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Development of DNA tetrahedron-based drug delivery system

Nanocarriers of drugs have attracted significant attention to tackle the problems of drug resistance or nucleic acid drug delivery, which can optimize pharmaceutical parameters and enhance the cellular uptake efficiency. Nowadays, DNA nanostructure presents an opportunity in the field of nanomateria...

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Detalles Bibliográficos
Autores principales: Hu, Yue, Chen, Zhou, Zhang, He, Li, Mingkai, Hou, Zheng, Luo, Xiaoxing, Xue, Xiaoyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241089/
https://www.ncbi.nlm.nih.gov/pubmed/28891335
http://dx.doi.org/10.1080/10717544.2017.1373166
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author Hu, Yue
Chen, Zhou
Zhang, He
Li, Mingkai
Hou, Zheng
Luo, Xiaoxing
Xue, Xiaoyan
author_facet Hu, Yue
Chen, Zhou
Zhang, He
Li, Mingkai
Hou, Zheng
Luo, Xiaoxing
Xue, Xiaoyan
author_sort Hu, Yue
collection PubMed
description Nanocarriers of drugs have attracted significant attention to tackle the problems of drug resistance or nucleic acid drug delivery, which can optimize pharmaceutical parameters and enhance the cellular uptake efficiency. Nowadays, DNA nanostructure presents an opportunity in the field of nanomaterial due to its precise control in shape and size, excellent biocompatibility, as well as multiple sites for targeting decoration. DNA tetrahedron, which is stable and easily synthesized, is used for various applications, including nuclear magnetic resonance imaging, molecular diagnosis, targeting drug delivery, and so on. In this review, we will discuss the applications of DNA tetrahedron about drug delivery, intracellular routes and its fates. Also challenges and possible solutions for developing DNA tetrahedron-based drug delivery system are detailed.
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spelling pubmed-82410892021-07-08 Development of DNA tetrahedron-based drug delivery system Hu, Yue Chen, Zhou Zhang, He Li, Mingkai Hou, Zheng Luo, Xiaoxing Xue, Xiaoyan Drug Deliv Review Article Nanocarriers of drugs have attracted significant attention to tackle the problems of drug resistance or nucleic acid drug delivery, which can optimize pharmaceutical parameters and enhance the cellular uptake efficiency. Nowadays, DNA nanostructure presents an opportunity in the field of nanomaterial due to its precise control in shape and size, excellent biocompatibility, as well as multiple sites for targeting decoration. DNA tetrahedron, which is stable and easily synthesized, is used for various applications, including nuclear magnetic resonance imaging, molecular diagnosis, targeting drug delivery, and so on. In this review, we will discuss the applications of DNA tetrahedron about drug delivery, intracellular routes and its fates. Also challenges and possible solutions for developing DNA tetrahedron-based drug delivery system are detailed. Taylor & Francis 2017-09-11 /pmc/articles/PMC8241089/ /pubmed/28891335 http://dx.doi.org/10.1080/10717544.2017.1373166 Text en © 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Hu, Yue
Chen, Zhou
Zhang, He
Li, Mingkai
Hou, Zheng
Luo, Xiaoxing
Xue, Xiaoyan
Development of DNA tetrahedron-based drug delivery system
title Development of DNA tetrahedron-based drug delivery system
title_full Development of DNA tetrahedron-based drug delivery system
title_fullStr Development of DNA tetrahedron-based drug delivery system
title_full_unstemmed Development of DNA tetrahedron-based drug delivery system
title_short Development of DNA tetrahedron-based drug delivery system
title_sort development of dna tetrahedron-based drug delivery system
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241089/
https://www.ncbi.nlm.nih.gov/pubmed/28891335
http://dx.doi.org/10.1080/10717544.2017.1373166
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