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Agomelatine-based in situ gels for brain targeting via the nasal route: statistical optimization, in vitro, and in vivo evaluation

Agomelatine (AGM) is an antidepressant drug with a low absolute bioavailability due to the hepatic first pass metabolism. AGM-loaded solid lipid nanoparticles were formulated in the form of an in situ gel to prolong the intranasal retention time and subsequently to increase the absorbed amount of AG...

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Detalles Bibliográficos
Autores principales:	Fatouh, Ahmed M., Elshafeey, Ahmed H., Abdelbary, Ahmed
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241098/ https://www.ncbi.nlm.nih.gov/pubmed/28745530 http://dx.doi.org/10.1080/10717544.2017.1357148

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