bray, Michael J.C.
Tsai, Jerry
Bryant, Barry R.
Narapareddy, Bharat R.
Richey, Lisa N.
Krieg, Akshay
Tobolowsky, William
Jahed, Sahar
Shan, Guogen
Bernick, Charles B.
Peters, Matthew E.
author_facet Bray, Michael J.C.
Tsai, Jerry
Bryant, Barry R.
Narapareddy, Bharat R.
Richey, Lisa N.
Krieg, Akshay
Tobolowsky, William
Jahed, Sahar
Shan, Guogen
Bernick, Charles B.
Peters, Matthew E.
author_sort Bray, Michael J.C.
collection PubMed
description Traumatic brain injury (TBI) is a common source of functional impairment among athletes, military personnel, and the general population. Professional fighters in both boxing and mixed martial arts (MMA) are at particular risk for repetitive TBI and may provide valuable insight into both the pathophysiology of TBI and its consequences. Currently, effects of fighter weight class on brain volumetrics (regional and total) and functional outcomes are unknown. Fifty-three boxers and 103 MMA fighters participating in the Professional Fighters Brain Health Study (PRBHS) underwent volumetric magnetic resonance imaging (MRI) and neuropsychological testing. Fighters were divided into lightweight (≤139.9 lb), middleweight (140.0–178.5 lb), and heavyweight (>178.5 lb). Compared with lightweight fighters, heavyweights displayed greater yearly reductions in regional brain volume (boxers: bilateral thalami; MMA: left thalamus, right putamen) and functional performance (boxers: processing speed, simple and choice reaction; MMA: Trails A and B tests). Lightweights suffered greater reductions in regional brain volume on a per-fight basis (boxers: left thalamus; MMA: right putamen). Heavyweight fighters bore greater yearly burden of regional brain volume and functional decrements, possibly related to differing fight dynamics and force of strikes in this division. Lightweights demonstrated greater volumetric decrements on a per-fight basis. Although more research is needed, greater per-fight decrements in lightweights may be related to practices of weight-cutting, which may increase vulnerability to neurodegeneration post-TBI. Observed decrements associated with weight class may result in progressive impairments in fighter performance, suggesting interventions mitigating the burden of TBI in professional fighters may both improve brain health and increase professional longevity.
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spelling pubmed-82408322021-07-02 Effect of Weight Class on Regional Brain Volume, Cognition, and Other Neuropsychiatric Outcomes among Professional Fighters Bray, Michael J.C. Tsai, Jerry Bryant, Barry R. Narapareddy, Bharat R. Richey, Lisa N. Krieg, Akshay Tobolowsky, William Jahed, Sahar Shan, Guogen Bernick, Charles B. Peters, Matthew E. Neurotrauma Rep Original Article Traumatic brain injury (TBI) is a common source of functional impairment among athletes, military personnel, and the general population. Professional fighters in both boxing and mixed martial arts (MMA) are at particular risk for repetitive TBI and may provide valuable insight into both the pathophysiology of TBI and its consequences. Currently, effects of fighter weight class on brain volumetrics (regional and total) and functional outcomes are unknown. Fifty-three boxers and 103 MMA fighters participating in the Professional Fighters Brain Health Study (PRBHS) underwent volumetric magnetic resonance imaging (MRI) and neuropsychological testing. Fighters were divided into lightweight (≤139.9 lb), middleweight (140.0–178.5 lb), and heavyweight (>178.5 lb). Compared with lightweight fighters, heavyweights displayed greater yearly reductions in regional brain volume (boxers: bilateral thalami; MMA: left thalamus, right putamen) and functional performance (boxers: processing speed, simple and choice reaction; MMA: Trails A and B tests). Lightweights suffered greater reductions in regional brain volume on a per-fight basis (boxers: left thalamus; MMA: right putamen). Heavyweight fighters bore greater yearly burden of regional brain volume and functional decrements, possibly related to differing fight dynamics and force of strikes in this division. Lightweights demonstrated greater volumetric decrements on a per-fight basis. Although more research is needed, greater per-fight decrements in lightweights may be related to practices of weight-cutting, which may increase vulnerability to neurodegeneration post-TBI. Observed decrements associated with weight class may result in progressive impairments in fighter performance, suggesting interventions mitigating the burden of TBI in professional fighters may both improve brain health and increase professional longevity. Mary Ann Liebert, Inc., publishers 2021-03-18 /pmc/articles/PMC8240832/ /pubmed/34223552 http://dx.doi.org/10.1089/neur.2020.0057 Text en © Michael J.C. Bray et al., 2021; Published by Mary Ann Liebert, Inc. https://creativecommons.org/licenses/by/4.0/This Open Access article is distributed under the terms of the Creative Commons License (CC-BY) (http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
spellingShingle Original Article
Bray, Michael J.C.
Tsai, Jerry
Bryant, Barry R.
Narapareddy, Bharat R.
Richey, Lisa N.
Krieg, Akshay
Tobolowsky, William
Jahed, Sahar
Shan, Guogen
Bernick, Charles B.
Peters, Matthew E.
Effect of Weight Class on Regional Brain Volume, Cognition, and Other Neuropsychiatric Outcomes among Professional Fighters
title Effect of Weight Class on Regional Brain Volume, Cognition, and Other Neuropsychiatric Outcomes among Professional Fighters
title_full Effect of Weight Class on Regional Brain Volume, Cognition, and Other Neuropsychiatric Outcomes among Professional Fighters
title_fullStr Effect of Weight Class on Regional Brain Volume, Cognition, and Other Neuropsychiatric Outcomes among Professional Fighters
title_full_unstemmed Effect of Weight Class on Regional Brain Volume, Cognition, and Other Neuropsychiatric Outcomes among Professional Fighters
title_short Effect of Weight Class on Regional Brain Volume, Cognition, and Other Neuropsychiatric Outcomes among Professional Fighters
title_sort effect of weight class on regional brain volume, cognition, and other neuropsychiatric outcomes among professional fighters
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8240832/
https://www.ncbi.nlm.nih.gov/pubmed/34223552
http://dx.doi.org/10.1089/neur.2020.0057
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