VEGF-mediated tight junctions pathological fenestration enhances doxorubicin-loaded glycolipid-like nanoparticles traversing BBB for glioblastoma-targeting therapy

The existence of blood–brain barrier (BBB) greatly hindered the penetration and accumulation of chemotherapeutics into glioblastoma (GBM), accompany with poor therapeutic effects. The growth of GBM supervene the impairment of tight junctions (TJs); however, the pathogenesis of BBB breakdown in GBM i...

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Detalles Bibliográficos
Autores principales: Wen, Lijuan, Tan, Yanan, Dai, Suhuan, Zhu, Yun, Meng, Tingting, Yang, Xiqin, Liu, Yupeng, Liu, Xuan, Yuan, Hong, Hu, Fuqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241127/
https://www.ncbi.nlm.nih.gov/pubmed/29182025
http://dx.doi.org/10.1080/10717544.2017.1386731

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