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Transpathology: molecular imaging-based pathology

Pathology is the medical specialty concerned with the study of the disease nature and causes, playing a key role in bridging basic researches and clinical medicine. In the course of development, pathology has significantly expanded our understanding of disease, and exerted enormous impact on the man...

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Autores principales: Tian, Mei, He, Xuexin, Jin, Chentao, He, Xiao, Wu, Shuang, Zhou, Rui, Zhang, Xiaohui, Zhang, Kai, Gu, Weizhong, Wang, Jing, Zhang, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241651/
https://www.ncbi.nlm.nih.gov/pubmed/33585964
http://dx.doi.org/10.1007/s00259-021-05234-1
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author Tian, Mei
He, Xuexin
Jin, Chentao
He, Xiao
Wu, Shuang
Zhou, Rui
Zhang, Xiaohui
Zhang, Kai
Gu, Weizhong
Wang, Jing
Zhang, Hong
author_facet Tian, Mei
He, Xuexin
Jin, Chentao
He, Xiao
Wu, Shuang
Zhou, Rui
Zhang, Xiaohui
Zhang, Kai
Gu, Weizhong
Wang, Jing
Zhang, Hong
author_sort Tian, Mei
collection PubMed
description Pathology is the medical specialty concerned with the study of the disease nature and causes, playing a key role in bridging basic researches and clinical medicine. In the course of development, pathology has significantly expanded our understanding of disease, and exerted enormous impact on the management of patients. However, challenges facing pathology, the inherent invasiveness of pathological practice and the persistent concerns on the sample representativeness, constitute its limitations. Molecular imaging is a noninvasive technique to visualize, characterize, and measure biological processes at the molecular level in living subjects. With the continuous development of equipment and probes, molecular imaging has enabled an increasingly precise evaluation of pathophysiological changes. A new pathophysiology visualization system based on molecular imaging is forming and shows the great potential to reform the pathological practice. Several improvements in “trans-,” including trans-scale, transparency, and translation, would be driven by this new kind of pathological practice. Pathological changes could be evaluated in a trans-scale imaging mode; tissues could be transparentized to better present the underlying pathophysiological information; and the translational processes of basic research to the clinical practice would be better facilitated. Thus, transpathology would greatly facilitate in deciphering the pathophysiological events in a multiscale perspective, and supporting the precision medicine in the future.
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spelling pubmed-82416512021-07-13 Transpathology: molecular imaging-based pathology Tian, Mei He, Xuexin Jin, Chentao He, Xiao Wu, Shuang Zhou, Rui Zhang, Xiaohui Zhang, Kai Gu, Weizhong Wang, Jing Zhang, Hong Eur J Nucl Med Mol Imaging Review Article Pathology is the medical specialty concerned with the study of the disease nature and causes, playing a key role in bridging basic researches and clinical medicine. In the course of development, pathology has significantly expanded our understanding of disease, and exerted enormous impact on the management of patients. However, challenges facing pathology, the inherent invasiveness of pathological practice and the persistent concerns on the sample representativeness, constitute its limitations. Molecular imaging is a noninvasive technique to visualize, characterize, and measure biological processes at the molecular level in living subjects. With the continuous development of equipment and probes, molecular imaging has enabled an increasingly precise evaluation of pathophysiological changes. A new pathophysiology visualization system based on molecular imaging is forming and shows the great potential to reform the pathological practice. Several improvements in “trans-,” including trans-scale, transparency, and translation, would be driven by this new kind of pathological practice. Pathological changes could be evaluated in a trans-scale imaging mode; tissues could be transparentized to better present the underlying pathophysiological information; and the translational processes of basic research to the clinical practice would be better facilitated. Thus, transpathology would greatly facilitate in deciphering the pathophysiological events in a multiscale perspective, and supporting the precision medicine in the future. Springer Berlin Heidelberg 2021-02-13 2021 /pmc/articles/PMC8241651/ /pubmed/33585964 http://dx.doi.org/10.1007/s00259-021-05234-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Tian, Mei
He, Xuexin
Jin, Chentao
He, Xiao
Wu, Shuang
Zhou, Rui
Zhang, Xiaohui
Zhang, Kai
Gu, Weizhong
Wang, Jing
Zhang, Hong
Transpathology: molecular imaging-based pathology
title Transpathology: molecular imaging-based pathology
title_full Transpathology: molecular imaging-based pathology
title_fullStr Transpathology: molecular imaging-based pathology
title_full_unstemmed Transpathology: molecular imaging-based pathology
title_short Transpathology: molecular imaging-based pathology
title_sort transpathology: molecular imaging-based pathology
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241651/
https://www.ncbi.nlm.nih.gov/pubmed/33585964
http://dx.doi.org/10.1007/s00259-021-05234-1
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